Today in kidney research

Short- and mid-term outcomes of hemodialysis vascular access in pediatric patients.

This study looked at 50 children who needed dialysis. It tracked how well their dialysis access sites worked over time. The study found that some access sites failed or needed repair within a year. This shows a link between access type and complications, not proof of cause. It helps doctors choose the best access for children.

Risk factors associated with rapid progression of chronic kidney disease. A retrospective cohort study.

This study reviewed records of kidney disease patients in a hospital. It looked for factors that might cause kidney function to drop quickly. The study shows a link between certain risk factors and rapid decline, but it is not proof of cause. It helps identify who might be at higher risk.

Pragmatic Person-Centered Care for Diabetes in Myanmar: A Narrative Review and Expert Insights From an Advisory Board Meeting.

This is an expert opinion paper about how to care for people with diabetes in Myanmar. It discusses the challenges and cultural strengths of providing personalized care. There are no new study results in this paper. It is a discussion of best practices for diabetes management.

Trends in metabolic risk factor control and medication use among adults with type 2 diabetes in Taiwan, 2015-2024.

Researchers tracked health records in Taiwan for 10 years to see how well people with type 2 diabetes were managing their health. They found that more people were reaching their blood sugar and cholesterol goals over time. This shows a link between better care and improved health markers, but it does not prove that specific treatments caused the change.

Empagliflozin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Randomized Controlled Trial.

A small trial tested a diabetes drug called empagliflozin in people with polycystic kidney disease. The study ran for 12 months and found the drug was safe to use. However, the drug did not slow the growth of the kidneys. It also did not improve how well the kidneys filtered blood.

Sodium-Glucose Cotransporter 2 Inhibitor Use and Levels of Hemoglobin, Markers of Iron Metabolism, and Erythropoiesis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

This large review combined data from many clinical trials to look at a common diabetes drug. It found that people taking this drug had higher levels of hemoglobin, a protein in red blood cells. This is a strong finding because it is based on many studies. Higher hemoglobin can help the body carry oxygen better.

Renin-Angiotensin System (RAS) Inhibitors in High-Risk Patients With Type 2 Diabetes and Cardio-Renal Risk.

This study looked at records for 33,524 adults with type 2 diabetes. It checked how many were taking specific blood pressure drugs that help protect the kidneys. The results show a link between patient status and medication use, but they do not prove cause and effect. This type of review helps doctors see where care might be missing.

Periostin in diabetic kidney disease: mechanistic insights, biomarkers, and therapeutic perspectives.

This review looks at a protein called periostin that may play a role in kidney damage from diabetes. It summarizes research done in animals and cells, not in people yet. The goal is to find new targets for future drugs. This is early-stage science that helps us understand how the disease works.

Diuretic therapy at the heart–kidney interface: from acute decongestion to long-term de-escalation in heart failure with reduced ejection fraction

This is a review article about water pills for heart failure. It does not report new results. The topic is still being discussed, and there are no new findings here yet.

Practical Prevention of Heart Failure Across Stages A and B: A Scientific Statement From the Japanese Heart Failure Society.

This is a set of guidelines from a Japanese medical group. It offers advice on how to prevent heart failure in people at risk. It does not report new test results.

Jiedu Quyu Ziyin Decoction attenuates high-phosphate-induced calcification-associated phenotypes in cultured human aortic smooth muscle cells.

This study tested a traditional Chinese medicine in a lab. It looked at how the medicine affects hardening of blood vessels. This was done in cells, not in people yet.

Preoperative parathyroid imaging in CKD-related secondary hyperparathyroidism: a systematic review and diagnostic test accuracy network meta-analysis.

This large review compared different scans used to find overactive parathyroid glands. It looked at people with kidney disease who need surgery. It helps doctors pick the best scan to use.

Methyldigoxin-Induced Visual Hallucinations in an Elderly Patient with Advanced Fazekas Scale 3 Leukoaraiosis: A Diagnostic Challenge and Case Report.

This is a report on one patient who had visual hallucinations. It happened after starting a heart medicine. It is a single case, not a large study.

Race-Free Equations and Cardiovascular Risk Assessment: Much Ado About Something.

This review discusses how to calculate kidney function without using race. It looks at how this change affects heart risk scores. It is a discussion, not a new trial.

