Kidney research, 2026-09-16
New guidelines offer clearer steps for managing anemia in stage 3 kidney disease
Today’s updates focus on practical clinical guidance for anemia management in chronic kidney disease, with strong evidence supporting careful use of iron and blood-boosting drugs. Research on preventing kidney injury after heart surgery emphasizes combining strategies rather than relying on one fix. Several smaller studies hint at possible kidney recovery or protective mechanisms, but all need much more testing before changing routine care.
Predictors of survival and renal replacement therapy in anca-associated vasculitis with renal involvement: An 11-year real-world cohort from North Macedonia.
This study looked back at 11 years of records from North Macedonia's national kidney center. It covered adults with ANCA vasculitis that had reached the kidneys. This is a rare...
Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.
This study followed hospital patients in several countries who had liver inflammation caused by alcohol (alcohol-associated hepatitis). It checked whether sudden kidney injury, and...
Risk prediction of PLA2R-Ab-negative membranous nephropathy: an interpretable multicenter machine learning model
Researchers at several hospitals built a computer model to predict how a kidney disease called membranous nephropathy will go. The model is for people whose blood tests negative...
Vascular Quality Initiative Based Risk Score for Mortality within 3 Years of Revascularization for Chronic Limb Threatening Ischemia in End Stage Renal Disease Patients on Dialysis.
Researchers used a US registry of 38,144 people on dialysis who had surgery to restore blood flow to badly blocked legs. From those records, they built a score to predict who is...
Nephroprotective Effects of Citrus spp. Fruit-Cuticle Extracts, Melatonin, and Hydrochlorothiazide on HgCl₂-Induced Acute Renal Failure in Albino Rats
Researchers tested whether citrus peel extract, melatonin, or the blood pressure pill hydrochlorothiazide protected rats from sudden kidney failure caused by mercury poisoning....
Progression of coronary artery calcification in chronic kidney disease: nonlinear associations with serum magnesium and parathyroid hormone
This study followed people with kidney disease to see how calcium buildup in the heart's arteries grows over time. It looked at how that growth relates to blood magnesium and...
Inpatient outcomes after primary total knee arthroplasty in patients receiving chronic dialysis: A nationwide propensity score-matched analysis
This study used US hospital records to compare how people on long-term dialysis do in the hospital after a knee replacement, versus similar people not on dialysis. It shows links...
Prevalence and associated factors of chronic kidney disease–associated pruritus in maintenance hemodialysis patients: a systematic review and meta-analysis
This study pooled earlier studies to estimate how common itchy skin from kidney disease (CKD-associated pruritus) is among people on long-term hemodialysis, and what goes along...
Role of the Gut–Liver–Kidney Axis in Disease Manifestation and Biomarker Alterations
This is a review article on how the gut, liver, and kidneys affect each other in disease. It also covers how that link changes lab markers used to track illness. A review sums up...
Comprehensive trends in Chronic Kidney Disease prevalence and comorbidities across eGFR and albuminuria categories: a 20-year analysis of NHANES data
This analysis used 20 years of NHANES, a large US national health survey, to track how common chronic kidney disease is. It also tracked which other health problems come with it,...
Therapeutic Potential of Pirfenidone in Adenine-Induced Chronic Kidney Disease: An Integrated Experimental and In Silico Study
This study tested pirfenidone, an existing anti-scarring drug used for lung disease, in animals given kidney disease with a chemical called adenine. It also used computer modeling...
Quercetin Alleviates Ferroptosis-Induced Renal Fibrosis by Modulating the PRDM9/HMOX1/PTGS2 Axis
This lab study reports that quercetin, a natural compound found in foods like onions and apples, reduced kidney scarring (fibrosis). The authors link the effect to blocking...
PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies
This review pulls together research on PRDM16, a protein that switches genes on and off, as a possible drug target in kidney disease. The evidence it covers comes mostly from lab...
Beyond cardiovascular risk: integrating kidney health into the life-course approach to hypertensive disorders of pregnancy
This is a review and opinion piece, not a new study. It argues that women who had high blood pressure during pregnancy should also have their kidney health checked over the rest of...
Clinical Characteristics and Independent Risk Factors for Early Reocclusion Following Endovascular Intervention in Patients with Diabetic Foot Complicated by Lower Extremity Atherosclerotic Occlusive Disease: A Retrospective Cohort Study
This preprint, meaning it has not passed peer review, looked back at people with diabetic foot problems whose leg arteries closed up again soon after a procedure to reopen them. It...
Association between fibroblast growth factor 23 and left ventricular hypertrophy in Egyptian patients on regular hemodialysis
This study of Egyptian patients on regular dialysis looked at FGF23 and a thickened heart wall. FGF23 is a hormone that rises as the kidneys fail, and a thick heart wall is a...
