← brief for 2026-09-03 · Slowing decline

Protective association of the <i>ELMO1</i> rs741301 variant against diabetes mellitus and diabetic nephropathy: a systematic meta-analysis of case-control studies.

Key takeaways

This pooled analysis combined earlier studies that compared people who did and did not have diabetes and kidney damage caused by diabetes. It focused on one common gene difference, called ELMO1 rs741301. People carrying that version of the gene appeared less likely to develop diabetes and diabetic kidney disease. The pooled studies were observational comparisons, so this shows a link and not proof that the gene protects kidneys, and it changes nothing about treatment today.

Who did this work

Thomas SM (Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India.) · Anilkumar AS (Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India.) · Veerabathiran R (Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India.)

Source

Paper · Europe PMC, CKD · 2026-09-02
https://doi.org/10.1080/03014460.2026.2723114