Kidney research, 2026-09-03
A pig kidney helped one person wait for a human donor, and new research looks at herbal capsules, games for kids, and diabetes trends
Today’s top story is a first-in-human case where a pig kidney supported a patient until a human donor kidney became available. Researchers also pooled data on a Chinese herbal medicine for glomerular disease, tested a health education game for children with kidney disease, and analyzed long-term trends in diabetic kidney disease across three countries. None of these findings change current treatment guidelines, but they add to what’s being studied for future care.
Joint Impact of Aldosterone and Low-Density Lipoprotein Cholesterol on Cardiovascular Risk in CKD
People with advanced kidney disease die of heart disease more than anything else. This piece looks at two things that drive that risk together: LDL cholesterol, the kind that...
Impact of Personalized Anemia Management on Quality of Life and Serum Albumin Levels in Maintenance Hemodialysis Patients.
Researchers looked back at records of people on long-term dialysis who were treated for anemia, meaning a low red blood cell count. Those whose anemia care was tailored to them...
Impact of Dapagliflozin on Kidney Function Decline in Chronic Kidney Disease Patients: A Systematic Review.
Researchers searched six databases and pulled together 15 randomized trials of dapagliflozin in people with chronic kidney disease. Dapagliflozin started as a diabetes drug and is...
Ketoacidosis with SGLT2 inhibitors in routine clinical practice of type 2 diabetes: Scandinavian cohort and nested case-control study.
SGLT2 inhibitors, the drug family that includes dapagliflozin and empagliflozin, can cause ketoacidosis, a dangerous buildup of acid in the blood. This study used national health...
Effects of semaglutide and empagliflozin on markers of endothelial function in persons with type 2 diabetes: A post hoc analysis of a randomized clinical trial.
This is a second look at data from a randomized trial comparing semaglutide and empagliflozin in people with type 2 diabetes. It asks whether either drug improves the health of the...
New Evidence in Heart Failure: 2026 Update.
A yearly round-up of what is new in heart failure research, covering who gets it, how it progresses, and how outcomes are changing. It touches kidney disease only as one of several...
Clinical impact of Moraxella catarrhalis detection in respiratory illnesses: a comparative study of pediatric and adult populations in Taiwan.
A hospital in Taiwan reviewed records of children and adults who tested positive for Moraxella catarrhalis, a common respiratory bacterium, to see how sick they got. This is a lung...
Data-driven discovery of candidate predictors of future rheumatoid arthritis diagnosis in the UK biobank.
Researchers ran machine learning over 445,515 UK Biobank participants, including 4,510 who later developed rheumatoid arthritis, to find early signs of that disease. Follow-up ran...
RANDOMIZED CONTROLLED STUDY OF NEMOLIZUMAB IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND ASSOCIATED PRURITUS: NIKAIA-1.
A drug called nemolizumab was tested against the severe itching that comes with kidney failure. It was a randomized trial: 258 people on dialysis got either the drug or a dummy...
An Invisible Bladder Stone Causing Silent Obstructive Kidney Failure
A 60 year old man felt completely fine, but a routine work physical found severe kidney failure and new diabetes. His creatinine, a waste product that rises when kidneys fail, was...
Skeletal oxalosis in a child on maintenance hemodialysis
A 13 year old girl on dialysis three times a week for 2 years developed worsening bone pain and could barely move. Doctors found oxalate crystals piling up in her bones, from a...
Use of Pegmolesatide in Renal Anemia: Efficacy and Safety of Switching to Pegmolesatide in Non-dialysis CKD Patients Treated With rhuEPO or HIF-PHI
A trial is starting on switching anemia treatment in kidney disease. About 160 people not yet on dialysis, already taking EPO shots or a HIF-PHI pill, will be randomly moved to a...
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
A phase 3 trial is planned for elecoglipron, a new diabetes drug, in adults with type 2 diabetes and reduced kidney function. Everyone in it will already be on dapagliflozin, an...
Incretin-based therapies in diabetic kidney disease: toward integrated cardio-kidney-metabolic disease modification.
This is a review article, not a new study. It gathers what is known about GLP-1 drugs, the semaglutide family, for people with diabetes and kidney disease. Its argument is that...
Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications.