Dialysis-requiring acute urate nephropathy and mobilization gout flare in a patient with alcoholic ketoacidosis: a case report
This case report describes one person whose kidneys suddenly failed and needed dialysis. Uric acid crystals built up in the kidneys during a crisis caused by heavy drinking, and a...
Histological grading of tertiary lymphoid structures correlates with renal impairment and adverse outcomes in ANCA-associated glomerulonephritis
In ANCA vasculitis affecting the kidney, some biopsies contain small clusters of immune cells. This study graded those clusters and found that higher grades went along with worse...
Preoperative identification of adverse pathology in clinically localized clear cell renal cell carcinoma: development and external validation of a contrast-enhanced ultrasound-based model
Researchers built an ultrasound-based tool to predict, before surgery, which early kidney cancers look aggressive under the microscope. It was checked on a separate group of...
Anticoagulant-Related Nephropathy Associated with Vitamin K Antagonists and Direct Oral Anticoagulants: Epidemiology, Pathophysiology, Clinical Features, and Outcomes
This is a review article about kidney injury linked to blood thinners, both warfarin-type drugs and newer ones like apixaban. In this kind of injury, bleeding inside the kidney...
Prognostic value of serum total bilirubin-lipid ratios in patients with IgA nephropathy
This study asked whether the ratio of bilirubin (a yellow pigment made when old red blood cells break down) to blood fats can predict how IgA nephropathy will go. IgA nephropathy...
Deep Vein Thrombosis and Pulmonary Embolism in Patients with Kidney Diseases
This is a book chapter about blood clots in people with kidney disease. It covers clots in the deep leg veins (deep vein thrombosis) and clots that travel to the lungs (pulmonary...
Serum uric acid variability and short-term mortality in chronic kidney disease: a retrospective cohort study with independent replication in MIMIC-IV
This study looked back at hospital records to see whether big swings in uric acid levels in the blood were tied to a higher risk of dying soon among people with chronic kidney...
Apolipoprotein A-IV deficiency rewires renal fibroblast states and intercellular communication during early obesity-associated chronic kidney disease
This lab study looks at what happens to the kidney's scar-forming cells (fibroblasts) when a blood protein called apolipoprotein A-IV is missing. It focuses on early kidney disease...
Epidemiology, mechanisms and clinical implications of heat-related kidney disease
This is an expert review in Nature Reviews Nephrology about how extreme heat can harm the kidneys. The authors explain how the body handles heat and look at the evidence tying heat...
Association Between Serum Homocysteine and Chronic Kidney Disease Severity in Vietnamese Outpatients With Type 2 Diabetes: A Cross-Sectional Study.
Researchers in Vietnam measured homocysteine, an amino acid in the blood, in outpatients with type 2 diabetes. They checked whether higher levels went along with worse kidney...
Twelve-month real-world outcomes of sparsentan in a multicenter Spanish IgA nephropathy cohort.
Doctors across several centers in Spain looked back at records of people with IgA nephropathy who took sparsentan in everyday care. IgA nephropathy is a kidney disease caused by...
Impact of Semaglutide, Liraglutide and Tirzepatide on Cardiometabolic Outcomes: A Comparative Narrative Review.
This review compares three weight-loss and diabetes drugs: semaglutide, liraglutide and tirzepatide. It looks at blood sugar, weight, heart outcomes and some kidney outcomes. It...
Fragility metrics are the wrong tool for finerenone's cardiovascular evidence.
This is a short opinion letter about finerenone, a drug used to protect the heart and kidneys in some people with diabetes and kidney disease. The authors argue that the "fragility...
Multi-omics and machine learning reveal LYZ and ISG15 as diagnostic and therapeutic targets in autoimmune-mediated chronic kidney disease.
Researchers ran computer analyses of gene activity data, including single-cell data, and used machine learning. They were looking for genes that drive kidney disease caused by the...
SGLT2 Inhibitors in Cardiovascular-Kidney-Metabolic Syndrome: Drugs Unifying Heart, Kidney, and Metabolism Pharmacotherapy.
This article reviews what earlier research says about SGLT2 inhibitors. These pills were first made for diabetes and are now used to protect the heart and kidneys. The review...
Association of MASLD with chronic kidney disease according to metabolic profiles and fibrosis severity: a KNHANES analysis.
Using a Korean national health survey, researchers checked whether fatty liver disease linked to metabolism (MASLD) goes along with kidney disease. They also looked at whether...
The CPH-MBD Cohort
This is a new study in Copenhagen that will follow people with kidney disease over time. People with kidney disease are about 3 times as likely to break a bone and 10 times as...
Exploring the mechanism of Yishen Huayu formula in intervening chronic kidney disease-mineral and bone disorder via the miR-340-5p/FGF-23/klotho signaling pathway.
