Kidney research, 2026-09-01
No new human studies today, just early lab work worth watching
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Nothing published today changes how stage 3 kidney disease is treated or managed.
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Two lab studies are at a very early stage, one growing kidney tube cells to test whether drugs harm them and one looking at stiff, hardened arteries in mice.
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A journal review pulled together how the kidney's own DNA and RNA alarm systems can drive inflammation, which is background science rather than advice you can act on.
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Days like this are normal, and the steady basics still matter more than any single day of headlines.
Today's sweep turned up no studies in people, so there is nothing here that should change your care plan or your questions for your next appointment. The three items that did come in are early science: cell and mouse work, plus a review article explaining how kidney inflammation may get switched on. That kind of work can take years to lead anywhere, and most of it never reaches patients. We flag it so you can see the direction research is heading, not because it asks anything of you now.
Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus
Many people on dialysis get severe itchy skin, which is hard to live with. Difelikefalin is a drug that has already been shown to reduce that itching in adults on dialysis. This...
[Clinical and functional characteristics of Parkinson's disease in patients with chronic kidney disease].
Researchers compared 62 people with early to middle stage Parkinson's disease. Half of them, 31 people, also had moderate kidney disease, with a kidney filtering rate (eGFR) of 30...
Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal disease.
Scientists looked at chemical tags on DNA, called methylation, which switch genes on and off without changing the genes themselves. They compared 1,031 people with kidney failure...
Aloin attenuates high-glucose-induced oxidative and inflammatory damage in renal cells via AMPK/Nrf2 signaling.
Aloin is a natural compound found in aloe plants. Researchers grew kidney filtering tube cells in high sugar to copy the damage diabetes does, then treated them with aloin. Aloin...
Successful Control of Late-Onset Nephrotic Syndrome in FN1-Associated Fibronectin Glomerulopathy: A 17-Year Clinical Course.
Fibronectin glomerulopathy is a rare kidney disease where a protein called fibronectin builds up and clogs the kidney's filters. Doctors report one 26-year-old woman with a change...
Renal Denervation: A Multicenter, Real-World Experience
Renal denervation is a procedure that burns tiny nerves in the arteries feeding the kidneys, to lower blood pressure. Several hospitals pooled their everyday results with it and...
A case report of WT1-associated infantile steroid-resistant nephrotic syndrome with atypical genotype–phenotype correlation
This is a report on a single infant with nephrotic syndrome, a condition where the kidneys leak large amounts of protein into the urine, caused by a change in the WT1 gene....
Perfil cardiovascular e alterações ecocardiográficas em pacientes com doença renal crônica em hemodiálise: estudo observacional no Sul do Maranhão
Doctors in southern Maranhão, Brazil used heart ultrasound scans (echocardiograms) to look at the hearts of people on dialysis. They report how common heart changes are in this...
Retrospective analysis of the effects of peritoneal dialysis modes, initial doses, and frequencies on residual renal function and quality of life in patients initiating peritoneal dialysis
Doctors looked back at the records of people starting peritoneal dialysis, the kind done through the belly rather than by machine. They compared different modes, starting doses,...
EP05.88: A prenatal ultrasound‐based prototype calculator for predicting childhood renal impairment in fetuses with CAKUT
Researchers built a prototype calculator that uses a pregnancy ultrasound to predict whether a baby born with a kidney or urinary tract defect (called CAKUT) will have poor kidney...
UMOD gene variants in autosomal dominant tubulointerstitial kidney disease: first cases reported from Türkiye
This is the first report from Türkiye of families with an inherited kidney disease caused by changes in a gene called UMOD. The disease, known as ADTKD, slowly scars the kidneys...
Association between lactate-to-albumin ratio and 28-day all-cause mortality in critically ill patients with chronic kidney disease: A retrospective cohort study from the Medical Information Mart for Intensive Care IV database.
In 4,271 seriously ill people with chronic kidney disease in intensive care, researchers tested whether one blood measure predicted death within 28 days. The measure is the ratio...
