← brief for 2026-09-03 · Slowing decline

BRD2-Mediated TGR5 Destabilization Impairs Fatty Acid Oxidation and Drives Tubular Ferroptosis in Diabetic Kidney Injury.

Key takeaways

In diabetic mice, a protein called BRD2 built up over time in the kidney tubules, the tiny tubes that reclaim fluid and salt. The extra BRD2 broke down TGR5, a receptor that helps kidney cells burn fat for energy. Starved of fuel, the cells died through iron driven damage called ferroptosis. This was in mice and cells, not people yet, so it points at a possible drug target and nothing more.

Who did this work

Zang H · Zang F · Zhang H · Lei Y · Jiang Y · Li Y · Tang D · Wang D · Xiao F

Source

Article · PubMed, fibrosis reversal · 2026 Sep 3
https://pubmed.ncbi.nlm.nih.gov/42685932/