← brief for 2026-09-03 · Nutrition & lifestyle

Intestinal Barrier Dysfunction in Chronic Kidney Disease: Insights from Aryl Hydrocarbon Receptor Signaling and Human Milk Oligosaccharide Intervention

Paper D Peer reviewed Preclinical

Key takeaways

Kidney disease can weaken the gut wall, which lets toxins leak from the gut into the blood. This work examines a cell signal system called the aryl hydrocarbon receptor and tests sugars found in human breast milk as a way to repair that barrier. It was done in cells and lab models, not in people. It points at a possible future target, not something anyone can act on now.

Who did this work

Avra Madella · Afd Pharmacology · Johan Garssen · Roos Masereeuw · Saskia Overbeek · Jeroen van Bergenhenegouwen

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-02
https://openalex.org/W7205651983