Assessment of NGAL, eGFR, and tubular injury markers for early detection of chemotherapy-induced nephrotoxicity in pediatric oncology patients
Doctors checked whether blood and urine markers can catch kidney damage from cancer drugs early in children being treated for cancer. They compared NGAL, a protein that rises when...
Correlation of Ultrasonographic Parameters with Serum Creatinine in Patients with Chronic Kidney Disease
This study compared what kidneys look like on ultrasound with creatinine, the waste product in blood used to judge how well kidneys filter. The idea is that imaging measures like...
Cryoglobulinemia-associated kidney disease: long-term insights into pathology, outcomes, and prognostic factors
This report followed people with kidney disease caused by cryoglobulinemia, a condition where abnormal proteins clump in the blood when it cools and damage small blood vessels,...
Achieved systolic blood pressure and cardiovascular outcomes in advanced chronic kidney disease
This study looked at people with advanced kidney disease and asked which achieved top blood pressure number went with the fewest heart attacks, strokes and heart deaths. Blood...
ANALYSIS OF STUDIES ON RISK FACTORS CONTRIBUTING TO THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN ADOLESCENTS
This is a review of earlier studies on what raises the risk of chronic kidney disease in teenagers. It gathers findings from other people's observational work rather than running a...
Assessment of Potential Drug Interactions in Patients With Chronic Kidney Disease Undergoing Hemodialysis
Researchers reviewed the medicine lists of people on dialysis and counted how often two drugs could clash with each other. People with kidney failure take many drugs at once, and...
Effect of kidney function on drug concentrations of first-line anti-tubercular treatment
This study measured how much tuberculosis medicine ended up in the blood of patients with different levels of kidney function. Weak kidneys clear drugs more slowly, which can push...
Risk of Urinary Tract Infections in Diabetic Patients Taking Sodium Glucose Inhibitors
This study looked at how often people with diabetes taking SGLT2 inhibitors got urinary tract infections. SGLT2 inhibitors are the kidney protecting drugs that make you pass sugar...
Long-term cardiorenal illness trajectories after initiation of antihypertensive medications in adults with and without ADHD: a nationwide cohort study
Researchers used national health records to follow adults who started blood pressure medicine, comparing those with ADHD to those without, and tracked heart and kidney illness over...
COMBINING SGLT2 INHIBITORS AND FINERENONE IN CARDIOVASCULAR-KIDNEY-METABOLIC (CKM) SYNDROME: A CLINICAL UPDATE
This is a clinical update on using two kidney protection drugs together: SGLT2 inhibitors, which make the kidneys pass extra sugar out in the urine, and finerenone, which blocks a...
Touraine–Solente–Golé Syndrome (Primary Hypertrophic Osteoarthropathy) Presenting With Chronic Kidney Disease: A Rare Case Report
A report on a single patient with a very rare bone and skin syndrome who also had chronic kidney disease. One case cannot show that the syndrome caused the kidney damage, and it...
A Comparative Study on the Value of Blood Cellular Indices in Predicting the Outcomes in End Stage Renal Disease.
Researchers compared 11 cheap measures taken from a routine blood count to see which best predicts how people with end stage kidney disease will do. End stage means less than 15%...
Uric acid as a biomarker in patients with COPD and CKD.
Uric acid is a waste product that healthy kidneys clear from the blood. This study looked at uric acid levels in people who have both lung disease (COPD) and chronic kidney...
Incretin-Based Therapies Versus Bariatric and Metabolic Surgery for Obesity and Type 2 Diabetes Mellitus: A Head-to-Head Systematic Review of Glycaemic, Cardiovascular, Hepatic, Weight, and Quality-of-Life Outcomes.
A systematic review comparing GLP-1 weight loss drugs against weight loss surgery for obesity and type 2 diabetes. It measured blood sugar, heart, liver, weight and quality of life...
Adverse pregnancy outcomes and long-term cardiovascular risk: lifelong connections.
A review arguing that problems during pregnancy, such as high blood pressure or gestational diabetes, are early warning signs of heart and metabolic disease decades later. It is...
Anticoagulation in Advanced Chronic Kidney Disease: Navigating Uncertainty.
