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Effect of kidney function on drug concentrations of first-line anti-tubercular treatment

Key takeaways

This study measured how much tuberculosis medicine ended up in the blood of patients with different levels of kidney function. Weak kidneys clear drugs more slowly, which can push drug levels too high or too low. It is an observational drug level study, so it shows a link between kidney function and drug levels, not proof of cause. It matters for anyone with kidney disease who needs TB treatment, because the dose may need adjusting.

Who did this work

Divya Datta (Manipal Academy of Higher Education) · Indu Ramachandra Rao (Manipal Academy of Higher Education) · Raghavendra Shetty (Navitas Life Sciences (India)) · Shankar Prasad Nagaraju (Manipal Academy of Higher Education) · Girish Thunga (Manipal Academy of Higher Education) · Rahul Magazine (Manipal Academy of Higher Education) · Shivashankara Kaniyoor Nagri (Manipal Academy of Higher Education) · Nisha Abdul Khader (Manipal Academy of Higher Education) · Pasumarthi Tejashree (Manipal Academy of Higher Education) · Surulivelrajan Mallayasamy (Manipal Academy of Higher Education) · Praveen Kumar Tirlangi (Manipal Academy of Higher Education) · Dharshan Rangaswamy (Manipal Academy of Higher Education)

Source

Paper · OpenAlex, CKD works · 2026-08-31
https://doi.org/10.1007/s15010-026-02931-7