← brief for 2026-09-16 · Nutrition & lifestyle

Dietary iron imbalance disrupts enterohepatic homeostasis via the gut microbiota-bile acid-FXR signaling axis.

Key takeaways

In people and mice, eating too much iron (especially from supplements) was linked to diarrhea, liver stress, and changes in gut bacteria — all of which may worsen kidney health over time. Because the study only observed links and did not change diets randomly, it does not prove iron causes harm.

Who did this work

Zhou H · Wu T · Fan Z · Shi Y · Wang F · He J · Da Y · Lin J · Zhang J · Liang J

Source

Article · PubMed, organoids & devices · 2026 Sep 14
https://pubmed.ncbi.nlm.nih.gov/42735796/