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SGLT2 gene expression in thirst-promoting NOS1 neurons and vasopressin-synthesizing neurons in male rats.

Article D Peer reviewed Preclinical

Key takeaways

In male rats, the kidney drug class SGLT2 inhibitors acted on brain areas that control thirst and fluid balance — helping explain why some people feel thirsty when taking them. Because this was done only in rats, it is not yet known if the same happens in humans.

Who did this work

Masuda T · Yoshida M · Kim YC · Vallon V · Morishita Y · Nagata D · Onaka T

Source

Article · PubMed, the drug frontier · 2026 Sep
https://pubmed.ncbi.nlm.nih.gov/42740470/