This review argues the liver belongs alongside the heart, kidneys and metabolism as one linked condition rather than four separate problems. Large group studies show that people...
PRO/CON debate: nonsteroidal versus steroidal mineralocorticoid receptor antagonists in chronic kidney disease: progress, pragmatism, and remaining uncertainties.
Two sides argue over which kind of hormone-blocking drug is better for chronic kidney disease. The older drugs, spironolactone and eplerenone, cut protein leaking into the urine...
Cross-System Meta-Analysis of Machine Learning Predictors Identifies Value-Specific Risk Drivers and Interactions Underlying Acute Kidney Injury
Researchers pooled machine learning models trained on the medical records of 785,497 adults across several health systems to find what drives sudden kidney injury. Rather than just...
Kidney Health Guidance on Cardiovascular-Kidney-Metabolic (CKM) Syndrome
Kidney specialists published guidance on cardiovascular-kidney-metabolic syndrome, the overlap of heart disease, kidney disease and metabolic problems like diabetes and obesity. It...
Preeclampsia-associated nephropathy; current insights into renal histopathology and molecular mechanisms
This is a review of how preeclampsia damages the kidneys. Preeclampsia is a serious blood pressure problem in pregnancy. The article gathers what is known about the changes seen in...
The association between integrin subunit alpha V and vascular endothelial growth factor A polymorphisms and peritoneal dialysis adequacy
This study tested whether two genes, ITGAV and VEGF-A, are tied to how well peritoneal dialysis works. Peritoneal dialysis uses the lining of the belly to filter the blood, usually...
Corticosteroids in childhood IgA vasculitis: can early therapy mask kidney involvement?
This is a commentary asking whether giving steroids early in childhood IgA vasculitis can hide kidney damage. IgA vasculitis inflames small blood vessels and can injure the...
Digenic disease causing variants in a patient with severe nephrocalcinosis
Doctors report one patient with severe nephrocalcinosis, which means calcium deposits building up inside the kidney. Testing found harmful changes in two different genes at once,...
Integrated Serum Lipidomics, Renal Transcriptomics, and Mendelian Randomization Reveal Glycerophospholipid Dysregulation in Calcium Oxalate Kidney Stones
Researchers compared fat molecules in the blood and gene activity in kidney tissue in people with calcium oxalate kidney stones. They found a pattern of disturbed fats, and used a...
The role of classical protein tyrosine phosphatases in diabetic kidney disease and therapeutic implications
This is a review of a family of enzymes called protein tyrosine phosphatases, which act like off switches inside cells, and what they do in kidney disease caused by diabetes. The...
Heterozygous COL4A3/COL4A4 variants: diagnostic trends and clinical kidney outcomes
This study followed people who carry a single altered copy of the COL4A3 or COL4A4 genes, which help build the kidney's filter. Carrying one copy was long thought to be harmless,...
Two variants in SLC34A3 in a patient with X-linked hypophosphatemia: a diagnostic and therapeutic dilemma
This is a report on one patient who had gene changes linked to two different phosphate-wasting conditions at once. Phosphate is a mineral the kidneys either keep or flush out, and...
Increased risk of incident and recurrent urinary tract infection in autosomal dominant polycystic kidney disease: a contemporary propensity score-matched cohort study
People with polycystic kidney disease, an inherited condition where fluid-filled sacs grow in the kidneys, got urinary tract infections more often than similar people without it....
Prognostic Markers in CKD Patients Stratified by Co-morbid Conditions and on Dialysis Therapy
Researchers looked at blood and clinical markers that signal how people with chronic kidney disease are likely to fare, sorted by their other health conditions and by whether they...
A Case of Severe Preeclampsia in the Last Trimester of Pregnancy Complicated by Acute Kidney Injury: A Case Report
This describes one woman in her last three months of pregnancy who had severe preeclampsia, a dangerous rise in blood pressure, and whose kidneys then failed suddenly. It records...
Plasma FGF23 and cardiovascular mortality in relation to kidney function among adults with established cardiovascular disease
In adults who already had heart disease, higher blood levels of a hormone called FGF23 went along with a greater chance of dying from heart problems. FGF23 rises as the kidneys...
