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Cell-state- and compartment-dependent PI3K/Akt redox signaling in chronic kidney disease: mechanisms and translational implications

Paper No results yet Peer reviewed

Key takeaways

This is a review article, not a new study, so it reports no results of its own. It gathers what is known about a cell signaling pathway called PI3K/Akt and how it responds to damage from unstable oxygen molecules in chronic kidney disease. The authors argue the effect changes depending on which kidney cell you look at and which part of the cell. Nothing here has been tested as a treatment.

Who did this work

Jianzong Xuan (Anyang Hospital of Traditional Chinese Medicine) · Renhua Ding (Anyang Hospital of Traditional Chinese Medicine) · Haiyin Zhang (Anyang Hospital of Traditional Chinese Medicine) · Yiyuan Wang (Anyang Hospital of Traditional Chinese Medicine) · Lijuan Wu (Anyang Hospital of Traditional Chinese Medicine) · Yuan Liu (Anyang Hospital of Traditional Chinese Medicine) · Jianrui Dong (Anyang Hospital of Traditional Chinese Medicine) · Ran Hu (Anhui University of Traditional Chinese Medicine)

Source

Paper · OpenAlex, CKD works · 2026-09-02
https://doi.org/10.3389/fphar.2026.1951798