← brief for 2026-09-03 · Slowing decline

Antiproteinuric effect of dapagliflozin attenuates tubule-interstitial injury development in subclinical acute kidney injury animal model

Key takeaways

Animals with early, silent kidney injury were given dapagliflozin, a diabetes drug that makes the kidneys pass extra sugar into the urine. The drug cut the amount of protein leaking into the urine and reduced damage to the filtering tubes and the tissue around them. Protein in the urine is one of the strongest warning signs of kidney decline. This was done in animals, not people yet.

Who did this work

Rodrigo A.S. Peres (Universidade Federal do Rio de Janeiro) · Ana Carolina Pinto-Figueiredo (Universidade Federal do Rio de Janeiro) · Douglas E. Teixeira (Universidade Federal do Rio de Janeiro) · Rodrigo P. Silva-Aguiar (Universidade Federal do Rio de Janeiro) · Sarah A. S. Alves (Universidade Federal do Rio de Janeiro) · GIULIANNE BASTOS SERPA (Universidade Federal do Rio de Janeiro) · Carlos P. Gomes (Universidade Federal do Rio de Janeiro) · Wagner B. Dias (Universidade Federal do Rio de Janeiro) · Ana Acácia S. Pinheiro (Universidade Federal do Rio de Janeiro) · Celso Caruso‐Neves (Universidade Federal do Rio de Janeiro)

Source

Paper · OpenAlex, CKD works · 2026-09-01
https://doi.org/10.3389/fphar.2026.1899334