← brief for 2026-09-01 · Regeneration & devices

Scalable proxiloids enable human-relevant assessment of kidney proximal tubule toxicity

Key takeaways

Researchers built "proxiloids", small lab-grown copies of the kidney tubes that reabsorb fluid and handle drugs. Those tubes are a common site of drug damage and sudden kidney injury, and current lab models either miss how the tubes really work or cannot be made in large enough numbers. The team says this version can be made at scale for drug safety testing. This was done in lab-grown cells, not in people, and it is a preprint that has not been peer reviewed.

Source

Preprint · bioRxiv cell biology (kidney-filtered downstream) · 2026-09-01
https://www.biorxiv.org/content/10.64898/2026.08.31.748260v1?rss=1