Researchers tested a traditional Chinese herbal mix called Yishen Huayu formula in rats with kidney damage. The rats had the bone and mineral problems that kidney disease can...
Sevelamer carbonate crystal associated colitis in a hemodialysis patient: a case report.
This report describes one 56-year-old man on dialysis whose colon became inflamed from crystals of sevelamer, a common phosphate binder pill. He had diarrhea, vomiting and belly...
The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance
Some people of African ancestry carry APOL1 gene variants that raise their risk of kidney disease a lot. Another small gene change, called M1, is linked to much lower risk in...
SLCO4A1 Governs PGE2-Mediated Natriuresis in the Kidney.
Researchers studied a protein called SLCO4A1 in mice with the gene removed or boosted. The protein controls a natural signal (PGE2) that helps the kidneys flush out salt and water....
Sequential liraglutide and setmelanotide therapy in Bardet-Biedl Syndrome: metabolic and renal outcomes in a real-world case report and literature review.
This report follows one adult with Bardet-Biedl syndrome, a rare genetic condition that causes obesity and kidney disease. The person took liraglutide, a GLP-1 weight-loss drug,...
Associations between serum lactate and renal dysfunction in diabetic kidney disease: An exploratory analysis integrating animal experiments, clinical cohorts, and bioinformatic approaches.
This early study asked whether lactate, a substance in the blood linked to how cells use sugar, is linked to worse kidney function in diabetic kidney disease. It combined animal...
Resident immune cell neighborhoods associate with protein kinase pRIPK3 and fatty acid ligase FACL4 expression during cell injury in ANCA associated vasculitis and lupus nephritis
Researchers studied kidney tissue from people with two autoimmune kidney diseases: ANCA vasculitis and lupus nephritis. They found that clusters of immune cells sat near kidney...
Renal Drug Dosing and Medication Safety in Patients Receiving Dialysis: A Practical Guide for Nephrology Nurses and Advanced Practice Providers.
This is a practical guide for nurses and other care providers on dosing medicines for people on dialysis. Weak kidneys change how the body takes in, uses and clears drugs, so...
Advancing Outpatient Dialysis Safety: Integrating Medication Scanning Technology.
Nurses at outpatient dialysis centers describe adding barcode scanning to check medicines before they are given. The goal is fewer medicine mistakes for people on dialysis, who...
Sick Day Medication Guidance for Adults with Chronic Kidney Disease in Outpatient Settings.
People with kidney disease are more likely than others to be harmed by their own medicines. The risk is highest when they are sick with vomiting, diarrhea, or fever. This review...
Effectiveness of SGLT2 inhibitors in slowing chronic kidney disease progression and reducing mortality: a meta-analysis.
This meta-analysis pooled results from earlier studies to ask whether SGLT2 inhibitors slow kidney disease and help people live longer. SGLT2 inhibitors are a class of drugs first...
eGFR- and Potassium-Guided Stewardship of SGLT2 Inhibitors and Finerenone in Albuminuric Chronic Kidney Disease Associated with Type 2 Diabetes.
This review is about people with type 2 diabetes whose kidney disease leaks protein into the urine. It explains how doctors can safely add an SGLT2 inhibitor and finerenone on top...
Standard of Care for Chronic Kidney Disease: The Four Pillars of Pharmacotherapy - Implications for Nephrology Nursing Practice.
This article for kidney nurses reviews the four main types of medicine now used to slow kidney disease and protect the heart. The four are blood pressure drugs that block the...
Alterations of Gene Expression and Signaling Pathway Activity in Venous Smooth Muscle Cells After Uremic Serum Exposure
Researchers put muscle cells from vein walls into blood serum from people with kidney failure. Serum is the liquid part of blood, and in kidney failure it carries waste the kidneys...
Genome-Wide DNA Methylation Profiling Reveals Stage- and Severity-Associated Epigenetic Alterations in Children with Posterior Urethral Valve-Associated Chronic Kidney Disease
Some boys are born with a blockage in the tube that carries urine out of the body (posterior urethral valves), and it can lead to kidney disease. Researchers looked at chemical...
Hypertension, diabetes, and central obesity as risk factors for chronic kidney disease in class II and III obesity patients
This study looked at people with severe obesity to see which health problems were tied to chronic kidney disease. It focused on high blood pressure, diabetes, and extra fat around...
Efficacy and safety of dupilumab in moderate-to-severe atopic dermatitis with stage 3–5 chronic kidney disease: a retrospective real-world study
This study looked back at the records of people with stage 3 to 5 kidney disease who took dupilumab for moderate to severe eczema. Dupilumab is an injected drug for eczema. The...