Evaluation of the preventive effect of intravenous trans-sodium crocetinate followed by oral crocetin on contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angioplasty: A randomized placebo-controlled triple-blind clinical trial.

A trial of 130 people found a plant-based antioxidant helped protect kidneys. The medicine was given before a heart scan. It may lower the risk of kidney damage from the dye.

Palopegteriparatide: Parathyroid Hormone Analog for the Treatment of Chronic Hypoparathyroidism in Adults.

This is a review of a new drug for low parathyroid hormone. It summarizes what is known about the medicine. It does not report new trial results.

Early Manifestations of Granulomatosis With Polyangiitis: A Case Report.

This is a report on one person with a rare autoimmune disease. It describes how the disease first showed up. It is a single case, not a large study.

Clinical Trial of Tolvaptan in Pediatric ADPKD: Two-Year, Open-Label Extension.

This is a follow-up to a trial of a drug called tolvaptan. The drug is used for a genetic kidney disease. This part of the study lasted two years. It looked at safety and kidney function in children. The study was small, involving only the children who finished the first part of the trial.

Circulating miRNA-21 and Biomarkers of Inflammation, Fibrosis, and Oxidative Stress in Adults with Type 2 Diabetes Mellitus: A Cross-Sectional Study.

This study looked at blood markers in people with type 2 diabetes. It found a link between a specific molecule and signs of kidney stress. This is a cross-sectional study, so it shows a link, not proof of cause.

Acquired Cystic Disease-Associated Renal Cell Carcinoma: Recurrent Copy-Number Patterns and Overlap With Papillary Renal Cell Carcinoma.

This study looked at the genes in 14 kidney tumors. These tumors grew in people with end-stage kidney disease. It found common patterns in the tumor cells. This was a lab study of tissue samples, not a test in people.

Warfarin After Seven Decades: Persistent Value and the Contemporary Role of Vitamin K Antagonism

This review looks at when the blood thinner warfarin is still the best choice. It notes that for people with mechanical heart valves, warfarin is required. Newer drugs have not worked as well in these specific cases. This is a summary of existing evidence, not a new trial with fresh results.

Perioperative Risk Factors and Development of a Clinical Risk Score for Postoperative Acute Kidney Injury in Patients Undergoing Lower Limb Amputation for Vascular Disease

Researchers looked at 101 people who had a leg amputation for blood vessel disease. They found that certain factors, like low blood pressure during surgery, linked to kidney injury. This study shows a link, but it is not proof of cause. It helps doctors spot who is at higher risk.

Acute eGFR Changes With Finerenone Examined in a Prespecified Analysis of FINE-ONE.

This analysis looked at 242 people with type 1 diabetes and kidney disease. They were given the drug finerenone or a placebo. The drug caused a small, temporary drop in kidney filtering rate in the first month. This drop reversed after the treatment ended, suggesting it is a safe side effect.

[Renal function assessment and procedure selection in metabolic and bariatric surgery].

This review discusses how to check kidney health before weight loss surgery. It explains that kidney function tests can be tricky in people with obesity. There are no new results in this piece, just a summary of current knowledge.

Evaluating the role of metabolic surgery versus GLP1 agonists in patients living with obesity and chronic kidney disease - a systematic review.

This review looked at 6 studies comparing weight loss surgery and GLP-1 drugs. It found that both options can protect the kidneys in people with obesity and diabetes. This is a high-level summary of existing evidence.

Qimei Granules Alleviate Symptoms in Chronic Pancreatitis with Jueyin Disease: A Randomized Double-Blind Placebo-Controlled Trial.

This trial tested a traditional Chinese medicine called Qimei Granules in 102 people with chronic pancreatitis. The treatment lasted six weeks. The study found that the medicine helped reduce symptoms compared to a placebo. It is a small trial, so the results need more confirmation.

2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part IV) on Comprehensive Lifestyle Risk Factor and Comorbidity Management in Atrial Fibrillation.

This is a set of new guidelines for doctors. It covers how to manage lifestyle habits in people with a common heart rhythm problem. The guidelines mention kidney disease as a related health issue. There are no new study results in this document.

Medicinal plants and functional foods with diuretic effects: A nutraceutical approach to cardiovascular health.

This is a review of existing research on plants and foods. It looks at how they might help with fluid balance in the body. It mentions kidney disease as a reason to manage fluid. There are no new trial results in this review.

