← brief for 2026-09-01 · Slowing decline

Association between lactate-to-albumin ratio and 28-day all-cause mortality in critically ill patients with chronic kidney disease: A retrospective cohort study from the Medical Information Mart for Intensive Care IV database.

Key takeaways

In 4,271 seriously ill people with chronic kidney disease in intensive care, researchers tested whether one blood measure predicted death within 28 days. The measure is the ratio of lactate to albumin: lactate rises when tissues are short of oxygen, and albumin is a blood protein that drops when someone is very sick or poorly nourished. This is a look back at records from a single hospital database, so it shows a link, not cause. It is a warning sign doctors can watch, not a treatment.

Who did this work

Chen L · Lv C · Ni H · Hu X · Cheng X

Source

Article · PubMed, CKD severity and reversal · 2026 Aug 31
https://pubmed.ncbi.nlm.nih.gov/42676012/