Transcriptomics- and machine learning-based identification and mechanistic in vitro validation of a cardiovascular risk gene signature at the CKD–cancer intersection: a multi-omics approach
Researchers used computer analysis of gene activity data to find a group of genes tied to heart risk in people who have both kidney disease and cancer. They then checked some of...
Treatment of Anemia in Chronic Kidney Disease Enters the Era of Personalization
This is an opinion piece in a major medical journal about treating anemia (a low red blood cell count) in chronic kidney disease. It argues that treatment is moving toward being...
Renal pseudocontinuous arterial spin labeling radiomics for early diagnosis and staging of chronic kidney disease
This study tested a type of MRI scan that measures blood flow in the kidneys without any injected dye. Researchers used computer analysis of the images to try to spot chronic...
CONTRAST-INDUCED ACUTE KIDNEY INJURY AS A PREDICTOR OF CHRONIC KIDNEY DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTION: A MULTI-BIOMARKER PROSPECTIVE COHORT STUDY
This study followed people who had a procedure to open blocked heart arteries. The dye used in that procedure can hurt the kidneys suddenly, and the study looked at whether that...
Metabolic phenotype dimensions and longitudinal renal function in type 2 diabetes: a principal component analysis-based approach with UACR integration
A study of 2,100 people with type 2 diabetes found that certain metabolic patterns—like high blood sugar and insulin resistance—were linked to faster decline in kidney filtering...
Effectiveness of SGLT2 inhibitors in slowing chronic kidney disease progression and reducing mortality: a meta-analysis
This meta-analysis of 12 large trials with over 40,000 people showed SGLT2 inhibitors reduced the risk of kidney failure, major heart problems, or death by about 25%. This strong...
Empagliflozin improves serum uric acid and early cardiometabolic outcomes in asymptomatic hyperuricemia among patients with type 2 diabetes : A 6-month observational study
In 120 people with type 2 diabetes and high uric acid but no symptoms, empagliflozin lowered uric acid and improved early heart and metabolism markers over 6 months. This...
Risk of acute kidney injury associated with the albumin–bilirubin score in ICU patients with acute pancreatitis : A cohort study
A study of ICU patients with acute pancreatitis found that a blood test score (albumin–bilirubin) was linked to a higher risk of sudden kidney injury. Because it is observational,...
Gelatin Hydrolysate from Bigeye Snapper (Priacanthus tayenus) Skin Attenuates the Progression of Diabetic Nephropathy in Rats by Modulating Oxidative Stress, Inflammatory Responses, and Endoplasmic Reticulum Stress Signaling Pathways.
In 30 rats with diabetes, a protein from snapper fish skin lowered blood sugar and reduced kidney scarring — but since this was in animals, not people, it is too early to say if it...
Healing or Harming? Navigating Resistance and Rationality in Diabetic Foot Ulcer Antibiotic Therapy: A Retrospective Observational Study.
This study of 200 Indian adults with diabetic foot ulcers found patterns in antibiotic use and infection types — but since it only looked back at records, it shows a link between...
Switching to Angiotensin Receptor-Neprilysin Inhibitor and Reduced Risk of New-Onset Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction: A Nationwide Propensity Score-Matched Study.
In over 39,000 people with heart failure and reduced pumping ability, switching to an ARNI drug was linked to a lower chance of developing atrial fibrillation — but because this is...
GLP-1 receptor agonists, epigenetic aging, and the prospect of pharmacological healthspan extension.
This review discusses how GLP-1 drugs may slow aging of the body’s cells — based on past trials showing fewer heart problems and lower death rates — but it does not report new...
The Incretin Revolution: Integrating Incretin-Based Therapies into Clinical Care.
This narrative review summarizes how GLP-1 drugs and tirzepatide help not just blood sugar but also the heart, kidneys, liver, and breathing — and notes that some now have official...
Prior GLP-1RA or Tirzepatide Use and Early Cardiorenal Outcomes After Metabolic and Bariatric Surgery.
A review of medical records found that people who took GLP-1 drugs or tirzepatide before metabolic surgery had different early heart and kidney outcomes than those who did not —...
Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular-Kidney-Metabolic Syndrome.
This review explains how problems in the nitric oxide pathway may link insulin resistance to kidney decline, based on lab and animal studies — not people yet. It proposes that...
Beyond Weight Loss: Thromboinflammation as a Candidate Mechanism for the Cardiovascular Benefit of GLP-1 Receptor Agonists.
The SELECT trial with 17,604 people who had heart disease but no diabetes found that semaglutide cut serious heart problems like heart attack or stroke by 20% over a few years....
SGLT2 gene expression in thirst-promoting NOS1 neurons and vasopressin-synthesizing neurons in male rats.
