← brief for 2026-09-03 · Slowing decline

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Key takeaways

Researchers studied a protein called Cullin 3 in proximal tubule cells, the kidney cells that pull water and salts back out of urine. They report that it helps set how those cells defend themselves against damage from unstable oxygen molecules, and how they make energy. This was done in cells and lab models, not in people. It points at a possible target for future drugs, but nothing here can be used as a treatment yet.

Who did this work

Turgay Saritas (Erasmus MC) · Lu Chen (Düsseldorf University Hospital) · Sadaf Ijaz (Düsseldorf University Hospital) · Susanne Ziegler (Düsseldorf University Hospital) · Aurelien Dugourd (Heidelberg University) · Xiaohang Shao (Düsseldorf University Hospital) · Jonathan Ulrich (Düsseldorf University Hospital) · Claire Koenig (Novo Nordisk Foundation) · Giulia Franciosa (Novo Nordisk Foundation) · Ilaria Piga (Novo Nordisk Foundation) · Jesper V. Olsen (Novo Nordisk Foundation) · Rebekka Schneider-Kramann (Erasmus MC)

Source

Paper · OpenAlex, CKD works · 2026-09-02
https://doi.org/10.1093/ndt/gfag202