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Plasma FGF23 and cardiovascular mortality in relation to kidney function among adults with established cardiovascular disease

Key takeaways

In adults who already had heart disease, higher blood levels of a hormone called FGF23 went along with a greater chance of dying from heart problems. FGF23 rises as the kidneys handle phosphate less well, and the link was examined across different levels of kidney filtering rate (eGFR). This is an observational study, so it shows a link, not proof that FGF23 causes the deaths. It adds to the case that failing kidneys and heart risk are tightly tied together.

Who did this work

Yue Luo (Wenzhou Medical University) · Yuezhong Huang (Wenzhou Medical University) · XU Qin-xuan (Wenzhou Medical University) · Yi-Hao Bian (Wenzhou Medical University) · Yuhong Huang (Wenzhou Medical University) · Yifan Shen (Wenzhou Medical University) · Hongzi Song (Wenzhou Medical University) · Zhixiu Li (Southern University of Science and Technology) · Weihong Song (Zhejiang Lab) · Xiu‐Feng Huang (Wenzhou Medical University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-02
https://doi.org/10.1186/s12872-026-06554-6