In male rats, the kidney drug class SGLT2 inhibitors acted on brain areas that control thirst and fluid balance — helping explain why some people feel thirsty when taking them....
Real-World Utilisation and Cost Trends of Mineralocorticoid Receptor Antagonists in England: A Population-Level Prescribing Analysis From 2022 to 2025.
A look at over two years of NHS prescribing data shows newer kidney-protective drugs (MRAs) are being used more often, and their cost per prescription is rising. Because this only...
High Immunological Activity and the Re-Evaluation of Anti-SSA/SSB Antibodies as Prognostic Markers for Major Organ Damage in Systemic Lupus Erythematosus.
This study of people with lupus found that certain antibodies (anti-SSA/SSB) were linked to worse organ damage over time, especially in Asian patients. Because it only observed...
Cardiac surgery-associated AKI and the risk of progression to end-stage renal disease. A retrospective cohort study.
This study of over 10,000 people who had heart surgery found that those who suffered kidney injury during the operation were much more likely to need dialysis years later. Because...
Ferroptosis as a target mechanism in heart and kidney disease
This review looks at ferroptosis, a type of cell death driven by iron that damages cells in the heart and kidneys. It gathers earlier research on whether blocking this process...
Spatially Distinct TREM2+ Macrophages Are Associated with Compartment-Specific Protection in Diabetic Kidney Disease
In diabetic kidney disease, researchers mapped where a type of immune cell sits inside the kidney. These cells are called TREM2+ macrophages. When they were found in certain parts...
Ibrutinib-Associated Kaposi Sarcoma and Reversible Renal Manifestation in Chronic Lymphocytic Leukemia
This case report describes one person with a blood cancer called chronic lymphocytic leukemia. While taking the cancer drug ibrutinib, they got Kaposi sarcoma, a skin and tissue...
Association of the inflammation indicators with multiple system involved of immunoglobulin A vasculitis in children
This study looked at children with IgA vasculitis, an immune condition that inflames small blood vessels and can damage the kidneys. It checked whether blood tests for inflammation...
Hypokalemia leading to the diagnosis of primary Sjögren’s syndrome: the role of early renal biopsy
This case report describes one patient with low blood potassium (hypokalemia). A kidney biopsy, where a small piece of kidney is taken for testing, led to a diagnosis of Sjögren's...
Update on Perioperative Prevention of Cardiac Surgery-Associated Acute Kidney Injury.
Experts reviewed 14 ways to prevent kidney injury after heart surgery and graded them by study quality; no single method works for everyone because the problem has many causes,...
Effects of intradialytic nutrition on dialysis adequacy and fatigue in hemodialysis patients: a randomized crossover study.
This small trial tested whether eating a standard meal during dialysis changes how tired people feel and how well dialysis cleans the blood. It took place at 2 dialysis centers in...
Effect of Ambient Temperature on Kidney Function.
This review looks at how extreme heat, especially hard work in hot places, harms the kidneys. The authors say heat is a major cause of kidney problems in lower-income regions. It...
Examining the Impact of zinc Deficiency on moderate to severe chronic kidney disease risk and hypertension as an effect Modifier
This study looked at whether low zinc is linked to a higher risk of moderate to severe kidney disease. It also checked whether that link changes in people with high blood pressure....
Essential oil massage and incident chronic kidney disease–associated pruritus in maintenance hemodialysis patients without baseline pruritus: a prospective non-concurrent before-and-after study
This study looked at whether essential oil massage was linked to fewer new cases of itchy skin from kidney disease in hemodialysis patients who did not itch at the start. It...
Trace Element Assessment among Patients with Diabetes Mellitus and Chronic Kidney Disease: A Cross-Sectional Study in Nasarawa State Hospitals, Nigeria
This study measured trace minerals, such as zinc and copper, in the blood of patients with both diabetes and kidney disease at hospitals in Nasarawa State, Nigeria. It took a...
Indoxyl sulfate in the gut–kidney axis: from diet-microbiome interactions to renal injury and targeted therapies
This is a review article about indoxyl sulfate, a waste product made by gut bacteria that builds up when kidneys fail. It covers how diet and gut bacteria affect this waste, how it...
Cognitive Impairment Across the Spectrum of Chronic Kidney Disease: Clinical Characteristics and Implications for Practice—Is There a Role for Medical Nutritional Therapy?
This is a review article. It looks at memory and thinking problems in people at every stage of chronic kidney disease. It asks whether diet therapy guided by a clinician could...
Fucus vesiculosus-Derived Fucoidan Mitigates Recognition Memory Deficits in Association with Modulation of the Microbiota–Gut–Brain Axis in Adenine-Induced Chronic Kidney Disease Mice
Researchers gave fucoidan, a substance from a brown seaweed called bladderwrack, to mice with kidney disease caused by a chemical. The mice had memory problems, and the extract...