Identifying key prognostic indicators for extended hemodialysis survival: A comprehensive analysis of clinical, laboratory, and demographic factors
This study looked back at people on long-term dialysis to work out which things predict who lives longer. It weighed blood test results, other health problems, and basics like age...
Preoperative SGLT2 Inhibitor Use and Outcomes After Major Cardiac Procedures: A Propensity Score-Matched Analysis of the TriNetX Network
SGLT2 inhibitors are diabetes drugs that also slow kidney decline. This study used a large hospital records network to compare people who were taking one before major heart surgery...
Clinical application of sugammadex in renal impairment: pharmacokinetics and pharmacodynamics
Sugammadex is a drug given after surgery to reverse the medicines that keep muscles still. The kidneys clear it from the body, so weak kidneys change how long it lingers. This...
Granular Swollen Epithelial Cells in Native Kidney Biopsies: Prevalence, Clinicopathological Associations and Kidney Outcomes
Doctors examined kidney biopsy samples, small tissue pieces taken from the kidney, and counted how often one kind of damaged cell showed up. They then checked whether people who...
Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells
Researchers studied a protein called Cullin 3 in proximal tubule cells, the kidney cells that pull water and salts back out of urine. They report that it helps set how those cells...
Cell-state- and compartment-dependent PI3K/Akt redox signaling in chronic kidney disease: mechanisms and translational implications
This is a review article, not a new study, so it reports no results of its own. It gathers what is known about a cell signaling pathway called PI3K/Akt and how it responds to...
Extracellular cold-inducible RNA-binding protein in renal ischemia–reperfusion injury and its progression to chronic kidney disease
This paper reviews what is known about a protein called eCIRP, which cells release when blood flow to the kidney is cut off and then restored. That kind of injury can later turn...
Association of cumulative cholesterol-HDL-glucose index with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study
This nationwide study followed adults with early stage heart, kidney and metabolic problems, called stages 0 to 3. It tracked a combined score built from cholesterol, good...
Associations of hs-CRP and interleukin-6 with diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study from Uzbekistan
Researchers in Uzbekistan measured two markers of inflammation in the blood, hs-CRP and interleukin 6, in people with type 2 diabetes. They compared the levels in people who had...
Estimation of risk of nephrogenic systemic fibrosis inpatients of stage 3-5 chronic kidney disease undergoing magnetic resonance imaging with injectable gadobutrol.
This study looked at people with stage 3 to 5 kidney disease who had an MRI scan using gadobutrol, one of the newer gadolinium dyes. It checked how many later developed nephrogenic...
Renal and Systemic Complications in Autosomal Dominant Hypocalcaemia Type 1: A Case Series from North East England
Doctors in North East England described a group of patients with a rare inherited condition that keeps blood calcium too low (autosomal dominant hypocalcaemia type 1). They report...
Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy
This is a review article about how scarring builds up in organs, including the kidney. It argues that physical stress on cells feeds back and drives more scarring, and it proposes...
Development and external validation of a contrastive learning foundation model for ECG-based prediction of cardiovascular diseases and outcomes
Researchers built an artificial intelligence model that reads heart tracings (ECGs) to predict heart disease, then tested it on patients from a separate hospital system. This is a...
High Cardio-Ankle Vascular Index and Plasma Homocysteine Concentration Predict All-Cause Mortality During the First 3 Years of Hemodialysis in End-Stage Chronic Kidney Disease Patients
In people starting dialysis for end-stage kidney disease, two markers predicted who died within the first three years. One is a score for how stiff the arteries are (cardio-ankle...
Impact of chronic kidney disease on long-term outcomes after left main percutaneous coronary intervention: a propensity score-matched analysis with up to 10 years of follow-up
This study followed patients for up to 10 years after a stent procedure on the left main heart artery, comparing those with chronic kidney disease against similar patients without...
Acute Kidney Injury in Patients with Type 2 Diabetes Mellitus: Epidemiology, Risk Factors, and Outcomes in a Tertiary Care Public Sector Hospital in South India
This study looked back at people with type 2 diabetes at one large public hospital in South India who developed sudden kidney injury, a fast drop in how well the kidneys filter. It...
