← brief for 2026-09-03 · Slowing decline

Uremic Serum Alters Gene Expression Profiles and Signaling Pathway Activity in Porcine Arterial Smooth Muscle Cells

Key takeaways

When kidneys fail, waste builds up in the blood, a state called uremia. Researchers bathed pig artery muscle cells in blood serum from that state and watched which genes switched on and off. Many genes tied to blood vessel damage and stiffening changed activity. This was done in cells in the lab, not in people, so it is an early clue about why kidney disease is hard on blood vessels.

Who did this work

Unimunkh Uriyanghai (University of North Carolina at Chapel Hill) · Huanjuan Su · John S. Poulton (University of North Carolina at Chapel Hill) · Gang Xi (University of North Carolina at Chapel Hill) · Lianxia Li (University of North Carolina at Chapel Hill) · Mihaela Mocanu (University of North Carolina at Chapel Hill) · Youyou Zheng (University of North Carolina at Chapel Hill) · Vinay A. Sudarsanam · Christine Wai (University of North Carolina at Chapel Hill) · Anthony Z. Yang (University of North Carolina at Chapel Hill) · Kenton Lee (University of North Carolina at Chapel Hill) · Prabir Roy-Chaudhury

Source

Paper · OpenAlex, CKD works · 2026-09-02
https://doi.org/10.17615/cd8t-pp89