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Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics and the Pharmacokinetics of Balcinrenone When Dosed with a P-gp Inhibitor.

Key takeaways

Balcinrenone is a new drug that blocks the same hormone receptor as older drugs like spironolactone, but is designed to be gentler. It is being developed as one pill combined with dapagliflozin, an SGLT2 inhibitor already used to slow kidney disease. This early stage randomized study tested whether food changes how much drug reaches the blood, and what happens when it is taken with a drug that blocks a transporter called P-gp. Each person took the drug three ways in random order; the abstract does not say how many people took part, and the study measured blood levels only, not kidney outcomes.

Who did this work

Eriksson AL · Karsanji D · Shi AH · Parkinson J · Heijer M · Austin E · Lindmark B · Vedin-Nilsson C · Hartleib-Geschwindner J · Leonsson-Zachrisson M · Ericsson H

Source

Article · PubMed, CKD nutrition RCTs · 2026 Sep
https://pubmed.ncbi.nlm.nih.gov/42687606/