← brief for 2026-09-16 · Slowing decline

Genome-Wide DNA Methylation Profiling Reveals Stage- and Severity-Associated Epigenetic Alterations in Children with Posterior Urethral Valve-Associated Chronic Kidney Disease

Key takeaways

Some boys are born with a blockage in the tube that carries urine out of the body (posterior urethral valves), and it can lead to kidney disease. Researchers looked at chemical tags on these children's DNA that switch genes on or off. They found patterns that differed with how advanced and how severe the kidney disease was. This shows a link, not proof of cause, and the number of children was not in the text we had.

Who did this work

Sachit Anand (All India Institute of Medical Sciences) · Catherine Daise Arokiadas (All India Institute of Medical Sciences) · Ajay Verma (All India Institute of Medical Sciences) · Jitendra Kumar Meena (All India Institute of Medical Sciences) · Chittaranjan Behera (All India Institute of Medical Sciences) · Sandeep Agarwala (All India Institute of Medical Sciences) · Kalpana Luthra (All India Institute of Medical Sciences)

Source

Paper · OpenAlex, CKD works · 2026-09-13
https://doi.org/10.3390/epigenomes10030058