← brief for 2026-09-16 · Slowing decline

Switching to Angiotensin Receptor-Neprilysin Inhibitor and Reduced Risk of New-Onset Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction: A Nationwide Propensity Score-Matched Study.

Key takeaways

In over 39,000 people with heart failure and reduced pumping ability, switching to an ARNI drug was linked to a lower chance of developing atrial fibrillation — but because this is an observational study, it shows association only, not proof that the drug caused the benefit.

Who did this work

Park YJ · Cho DH · Choi J · Youn JC · Kim MN · Lee CJ · Son JW · Yoo BS

Source

Article · PubMed, Losartan and CKD, long-term use · 2026 Sep 15
https://pubmed.ncbi.nlm.nih.gov/42740677/