Antiproteinuric effect of dapagliflozin attenuates tubule-interstitial injury development in subclinical acute kidney injury animal model
Animals with early, silent kidney injury were given dapagliflozin, a diabetes drug that makes the kidneys pass extra sugar into the urine. The drug cut the amount of protein...
Renoprotective effects of the erucic acid in experimental diabetic nephropathy: antioxidant, anti-inflammatory, and in silico insights
Erucic acid, a fat found in rapeseed and mustard oils, was tested in animals with kidney damage caused by diabetes. It reduced markers of oxidative stress and inflammation, the two...
Person‐Reported and Continuous Glucose Monitoring ( CGM ) Recorded Hypoglycaemia in People With Insulin‐Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo‐ METRICS Study
Researchers re-analyzed the Hypo-METRICS study, focusing on people with type 2 diabetes who take insulin and also have mild to moderate kidney disease. They compared low blood...
Glycemic assessment when hemoglobin A1c is unreliable: a clinical-laboratory framework for kidney disease, anemia, and hemoglobinopathies
The A1c blood test is meant to show average blood sugar over roughly three months, but it can read wrong in people with kidney disease, low red blood cell counts, or inherited...
Post-translational protein S-palmitoylation in renal tubular injury: mechanisms and therapeutic implications
This is a review of S-palmitoylation, a fatty tag that cells stick onto proteins to control where those proteins sit and what they do. It pulls together lab and animal findings...
Cinacalcet
This is the FDA prescribing label for cinacalcet, a pill for adults on dialysis whose parathyroid glands make too much hormone, which pulls calcium out of the bones. The label...
Rapidly progressive steroid-resistant focal segmental glomerulosclerosis associated with an INF2 exon 6 variant.
A boy had protein in his urine at age 12 and was diagnosed at 14 with FSGS, a scarring of the kidney's filters. Steroids, other immune drugs, and plasma exchange all failed, and...
BRD2-Mediated TGR5 Destabilization Impairs Fatty Acid Oxidation and Drives Tubular Ferroptosis in Diabetic Kidney Injury.
In diabetic mice, a protein called BRD2 built up over time in the kidney tubules, the tiny tubes that reclaim fluid and salt. The extra BRD2 broke down TGR5, a receptor that helps...
Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics and the Pharmacokinetics of Balcinrenone When Dosed with a P-gp Inhibitor.
Balcinrenone is a new drug that blocks the same hormone receptor as older drugs like spironolactone, but is designed to be gentler. It is being developed as one pill combined with...
Postmarketing Safety Signals and Medication-Use Risks of GLP-1-Based Therapies in Diabetes and Obesity: A Multi-Source Pharmacovigilance and Regulatory Evidence-Mapping Study.
Researchers combed through five years of side effect reports sent to the FDA, from early 2021 to early 2026, about GLP-1 drugs such as semaglutide and the twin acting drug...
Sodium-Glucose Cotransporter 2 Inhibition in Diabetic Macular Oedema: Emerging Evidence for Stage-Dependent Systemic-Retinal Responsiveness.
SGLT2 inhibitors are a main drug class for slowing kidney decline, and this review asked what they do to diabetic macular oedema, swelling at the back of the eye that blurs vision....
Finerenone Added to Renin-Angiotensin System- and Sodium-Glucose Cotransporter 2 Inhibition in Patients with Alport Syndrome: A Two-Center Case Series.
Alport syndrome is an inherited kidney disease that often leads to kidney failure. Some people keep losing kidney function even on both standard drug types: blood pressure drugs...
Effects and Safety of Henagliflozin on Cardiac Structure in Dialysis Patients with Heart Failure with Preserved Ejection Fraction.
People on dialysis who also have heart failure with a normal pumping strength have almost no proven drug options. This trial randomly assigned dialysis patients with that condition...
Durvalumab-associated nephrotic syndrome and organizing pneumonia: a case report.
Doctors describe one patient, a 68-year-old man with advanced lung cancer, who started leaking large amounts of protein in his urine while taking the cancer drug durvalumab. A...
ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic Syndrome.
The American Society of Nephrology published advice on treating heart disease, diabetes and kidney disease as one linked problem instead of three separate ones. It says people with...
End-Stage Renal Disease as a Predictor of Ray Amputation and Other Postoperative Sequelae in Finger Amputation
This study looked at people having a finger amputated and asked whether kidney failure needing dialysis predicted a worse result. It reports that end stage kidney disease went...
