← brief for 2026-09-03 · Slowing decline

Rapidly progressive steroid-resistant focal segmental glomerulosclerosis associated with an INF2 exon 6 variant.

Key takeaways

A boy had protein in his urine at age 12 and was diagnosed at 14 with FSGS, a scarring of the kidney's filters. Steroids, other immune drugs, and plasma exchange all failed, and his kidney function fell fast. Doctors then found a rare change in a gene called INF2, which is known to cause inherited FSGS. This is a report on one patient, so it shows a link between the gene change and the fast decline, not proof of cause.

Who did this work

Watanabe S · Tanaka K · Ishikawa T · Nishiyama T · Otsuki Y · Saito H · Kimura H · Ono A · Kazama JJ

Source

Article · PubMed, CKD progression · 2026 Sep 2
https://pubmed.ncbi.nlm.nih.gov/42684599/