← brief for 2026-09-16 · Transplant & xeno

Everolimus-Involving Immunosuppression Attenuates Renal Interstitial Fibrosis Through Modulation of Mammalian Target of Rapamycin-Related Signal Transduction.

Key takeaways

Among 104 kidney transplant patients, those who took everolimus (a drug that blocks a specific immune signal) had less kidney scarring over time than those on older drugs. The study was small and not randomized, so it shows a possible benefit but needs confirmation in larger trials.

Who did this work

Saito T · Saito M · Yamamoto R · Sagehashi R · Aoyama Y · Mori M · Kajiwara C · Furihata K · Kagaya H · Yagishita H · Fujiyama N · Kashima S

Source

Article · PubMed, fibrosis reversal · 2026 Aug 26
https://pubmed.ncbi.nlm.nih.gov/42737533/