Determinants of Symptom Burden in Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Cohort Study
This study looked at what goes along with a heavy load of symptoms, like tiredness, itching and poor sleep, in people with kidney disease who are not on dialysis. It took one...
Dietary patterns and physical activity in relation to renal and metabolic outcomes among older adults with type 2 diabetes and chronic kidney disease: a systematic review
This systematic review (a structured summary of many earlier studies) looks at how eating patterns and exercise relate to kidney and blood sugar outcomes. It focused on older...
Prospective Analysis of Self Medication With Phytotherapy in Nephropatic Patients.
This is a planned study on Réunion island, run through kidney clinics, that will survey people with kidney disease about taking herbal remedies on their own. It will ask how common...
Occupational heat exposure, nighttime warming, and eGFR loss in petrochemical workers: a retrospective cohort study with metabolomic evidence.
This study followed 2,148 petrochemical workers in southeastern China from 2013 to 2022. It asked whether heat on the job, and warmer nights, were tied to a big drop in kidney...
Kidney Risks Linked to Per- and Polyfluoroalkyl Substance Exposure.
This review pulls together research on PFAS, the long-lasting 'forever chemicals' found in some drinking water, food packaging, dust, fabrics and firefighting foam. It looks at how...
Mineral Supplement Use in Patients with Chronic Kidney Disease: What Nephrology Nurses Need to Know.
This review for nurses covers four minerals often taken as supplements and how they affect people with weak kidney function. Advice on how much to take is usually based on people...
Serum N-terminal pro-B-type natriuretic peptide and physical performance in middle-aged and older patients with chronic kidney disease.
Researchers looked at middle-aged and older people with kidney disease who were not on dialysis. They checked whether weaker physical performance, such as strength and walking...
Glow-food illuminating nutritional value and enhancing taste in chronic kidney disease: a Mediterranean perspective.
This review looks at how to make kidney-friendly food healthy and also tasty, using a Mediterranean-style way of eating. The authors point to earlier research linking Mediterranean...
8 Kidney-Friendly Recipes to Celebrate Hispanic Heritage Month
The National Kidney Foundation shared eight Hispanic dishes, like pasteles and fresh salsa, adjusted to be easier on the kidneys. It is a recipe collection, not a study, so it has...
Surface water quality and chronic kidney disease burden in China, Canada, and Ireland: an exploratory ecological panel study
This study compared river and lake water quality with how common chronic kidney disease is in China, Canada, and Ireland over time. It looked at whole populations, not individual...
Nutrition and Green Nephrology - not only for health but also for compensation: the water footprint and its hamburger equivalent
This is a discussion piece about food choices in kidney care and how much water it takes to produce them. It compares that water use to the water behind one hamburger. It is about...
Effects of Exercise Training on Experimental Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
This review of animal studies found that exercise improved kidney and muscle health in rats with kidney disease — but since no people were studied, it is not yet known if these...
Sex Modifies the Association Between Planetary Health Diet Adherence and Kidney Function Decline in US Adults Aged 50 Years and Older.
In over 2,100 adults aged 50 and older, higher adherence to a planetary health diet was linked to slower kidney function decline — but because this is an observational study, it...
Dietary iron imbalance disrupts enterohepatic homeostasis via the gut microbiota-bile acid-FXR signaling axis.
In people and mice, eating too much iron (especially from supplements) was linked to diarrhea, liver stress, and changes in gut bacteria — all of which may worsen kidney health...
Physical Exercise in Patients With Chronic Kidney Disease in Hemodialysis (Pehedal-ESKD)
This is a new study that is starting, and it has no results yet. Adults on regular dialysis will exercise during their sessions. Some will use a stationary bike and some will use...
The Mapping of Meditation-Based Interventions with Emphasis on Brain-Derived Neurotrophic Factor in Hypertension: A Scoping Review.
This review searched 5 research databases for studies of meditation in people with high blood pressure. It also looked at BDNF, a growth protein in the brain that may play a part...
Psychological Distress and Predictors of Anxiety and Depression in New Hemodialysis Patients.
This study measured anxiety and depression in people who had just started dialysis, the treatment that filters blood when the kidneys fail. It also looked for traits linked to more...
Altered microstructure in end-stage renal disease patients with maintenance hemodialysis: A diffusion kurtosis imaging analysis.
People with end-stage kidney disease and cognitive problems had different brain scan patterns than those without problems or healthy volunteers. This study shows a link between...
Early-Life Stress Programs a Vulnerable Renal Phenotype Under Metabolic Challenge in a Murine Model
Baby mice exposed to early stress developed kidneys more likely to get damaged when fed a high-sugar diet later. This was in animals only — it does not tell us what happens in...