Are oral and intravenous vitamin C implicated in oxalate-associated renal failure? Exploring the role of pre-existing renal dysfunction.

This review looked at 45 reports of people who had kidney failure after taking vitamin C. It found that most of these people already had weak kidneys. This suggests that vitamin C can be risky for people with existing kidney issues. This is a review of case reports, so it shows a link, not proof of cause.

Dietary sodium intake and kidney tubular protein abundance in urinary extracellular vesicles.

Forty-six healthy adults with normal kidney function tried a very low salt diet, then a high salt diet. The study measured proteins in their urine to see how the kidneys handled salt. It found that salt intake changed the amount of certain kidney proteins. This was a small test, so the results need more study to be sure.

Disease trajectories and lived experiences of patients with X-linked hypophosphatemia in Taiwan: a qualitative study.

This study interviewed 15 patients in Taiwan about their daily lives with a rare kidney disorder. It describes the physical and emotional challenges they face. There are no numerical results or treatment outcomes, just personal experiences.

Peritoneal M2 macrophage-derived extracellular vesicles as a nanotherapeutic for immune-oxidative microenvironment reprogramming in IgA nephropathy.

This study was done in mice, not people yet. It tested a new cell therapy for a common kidney disease. The therapy helped reduce protein in the urine and scarring. It is a promising step, but more testing is needed.

Paclitaxel-induced scleroderma: A scoping review of reported cases with an illustrative case from our center.

This review looked at published cases of a rare skin condition caused by a chemotherapy drug called paclitaxel. It includes a new case from the authors' center. The study shows a link between the drug and the skin condition, but it is not proof of cause. It helps doctors recognize this side effect.

Ganoderic acid A attenuates streptozotocin-induced diabetic kidney injury: associations with mitochondrial oxidative stress and TGF-β/Smad signaling.

This study tested a compound called Ganoderic acid A in cells and animals. It looked at how the compound affects kidney damage caused by diabetes. The study was done in the lab and in animals, not in people yet. It suggests the compound might protect kidneys, but more testing is needed.

Renal vascular malformation with features suggestive of arteriovenous shunting presenting as hemorrhagic medullary cyst-like lesions: a clinicopathologic diagnostic pitfall

Mesenchymal stem cell-derived exosomes alleviate renal interstitial fibrosis via pVHL-mediated HIF-1α ubiquitination and degradation

This study tested tiny particles from stem cells in cells and animals. The particles helped reduce scarring in the kidney. This was done in a lab setting, not in people yet.

Sodium-Glucose Cotransporter-2 Inhibitor Use in Kidney Transplant Recipients With Post-Transplantation Diabetes Mellitus - A Cross-Sectional Study.

This study looked at kidney transplant patients in Norway who developed diabetes after their surgery. It checked if a common diabetes drug called an SGLT2 inhibitor helped their bodies process sugar better. The results show a link between using this drug and a healthier metabolic profile. However, this type of study cannot prove that the drug caused the improvement.

Correction: Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass for Obese Kidney Transplant Candidates: A Systematic Review, Meta-Analysis, and Development of a Transplant-Specific Decision Framework

This is a correction notice for a previous review. It does not report new results. The original study is still being discussed, and there are no new findings here yet.

Long-term cost-effectiveness of CKD screening in middle-aged adults.

This study used a computer model to estimate the cost of screening for kidney disease in Finland. It looked at whether finding the disease early and treating it with new drugs would save money over time. The model suggests that early screening is a good use of healthcare funds. This is a prediction based on data, not a test on real people.

Compounded GLP-1 Dispensing Patterns and Vitamin B12 Coformulation.

This study looked at prescription data for weight-loss drugs that are mixed in pharmacies. It found that many of these drugs are made with extra ingredients like vitamin B12. It also looked at how often people pay for them out of pocket. This shows how these drugs are being sold and used in the market.

Practical recommendations for the implementation of the Kidney Failure Risk Equation in a clinical laboratory setting

This document gives advice to labs on how to use a specific math formula to predict kidney failure. It is a set of guidelines for how to run the test, not a new study with results. It helps standardize how this tool is used in clinics.

