← brief for 2026-09-03 · Transplant & xeno

Experience with early treatment using febuxostat in a patient with adenine phosphoribosyltransferase deficiency after pediatric kidney transplantation: a case report

Key takeaways

A child who had a kidney transplant also had APRT deficiency, a rare inherited condition where the body makes crystals that damage the kidney. Doctors started febuxostat, a drug that blocks the chemical those crystals are made from, early after the transplant. This is a single case report: one patient, written up by their own team. It describes what happened to that child and cannot show the drug works for anyone else.

Who did this work

Yujiro Aoki (Toho University) · Maho Maeda (Toho University) · Junya Hashimoto (Toho University) · Ayuko Zaitsu (Toho University) · Kazuyuki Ueno (Toyama Prefectural Central Hospital) · Satoshi Furukawa (Toho University) · Satoru Ochiai (Toho University) · Kei Sakurabayashi (Toho University) · Takashi Yonekura (Toho University) · Yoshihiro Itabashi (Toho University) · Masaki Muramatsu (Toho University) · Takeshi Kawamura (Toho University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-02
https://doi.org/10.1007/s13730-026-01176-5