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Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy

Key takeaways

This is a review article about how scarring builds up in organs, including the kidney. It argues that physical stress on cells feeds back and drives more scarring, and it proposes cut-off points for when to treat. It is a discussion of ideas and past work, not a new experiment, so there are no results yet.

Who did this work

Amedeo Lonardo (University of Modena and Reggio Emilia) · Ralf Weiskirchen (RWTH Aachen University)

Source

Paper · OpenAlex, CKD works · 2026-09-01
https://doi.org/10.1002/ccs3.70111