Supplementary material for: Context-Dependent effects of FTO-Mediated m6A demethylation in inflammation-related chronic kidney disease (systematic review and meta-analysis)

This is a data file that holds extra tables and figures for a larger review. It does not report new results on its own. The main study is still being discussed, and there are no new findings here yet.

Sonographic Renal Cortical Thickness and Echogenicity as Correlates of Estimated Glomerular Filtration Rate in Chronic Kidney Disease: A Cross-sectional Study from North-western Nigeria

This study looked at 106 people with kidney disease and 106 healthy controls. It found that a simple ultrasound can show how thick the kidney tissue is. Thinner tissue linked to lower kidney filtering rates. This shows a link, not proof of cause.

Associations between perceived discharge planning quality, patient capability, self-management, and quality of life in maintenance haemodialysis: a cross-sectional PLS-SEM study

This study surveyed 370 people on dialysis in Indonesia. It found that better discharge planning linked to higher quality of life. This shows a link, not proof of cause.

Endogenous panophthalmitis in a patient with diabetic kidney disease on haemodialysis: A vision-threatening manifestation of systemic infection

This is a case report about one person on dialysis. It describes a rare eye infection from a bloodstream bug. It does not report new results from a larger group. There are no new findings here yet.

Nitrous Oxide-Associated Rhabdomyolysis With Acute Kidney Injury Requiring Hemodialysis

This is a case report about one person. It describes a rare kidney injury from a gas used in dentistry. It does not report new results from a larger group. There are no new findings here yet.

BD2: Insulin timing and glucose-trajectory phenotypes in sepsis-associated acute kidney injury - analysis code

This is a data file that holds the code used to analyze a study. It does not report new results on its own. The main study is still being discussed, and there are no new findings here yet.

Penile Necrosis in a Patient With End-Stage Kidney Disease: Suspected Uremic Calciphylaxis in the Setting of Severe Peripheral Arterial Disease

This is a case report about one person with end-stage kidney disease. It describes a rare skin condition. It does not report new results from a larger group. There are no new findings here yet.

Type of dialysis may influence the prognostic value of myocardial perfusion imaging in end stage renal disease: an observational [13N]NH3 PET/CT study

This study looked at 41 people with kidney failure who were waiting for a transplant. It used a special heart scan to check blood flow. The goal was to see if the scan works the same for people on different dialysis types. This is an observational study, so it shows a link, not proof of cause.

Gut microbiota and CKD-related kidney function: multistage Mendelian randomization

Characterization and analysis of osseous changes in murine jaws induced by chronic metabolic acidosis

This study used mice to model a condition where the body becomes too acidic. This often happens in kidney disease. The researchers found that the upper jaw bone was more damaged than the lower jaw. This was done in animals, not people yet.

An Audit on the Management of Adult Patients With Renal Colic Presenting to the Emergency Department

New-Onset Seizures and Acute Renal Failure: An Atypical and Severe Sarcoidosis Presentation

Dataset for systematic review and meta-analysis of acute kidney injury and delirium in acutely ill adults

This is a data file for a review of past studies. It looks at the link between sudden kidney injury and confusion. It is a data set, not a new study with results.

Comparative analysis of international guidelines for the management of chronic kidney disease mineral and bone disorder

Analysis code and source result files for: Urinary PAH biomarkers and kidney function: sensitivity to dilution adjustment and outcome definition in NHANES 2005–2016

This item is a file that holds the computer code used to analyze a study. The study looked at urine markers and kidney function. This file does not report new health findings. It is a tool for researchers to check the work.

Integrated assessment of Hepatic, Renal, and Vitamin D status in Iraqi patients with Diabetic foot ulcer

This study compared people with diabetic foot sores to healthy people. It checked their liver, kidney, and vitamin D levels. This is an observational study, so it shows a link, not proof of cause.

Mapping cardiometabolic risk in Cleveland's urban environment: A participatory systems analysis of place-based drivers and the role of Community Health Workers.

This study looks at how living in a low-income area affects health. It focuses on how community workers can help people in Cleveland. It does not report new medical test results.

[Proposal to strengthen network-based care for patients with kidney disease through the implementation of HEARTS 2.0 in ChileProposta para fortalecer a atenção em rede a pacientes com doença renal por meio da implementação da iniciativa HEARTS 2.0 no Chile].

This paper proposes a new way to organize kidney care in Chile. It aims to help doctors catch problems early. It is a plan, not a study with results.