Age-dependent sex differences in acute kidney injury among patients with chronic kidney disease
This study looked at sudden kidney injury, a fast drop in kidney function, in people who already have chronic kidney disease. It asked whether the risk differs between men and...
SPECTRUM OF KIDNEY DISEASE IN DIABETIC POPULATION- A 3 YEAR STUDY
This is a 3 year look at the kidney problems found in people with diabetes at one hospital. It describes which types of kidney disease showed up and how often. It is observational,...
Efficacy and safety of telitacicept for rituximab-refractory membranous nephropathy
Telitacicept is a drug being tested for membranous nephropathy, a disease where the kidney's filters leak protein into the urine. This report covers people whose disease did not...
Continuous glucose monitoring–guided optimization of peritoneal dialysis prescription in glycogen storage disease type 1a: a case report
This is a report on one person with glycogen storage disease type 1a, a rare inherited problem with handling sugar, who was also on peritoneal dialysis. Doctors used a continuous...
Uremic Serum Alters Gene Expression Profiles and Signaling Pathway Activity in Porcine Arterial Smooth Muscle Cells
When kidneys fail, waste builds up in the blood, a state called uremia. Researchers bathed pig artery muscle cells in blood serum from that state and watched which genes switched...
SGLT2 inhibitors in chronic kidney disease: cardiorenal outcomes, safety, and implementation in primary care
This is a review article about SGLT2 inhibitors, a class of pills first made for diabetes that also protect the kidneys and heart. It pulls together what earlier trials found and...
Gitelman Syndrome: Pathophysiology, Clinical Heterogeneity, and Contemporary Management Strategies in a Prototypical Renal Tubulopathy
This is a review of Gitelman syndrome, an inherited condition where the kidney tubes lose too much salt, potassium and magnesium in the urine. It goes over what causes it, why it...
Relationship between antihypertensive drug classes and ambulatory blood pressure profile in patients with chronic kidney disease
People with chronic kidney disease wore a blood pressure cuff that took readings all day and night, including during sleep. Researchers compared the readings across people taking...
ETIOLOGY-SPECIFIC TRACE ELEMENT IMBALANCE AND ANEMIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE
This report looked at levels of trace elements, such as iron and zinc, in people with chronic kidney disease, and how those levels lined up with anemia, meaning a low red blood...
Trends in diagnosis of amyloid kidney disease in people who inject drugs (PWID)
This study tracked how often doctors diagnosed amyloid kidney disease in people who inject drugs. In that disease an abnormal protein builds up in the kidney's filters and slowly...
Association of 14-day continuous glucose monitoring-derived postprandial hyperglycemic area with 6-month change in urinary albumin-to-creatinine ratio in patients with newly diagnosed type 2 diabetes mellitus.
Adults newly diagnosed with type 2 diabetes wore a blood sugar sensor for 14 days, and doctors measured how high their sugar climbed after meals. Six months later they checked...
Serum Uric Acid in Chronic Kidney Disease as a Marker of Risk or a Modifiable Driver of Progression: A Systematic Review.
This review pulled together studies on uric acid, a waste product healthy kidneys clear, and asked whether high levels actually speed up kidney disease. The problem it describes is...
ECH1-Deficiency-Mediated Polyunsaturated Fatty Acid Accumulation Promotes Vascular Smooth Muscle Cell Ferroptosis and Chronic-Kidney-Disease-Associated Plaque Vulnerability.
In lab tissue and animals, losing a protein called ECH1 let certain fats build up inside the muscle cells that line artery walls. Those cells then died in a specific way, and the...
Evaluation of carotid intima-media thickness and ultrafast pulse wave velocity for cardiovascular events and all-cause mortality in hemodialysis patients: impact of diabetes.
Researchers followed 115 people on regular dialysis for 39 months, a little over three years. They used ultrasound to measure how stiff the arteries were and how thick the neck...
Protective association of the <i>ELMO1</i> rs741301 variant against diabetes mellitus and diabetic nephropathy: a systematic meta-analysis of case-control studies.
This pooled analysis combined earlier studies that compared people who did and did not have diabetes and kidney damage caused by diabetes. It focused on one common gene difference,...