Advanced kidney disease raises the risk of dangerous blood clots and dangerous bleeding at the same time, which makes blood thinners a hard call. This review covers people with...
Long-term outcome of pediatric anti-complement factor H antibody-associated atypical hemolytic uremic syndrome receiving abbreviated plasma exchange: a retrospective study from a single center.
Children under 12 with a rare disease that clots the small blood vessels in the kidneys (atypical hemolytic uremic syndrome, caused by an antibody against a blood protein called...
The Association Between NT-Pro BNP, Nephropathy and Endothelial Dysfunction in Patients With Type 2 Diabetes Mellitus.
This study measured a heart blood test called NT-proBNP in people with type 2 diabetes who had no known heart failure. It checked whether higher levels went along with kidney...
Nephropathies Associated with Sickle Cell Trait and How to Study Them.
People with sickle cell trait — just one copy of the gene, not full disease — may have worse kidney filtering rate over time and more protein in their urine, based on studies of...
Soluble CD163 as a Non-Invasive Biomarker in Autoimmune Nephrological and Rheumatological Diseases.
A review of studies found that a blood or urine test for soluble CD163 — a sign of immune cell activity — may help track inflammation in autoimmune diseases that affect the...
Nucleic acid sensing pathways in kidney disease development
This is a review of past work, not a new study. Cells have alarm systems that spot stray bits of DNA and RNA, and the authors describe how those alarms can switch on inflammation...
Arterial Elastin Abundance, Rather Than Orthologue Origin, Modulates Medial Arterial Calcification in Matrix Gla Protein-Deficient Mice
Calcium can build up in the walls of arteries and stiffen them, which is common in kidney disease and diabetes. Working in mice that lack a protein which normally blocks that...
Ambient PM <sub>2.5</sub> Concentration and the Cardiovascular Response to Exercise Training: A Systematic Review and Meta-Analysis Across Global Pollution Gradients
This review looked at many studies from around the world and found that high air pollution (PM2.5) reduces how much exercise helps the heart — people in dirty-air areas saw about...
Dual Antioxidant Supplementation With N-Acetylcysteine and Taurine (Nefrosave ® ) for Cardio-Renal Protection in Chronic Kidney Disease Patients With Diabetes and/or Hypertension: A Real-World, Retrospective, Comparative Study
Researchers looked back at charts of people with kidney disease plus diabetes or high blood pressure who took a branded supplement combining two antioxidants, N-acetylcysteine and...
Effect of Probiotic Supplementation on Azotemia and Proteinuria in Patients with Diabetic Kidney Disease: A Randomized Controlled Trial
This was a randomized trial of probiotics, the live bacteria found in supplements and yogurt, in people whose kidneys were damaged by diabetes. It measured waste products building...
Associations of life’s crucial 9 and its components with all-cause and cardiovascular mortality in diabetic kidney disease patients
Researchers scored people who have kidney damage from diabetes on a 9-part heart-health checklist called Life's Crucial 9. The nine parts are diet, exercise, sleep, smoking,...
Sodium-containing medications and laxative use among older primary care patients requiring sodium restriction: findings from the LAXAP study
The LAXAP study counted how often older primary care patients who are told to cut back on salt are given medicines and laxatives that contain sodium anyway. This matters because...
Severe heat stress exposure as a hidden driver of future cardiovascular disease: a narrative review of animal and human studies.
A review of animal and human work suggesting severe heat stress may cause lasting heart damage, especially during hard physical work. It focuses on heart outcomes and reports no...
Prevalence and Pattern of Chronic Kidney Disease-Associated Pruritus in a Nigerian Teaching Hospital.
Doctors at one teaching hospital in southern Nigeria counted how many people with chronic kidney disease had itchy skin, and what kind of itching they had. Itching is common in...
THE EFFECT OF MEDITATION SUPPORT ON STRESS LEVELS AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS
This study gave meditation support to people with chronic kidney disease who were on dialysis and measured their stress levels. Stress scores were reported as lower after the...
A Long-Term Follow-Up Study of Participants Exposed to REACT
REACT is a treatment that takes a person's own kidney cells, grows them, and injects them back into that same kidney through the skin. People in this study got up to two...