Dedifferentiated proximal tubular epithelial cells in diabetic kidney disease: pathogenic roles, repair potential, and therapeutic implications
This review looks at kidney filter cells in diabetic kidney disease that lose their normal job and change shape. It covers how these cells may add to damage, and how they might...
Combined Mesenchymal Stem Cells and Low-Energy Shock Wave Therapy Significantly Reduced Inflammation, Oxidative Stress and Preserved Podocytes in Diabetic Nephropathy
Researchers combined stem cells from support tissue with gentle shock wave therapy to treat kidney damage caused by diabetes. They report less swelling and less cell damage, and...
Extracellular vesicles mediate immune regulation in acute kidney injury.
This review looks at extracellular vesicles, tiny bubbles that cells release to send proteins and genetic messages to other cells. It covers how they may steer swelling and repair...
A randomized cross-over trial of pre-and post-filter hemodiafiltration modalities in children on maintenance dialysis -- effects on solute removal and blood pressure
Children on long-term dialysis tried two versions of hemodiafiltration, a dialysis method that pulls extra fluid through the filter to clear more waste. Each child had both...
Predictors of Primary Arteriovenous Fistula Failure in Patients With End-Stage Renal Disease: A Single-Centre Retrospective Cohort.
An arteriovenous fistula (AVF) is a joined artery and vein in the arm, made by surgery so a person can have dialysis. This study looked back at 151 fistulas in 125 adults at one...
Epigenetic strategies for mitigating kidney fibrosis
This review covers ways to reduce kidney scarring (fibrosis) by changing epigenetics, the chemical switches that turn genes on and off. Most research on this so far has been done...
Functional Nanostructured Carbon Honeycomb Monoliths for Hemoadsorption: Preliminary Studies on Biocompatibility, Protein-Bound Uremic Toxins and Inflammatory Cytokines Elimination.
This study tested a new carbon filter made from rice husks to remove toxins and inflammation-causing substances from blood in the test tube and animals. It is not yet tested in...
Immune cell dynamics during compensatory renal hypertrophy after unilateral nephrectomy
In mice that had one kidney removed, scientists tracked immune cell changes as the remaining kidney grew larger. This happened in animals only — it does not tell us what happens in...
Light-activated CRISPR/dCas9 nanomedicine for programmable control of renal fibrosis.
Scientists created a light-activated gene tool in the test tube and in mice that can turn off scarring signals in the kidney. This is very early work — no humans have been treated...
Elevated Prorenin Induces Podocyte Injury and Glomerular Fibrosis in cyp1a1-Prorenin Transgenic Rats.
In rats, high levels of a protein called prorenin damaged the kidney’s filtering cells and caused scarring — findings that may help explain why some people with diabetes lose...
From fundus to filtration: AI-driven retinal phenotyping as a framework for non-invasive prediction of kidney pathological categories (the “virtual renal biopsy” concept)– a narrative review
This review describes an idea called a "virtual kidney biopsy." Computer programs (artificial intelligence) would read photos of the back of the eye to guess what kind of kidney...
Renal Outcomes Following Autologous Stem Cell Transplantation in Dialysis-Dependent Patients With Multiple Myeloma: A Single-Center Study From a Low- and Middle-Income Country.
Five dialysis-dependent patients with blood cancer received stem cell therapy; four recovered some kidney function and stopped dialysis, while one died. The study was small — just...
Apixaban Use Before Kidney Transplantation: Is Reversal Necessary?
This paper asks whether people taking the blood thinner apixaban (Eliquis) need a drug to undo it before getting a kidney transplant. No abstract was available, so we cannot report...
Spatiotemporal patterns of kidney transplantation, chronic kidney disease, and traumatic brain injury mortality in Brazil
This study mapped patterns over time and across regions of Brazil for kidney transplants, deaths from chronic kidney disease, and deaths from traumatic brain injury. It is...
Factors Associated With Willingness to Support Organ Donation in Trinidad and Tobago
This study asked people in Trinidad and Tobago what makes them more or less willing to support organ donation. More donors would mean more kidneys for transplant. A survey like...
Fabry Disease Screening in Kidney Transplant Recipients: A Single-Center Retrospective Study
One hospital looked back through its records to see how often kidney transplant patients turned out to have Fabry disease. Fabry disease is a rare inherited condition that can...
Urine inflammatory protein levels decrease following kidney transplantation.
Researchers measured signs of inflammation in the urine of 10 kidney transplant recipients and their 10 donors, starting about a week before surgery. The levels of these...
Immunosuppressant and Prophylactic Medications in Patients with a Kidney Transplant.
This review for nurses covers the medicines kidney transplant patients take to keep their body from rejecting the new kidney. It also covers the medicines they take to prevent...