The Ferroptosis-Immunity Axis in Diabetic Kidney Disease: Emerging Therapeutic Targets.
This is a review paper, not a new study. It argues that a type of cell death driven by iron, called ferroptosis, works with the immune system to damage the kidneys in people with...
Type 2 diabetes and chronic kidney disease combinations in heart failure across the ejection fraction spectrum: clinical associations, medication use, and cause-specific outcomes: a contemporary, real-world analysis of the Swedish Heart Failure Registry.
Sweden tracks nearly everyone treated for heart failure, and this analysis covered 54,341 patients from 2017 to 2023, average age 73, and 34% women. Half had neither kidney disease...
GLP-1 Receptor Agonists, Lithium, and the Kidneys: A Tale of Two Signals.
This is a short commentary in a psychiatry journal about two drugs and the kidneys: GLP-1 medicines, the newer diabetes and weight drugs, and lithium, a mood medicine that can...
Renoprotective Effects of AdipoRon in Preclinical Models of Renal Injury: A Systematic Review and Meta-Analysis.
AdipoRon is an experimental drug that copies adiponectin, a hormone made by fat tissue. Researchers pooled the results of many laboratory studies and found it reduced signs of...
Causes and clinical outcomes of pregnancy-related acute kidney injury: A single-center tertiary hospital study in Abu Dhabi, United Arab Emirates.
Doctors looked back through hospital records at one center in Abu Dhabi, covering pregnant women who had sudden kidney failure between 2019 and 2023. The report describes what...
Effect of online hemodiafiltration on cardiovascular risk profile in children with end stage kidney disease.
38 children with kidney failure, 21 boys and 17 girls, were switched from standard dialysis to online hemodiafiltration, a version that filters the blood more thoroughly....
[Investigating mechanism of salt-fried processed Plantaginis Semen active component calceolarioside B in intervening lipid peroxidation metabolic pathway to exert anti-renal fibrosis effects].
Researchers tested calceolarioside B, a compound from the seed of a plantain herb, in rats whose kidneys were damaged on purpose to cause scarring. The treated rats had lower...
Complanatuside Ameliorates Renal Injury and Fibrosis in Chronic Kidney Disease by Inhibiting Tubular Cell Apoptosis via Activation of KLK1/BDKRB2.
Complanatuside is the main active compound in an astragalus seed extract used in Chinese medicine. In this lab work it reduced kidney damage and scarring by keeping tubule cells,...
Trends in type 1 and type 2 diabetic kidney disease in China, the USA, and the UK, 1990-2023.
Researchers compared kidney disease caused by type 1 and type 2 diabetes in China, the United States and the United Kingdom from 1990 to 2023, using the Global Burden of Disease...
[Systematic review and Meta-analysis of efficacy and safety of Kunxian Capsules in treatment of glomerular diseases].
This review pooled randomized trials of Kunxian Capsules, a Chinese herbal medicine, for glomerular disease, which is damage to the kidney's filtering units. The authors searched...
Navigating Kidney Cancer: Care Partner Communication with the Healthcare Team
This is a recorded National Kidney Foundation panel about how a care partner can talk with the medical team when someone has kidney cancer. The speakers include a person living...
Specific aspects of kidney care for Africans living in Europe.
This review covers kidney care for people of African descent living in Europe, who are more likely than others to reach advanced kidney disease and kidney failure. The authors...
Chronic Dehydration in Older Adults: A Silent Threat to Healthy Aging.
This review warns that slow, long-running dehydration in older adults is easy to miss. Its signs, such as weakness, constipation, headache, dizziness, unsteady walking and...
From population to individual: advocating personalised digital tools for heat-health early warning in a changing climate.
An opinion piece arguing that heat warning systems should be personalized to each person instead of issued to whole populations. It notes that heatwaves raise the risk of hospital...
Weight-Management Services for Patients With Advanced Chronic Kidney Disease in Canada: A Survey of Nephrologists.
Kidney doctors across Canada were surveyed about the weight-management help available to people with advanced kidney disease. Extra weight is common alongside kidney disease, and...
