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Finerenone Added to Renin-Angiotensin System- and Sodium-Glucose Cotransporter 2 Inhibition in Patients with Alport Syndrome: A Two-Center Case Series.

Key takeaways

Alport syndrome is an inherited kidney disease that often leads to kidney failure. Some people keep losing kidney function even on both standard drug types: blood pressure drugs that block the renin angiotensin system, and SGLT2 inhibitors. Doctors at two centers added finerenone, which blocks a salt regulating hormone receptor, and tracked protein in the urine plus side effects. Mouse studies had suggested it would help, but this is a small case series with no comparison group, so it shows a link at best, not proof the drug worked.

Who did this work

Boeckhaus J · Wang F · Ding J · Jami S · Zhang Y · Gross O

Source

Article · PubMed, the drug frontier · 2026 Sep 2
https://pubmed.ncbi.nlm.nih.gov/42684838/