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Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications.

Key takeaways

This review argues the liver belongs alongside the heart, kidneys and metabolism as one linked condition rather than four separate problems. Large group studies show that people who have both fatty liver disease and chronic kidney disease carry more risk than people with either one alone. Those studies follow people over time without assigning treatment, so they show a link, not proof that the liver damage causes the kidney damage. The review also asks which treatments might protect several of these organs at once.

Who did this work

Marshall WR · Sinha S · Green D · Kalra PA

Source

Article · PubMed, the drug frontier · 2026 Sep 2
https://pubmed.ncbi.nlm.nih.gov/42683763/