Osseointegration challenges of dental implants in dialysis-dependent chronic kidney disease patients
This article looks at why dental implants are harder to place in people on dialysis. Kidney failure changes bone and slows healing, so an implant may not lock into the jawbone the...
Intestinal Barrier Dysfunction in Chronic Kidney Disease: Insights from Aryl Hydrocarbon Receptor Signaling and Human Milk Oligosaccharide Intervention
Kidney disease can weaken the gut wall, which lets toxins leak from the gut into the blood. This work examines a cell signal system called the aryl hydrocarbon receptor and tests...
Genetic risk and telomere dynamics in chronic kidney disease associated with mitochondrial dysfunction and implications for Coenzyme Q10 therapy
This is a discussion paper, not a study with patients. It argues that inherited risk and aging cells may play a part in kidney disease through the tiny power plants inside cells,...
Associations of Plant- and Animal-Sourced Ultra-Processed Foods and Incident CKD in the Cardiovascular Health Study.
Researchers followed 2,661 adults aged 65 and older in the Cardiovascular Health Study to see who developed kidney disease. They split ultra-processed foods, meaning heavily...
Prenatal Heat Wave Exposure and Renal Function in Early Childhood: Findings from a Chinese Birth Cohort.
Researchers followed 1,278 mothers and their children in Fujian, China, to ask whether heat waves during pregnancy affect the child's kidney function in early childhood. They...
Olfactory dysfunction in hemodialysis patients: baseline differences and longitudinal changes compared with healthy controls.
This study tested the sense of smell in 100 people on regular dialysis and 52 healthy people, then tested them again later. The dialysis group scored worse from the start. This...
Body composition phenotypes are key predictors of cardiovascular-kidney-metabolic multimorbidity and long-term mortality: insights from a population-based cohort study
This study followed a large group of adults from the general population over many years. It sorted them by body composition, meaning how much fat and muscle they carry and where it...
Restless legs syndrome in hemodialysis and peritoneal dialysis: a propensity score-matched comparison.
This study compared two kinds of dialysis, hemodialysis and peritoneal dialysis, and how often patients had restless legs syndrome, a strong urge to move the legs at night that...
A Randomized Pilot Trial of a Nephrologist Communication Tool for Discussing Conservative Management.
Many people with kidney failure are never told about conservative management, which means treating symptoms and protecting quality of life without starting dialysis. This small...
The effect of a mobile game application on knowledge and health-related beliefs in children with chronic kidney disease: A randomized controlled trial.
Researchers built a mobile game for children aged 11 to 14 who have chronic kidney disease, then tested it in a randomized trial of 64 children, 32 in each group. They measured...
Pivotal Study of the Velocity™ pAVF System
A trial is opening for the Velocity System, a device that builds the vein-to-artery connection needed for dialysis. It works through a small needle puncture instead of open...
Adherence to KDOQI vessel preservation guidelines in chronic kidney disease: A 5-year retrospective single-institution review of device and vein selection
One hospital looked back over five years at how well its staff followed guidelines to protect the arm veins of people with chronic kidney disease. Those veins are needed later to...
Deep Learning-Based 3D Kidney Reconstruction from Freehand 2D Ultrasound with Applications to Volumetric Analysis
This is engineering work on software that builds a 3D picture of a kidney from ordinary handheld ultrasound scans. The aim is to measure kidney size and volume without sending...
From assistant to collaborator: A systematic review of the evolution of artificial intelligence in end-stage renal disease care and management.
Researchers read 100 published studies to map how artificial intelligence has been used in kidney failure care over time. They sort the tools into stages, from simple assistants...
eGenesis Announces Clinical Update in Ongoing Expanded Access Study…
The company eGenesis says five people with kidney failure have received its gene-edited pig kidney since March 2024, through a program that allows treatment outside a formal trial....
PROTEINURIA AFTER PIG KIDNEY XENOTRANSPLANTATION: A POTENTIAL UNIFYING HYPOTHESIS LINKING MECHANICAL, INNATE, AND ADAPTIVE INJURY PATHWAYS.
When gene-edited pig kidneys are put into monkeys, the new kidney often leaks a lot of protein into the urine, which is a sign of damage. This paper offers one theory to explain...
Effect of Melatonin Supplementation on Glycemic and Lipid Profiles in Kidney Transplant Recipients: A Clinical Trial.