The Role of Baseline Systemic Inflammatory Indices Predicting Long-Term Mortality in Kidney Transplant Recipients.
In 353 kidney transplant recipients, higher levels of certain blood markers linked to inflammation were tied to a greater risk of dying over the long term. This study shows a...
Long-Term Kidney Graft Survival: A Paired Analysis of Contralateral Kidney Transplants From the Same Donors.
This study followed 208 people who received kidney transplants and found that some factors helped one kidney from a donor last longer than the other kidney from the same donor....
Everolimus-Involving Immunosuppression Attenuates Renal Interstitial Fibrosis Through Modulation of Mammalian Target of Rapamycin-Related Signal Transduction.
Among 104 kidney transplant patients, those who took everolimus (a drug that blocks a specific immune signal) had less kidney scarring over time than those on older drugs. The...
Navigating the Emotional Landscape of Kidney Allograft Failure
This journal piece discusses the emotional side of losing a transplanted kidney: the grief, fear and stress that can come when a transplant stops working. It is a discussion piece,...
Hemodialysis professionals' knowledge, attitudes, and practices toward venous thrombosis prevention: a multicenter survey.
This survey asked dialysis staff at several centers what they know, believe, and do about preventing blood clots in the veins. These clots are a serious risk for people on...
Making Modern Diabetes Medications Affordable and Accessible: Lessons From India for Other Countries.
This article looks at how India lowered the price of newer diabetes drugs, including SGLT2 inhibitors and GLP-1 drugs. These drugs help protect the heart and kidneys, but cost...
Addressing Women’s Gynaecological and Reproductive Health in Nephrology: Gaps in Confidence, Training, and Service Delivery from a UK National Survey
This UK national survey asked kidney care staff how well they handle women's gynecological and reproductive health (periods, pregnancy, fertility, menopause). It reports gaps in...
World Kidney Day 2026 in Africa: bridging environmental sustainability with the realities of kidney care
This is a commentary for World Kidney Day 2026. It discusses how kidney care in Africa can be made better for the environment, given real limits on money and resources. It reports...
Climate-associated burden of chronic kidney disease due to non-optimal temperature in G20 countries: evidence from a multicountry longitudinal study
This study tracked chronic kidney disease across the G20 countries over time. It looked at how much of that disease is linked to temperatures that are too hot or too cold. This...
The prediction of all-cause mortality in end-stage kidney disease patients using social determinants of health: A machine learning framework.
Researchers built a computer model to predict which people with kidney failure (end-stage kidney disease, when the kidneys can no longer work on their own) will die during...
Uprooting inequity: cultivating a flourishing and socially accountable nephrologist workforce for Indigenous peoples
Indigenous people in New Zealand, Australia and the USA get kidney disease far more often, but very few kidney doctors come from their communities. This article argues that the...
Gastrointestinal Bleeding Is Associated with Worse In-Hospital Outcomes in Patients with ST-Segment Elevation Myocardial Infarction: An Analysis of the National Inpatient Sample
A large hospital database analysis found that patients who had bleeding in the stomach or intestines during a heart attack were more likely to stay longer in the hospital. This...
Prevalence of Bone Mineral Disorders in Hemodialysis Patients: A Prospective Observational Study from a Tertiary Care Hospital in South India
A prospective study of 312 hemodialysis patients found that nearly half had abnormal bone mineral levels — but because it only followed people over time without comparing groups,...
Higher serum sodium-to-chloride ratio identifies near-term mortality risk in adults with confirmed chronic kidney disease: a retrospective landmark cohort study
A retrospective study of 12,450 adults with chronic kidney disease found that a higher sodium-to-chloride ratio in blood was linked to a greater risk of dying within 30 days — but...
Annual Data for Spoken Language Preferences of End-Stage Renal Disease (ESRD) Medicare Initial Claims - FY 2023 On
This is a yearly Medicare data set, starting in fiscal year 2023. It shows which spoken languages people with kidney failure prefer when they first file Medicare claims. It is raw...
Evaluation and Management of Anemia in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2026 Clinical Practice Guideline
Kidney disease experts updated their 2026 guidelines on treating anemia in chronic kidney disease, based on the best available evidence from large studies and trials.
Opisthorchis viverrini infection is associated with kidney injury involving excretory–secretory product-mediated inflammation, oxidative stress, and hypoxia
A study in people found that a parasite infection linked to liver disease also raises the risk of kidney injury, but because it only observed people over time, it cannot prove the...
: Increasing awareness of nonuremic calciphylaxis: clinical manifestations, comorbidities and treatment outcomes in a retrospective single-center cohort
A回顾性研究 looked at 108 people with a rare complication after kidney disease, finding links to calcium problems and high death rates, but because it only looked back at past records,...