← brief for 2026-09-03 · Slowing decline

Association of cumulative cholesterol-HDL-glucose index with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

Key takeaways

This nationwide study followed adults with early stage heart, kidney and metabolic problems, called stages 0 to 3. It tracked a combined score built from cholesterol, good cholesterol (HDL) and blood sugar, added up over several years, and checked who later had heart disease. People whose score stayed high over time had more heart events. This shows a link, not proof of cause, and the study did not test whether lowering the score helps.

Who did this work

H Wang (Nanjing University of Chinese Medicine) · Xinyu Wang (Nanjing University of Chinese Medicine) · Xinyu Wang (Nanjing University of Chinese Medicine) · Yadi Wu (Nanjing University of Chinese Medicine) · Yunzhao Cao (Nanjing University of Chinese Medicine) · Sizhuo Zhou (Nanjing University of Chinese Medicine) · Jiadong Liang (Nanjing University of Chinese Medicine) · Yuxing Wang (Nanjing University of Chinese Medicine) · Zilin Li (Nanjing University of Chinese Medicine) · 朱洛英 (Nanjing University of Chinese Medicine) · 朱洛英 (Nanjing University of Chinese Medicine) · Jingyi Ma (Nanjing University of Chinese Medicine)

Source

Paper · OpenAlex, CKD works · 2026-09-01
https://doi.org/10.1038/s41598-026-67671-y