The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin
Researchers tested stem cells taken from placenta to see if they protect kidneys in long-term kidney failure, and looked at adiponectin, a hormone made by fat tissue that lowers...
The Relationship Between the Duration of Cimino Arteriovenous Fistula Use and Quality of Life Among Hemodialysis Patients
Researchers asked whether people on dialysis report a better quality of life the longer their Cimino fistula has been working. A fistula is a surgical join between an artery and a...
Advanced nanocatalytic medicine for genitourinary diseases: Reactive oxygen modulation, precision therapeutics, and clinical translation.
A review of tiny engineered particles, called nanocatalysts, being designed to treat kidney and urinary diseases. They are built to react to conditions found in damaged tissue,...
New Dimensions in Diabetic Kidney Disease Research: Advanced Organoids and Organs-on-a-Chip.
A review of two newer lab models for studying kidney disease caused by diabetes: organoids, which are tiny clumps of lab grown kidney tissue, and organ on a chip devices, which...
Heat shock protein 70 protects against peroxynitrite-induced inactivation of the cardiac sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a).
In test-tube experiments with human kidney cells, a protein called Hsp70 helped protect another protein that moves calcium in and out of cells — a process important for healthy...
Scalable proxiloids enable human-relevant assessment of kidney proximal tubule toxicity
Researchers built "proxiloids", small lab-grown copies of the kidney tubes that reabsorb fluid and handle drugs. Those tubes are a common site of drug damage and sudden kidney...
Effects of dapagliflozin on proteinuria, glycemic control, and treatment burden in diabetic kidney transplant recipients: a matched cohort study.
Dapagliflozin is an SGLT2 inhibitor, a diabetes drug that also protects kidneys in people with chronic kidney disease. Doctors compared kidney transplant recipients with diabetes...
Kidney transplantation in older people (KTOP): a longitudinal, qualitative study of kidney transplant experiences in older, frail adults
Researchers interviewed older, frail adults over time about what getting a kidney transplant was actually like for them. This is an interview study, so it captures experience and...
Kidney Transplant in Brazil During the Peripandemic Period: Finally, Have we Recovered?
Kidney transplant numbers in Brazil dropped sharply during the pandemic, and this report asks whether the country's program has caught back up. It counts transplants over time...
Protective Effects of Quercetin and Sucrose on Cold Preservation Injury in Porcine Kidneys Donated After Cardiac Death.
Researchers added quercetin, an antioxidant found in fruit and vegetables, plus sucrose (table sugar) to the cold fluid used to store donated kidneys. They tested it in pig kidneys...
[Advanced chronic kidney disease and end-stage kidney disease in Latin America: Gaps in continuity of care, the strategic role of kidney transplantation, and challenges for health governanceDoença renal crônica avançada e terminal na América Latina: lacunas no continuum de cuidados, papel estratégico do transplante renal e desafios para a governança em saúde].
This is a report on the state of advanced and end-stage kidney disease across Latin America. It describes where care breaks down: kidney disease is caught late, people are not...
Acute peritoneal dialysis adequacy among children at a national referral hospital in Kenya: a cross-sectional study in a resource-limited setting
Doctors at Kenya's national referral hospital checked whether children getting emergency peritoneal dialysis, which cleans the blood using fluid in the belly, actually got enough...
Examining factors associated with catheter-defined unplanned dialysis initiation: a UK renal registry analysis
Many people start dialysis as an emergency, through a tube in a neck or chest vein, instead of with a planned access made in advance. This study searched the UK's national kidney...
Influence of Educational Campaigns on Community Knowledge About Chronic Kidney Disease: Results from a Community-Based Campaign
A community campaign tried to teach the public about chronic kidney disease, then measured what people knew afterward. Knowledge went up, but this was a before and after survey,...
DEBUNKING TEN MYTHS ABOUT KIDNEY SUPPORTIVE CARE
This is an opinion piece that takes on ten common myths about kidney supportive care, the kind of care focused on comfort, symptoms, and choices rather than on cure. It argues that...