A randomized trial in Tehran gave melatonin or a dummy pill to adults who had received a kidney transplant at least six months earlier. Neither the patients nor the staff knew who...
The Polycystic Kidney as a Staphylococcal Reservoir
A 55 year old woman with inherited kidney cysts (polycystic kidney disease) was being prepared for a transplant from a donor with a different blood type. After her 8th blood...
Machine learning models for early detection of urinary tract infections in kidney transplant patients.
Researchers built computer models to spot early which kidney transplant patients are heading for a urinary tract infection. Transplant patients take drugs that hold down the immune...
The Role of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker in Predicting the Function of Kidney Grafts: A Literature Review
Doctors want an early warning sign for whether a transplanted kidney will start working well. This review gathers past studies on a protein called NGAL, which the kidney releases...
Experience with early treatment using febuxostat in a patient with adenine phosphoribosyltransferase deficiency after pediatric kidney transplantation: a case report
A child who had a kidney transplant also had APRT deficiency, a rare inherited condition where the body makes crystals that damage the kidney. Doctors started febuxostat, a drug...
Beyond living donation: robot-assisted kidney transplantation using deceased-donor grafts-a scoping review of selection, ischaemia logistics, and allograft outcomes.
Surgeons are starting to use robots to place kidneys from donors who have died, not only from living donors. This review pulled together the studies done so far on who gets chosen,...
Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study.
A person with kidney failure faced a long wait for a human donor kidney, so doctors transplanted a pig kidney first, then later gave them a human kidney. The report follows what...
Kidney Health for All: Caring for People, Protecting the Planet.
An opinion piece arguing that today's kidney care model is failing: it waits until the disease is far along, then leans on dialysis in clinics, at high cost to patients and the...
Displaced people and kidney health.
This review gathers what is known about kidney disease in people driven from their homes by war and disaster. Kidney problems are a growing cause of illness in these groups, yet...
Safety incidents during intrahospital transport of hemodialysis patients in China: a multicenter cross-sectional study.
A survey of 4,253 nurses at large Chinese hospitals, including 418 head nurses, asked what goes wrong when dialysis patients are wheeled between departments inside the hospital....
Global trends and knowledge mapping of steroid-resistant nephrotic syndrome research: a bibliometric analysis
This paper counts and maps published research on steroid-resistant nephrotic syndrome, a kidney condition where the usual steroid treatment does not work. It tracks which...
Scientific Mapping of Research in Renal Nursing and Telehealth: A Bibliometric Study
This is a study of other studies, counting who publishes on kidney nursing and remote care and how those papers connect. It maps where the research field is growing. It does not...
Premenarche risk factors for future dysmenorrhoea: a prospective cohort study
This study followed girls before their first period to see what predicted painful periods later. It is an observational study, so it shows a link, not a cause. It has nothing to do...
Gender disparities in specialized nephrology care
This paper looks at whether men and women get equal access to specialist kidney care. Work like this compares groups as they already are, so it shows a gap, not the reason behind...
Cardiovascular–Kidney–Metabolic Syndrome Pharmacoeconomics, and the Journey to India-Specific Evidence
This is a commentary on the cost of treating the linked cluster of heart, kidney and metabolic disease, and it argues India needs its own cost data rather than borrowing numbers...
Association of home- and community-based services with incident chronic kidney disease among patients with diabetes: a longitudinal study of CHARLS
Researchers used a large long-running survey of older adults in China (CHARLS) to see whether people with diabetes who used home and community support services were less likely to...
Nurse training and completion of fluid balance chart documentation among patients with chronic kidney disease at Kiruddu National Referral Hospital. A cross-sectional study.
At one referral hospital in Uganda, researchers checked how completely nurses filled in fluid balance charts for kidney patients. A fluid balance chart records what a person drinks...
Patient-reported ratings of transfer to adult care among young adults with chronic kidney disease.
Teenagers and young adults with kidney disease have to move from a children's clinic to an adult one. This study asked them to rate how that handover went and looked at what made...
Meet the 2027 ISN Awards winners - International Society of Nephrology
The International Society of Nephrology named the winners of its 2027 awards for kidney research, teaching and care. Winners will be honored at the society's world congress in...