← brief for 2026-09-03 · Slowing decline

Preoperative SGLT2 Inhibitor Use and Outcomes After Major Cardiac Procedures: A Propensity Score-Matched Analysis of the TriNetX Network

Key takeaways

SGLT2 inhibitors are diabetes drugs that also slow kidney decline. This study used a large hospital records network to compare people who were taking one before major heart surgery with similar people who were not. The two groups were matched so they looked alike on paper, but this is still record-keeping, not a trial. It shows a link between taking the drug and how people did, not proof that the drug caused the difference.

Who did this work

Mirza Muhammad Hadeed Khawar (Services Institute of Medical Sciences) · Faizan Ahmed (Jersey Shore University Medical Center) · Mohab Elnashar (University of Arkansas for Medical Sciences) · Cheryl Vanessa Lewis (Tbilisi State Medical University) · Minahil Shahid (Shalamar Hospital) · Ali Asgher Shuja (Habib University) · Fatima Afzal (Memorial Medical Center) · Naheed Sajjad (Sardar Bahadur Khan Women's University) · Muhammad Amir Khan (Ferghana Polytechnical Institute) · Meeran Atta (Services Institute of Medical Sciences) · Umair Arshad (Services Institute of Medical Sciences) · Muneeb Khawar (Services Institute of Medical Sciences)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-02
https://doi.org/10.3390/jcm15176808