Kidney research, 2026-09-30
A new diabetes drug proved safe for the heart in a large trial.
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A small study found that a specific gene is more active in people with kidney disease, but more research is needed.
The strongest news today is that a new diabetes drug is safe for the heart. This matters because heart health helps protect the kidneys. Other studies looked at air pollution and genes, but they are not strong enough to change your care yet.
Analysis of end-stage renal disease mediated by cuproptosis-related genes.
This study looked at genes related to a type of cell death called cuproptosis. It checked if these genes are different in people with end-stage kidney disease. The results showed...
Prognostic value of neutrophil percentage-to-albumin, uric acid-to-creatinine, and CRP-to-albumin ratios for mortality in patients on maintenance hemodialysis.
This study checked if certain blood test results can predict death in dialysis patients. It looked at ratios of different chemicals in the blood. The results showed some of these...
The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor-伪Klotho Complex Increases Sinoatrial Electrical Activity.
This study looked at a protein called FGF23 in the heart. It tested how this protein affects the heart's electrical signals. The work was done in mouse cells, not in people yet. It...
High-Flow Nasal Oxygen Versus Conventional Oxygen Therapy and Non-Invasive Ventilation for Acute Respiratory Failure in the Emergency Department: A Systematic Review and Meta-Analysis.
This review combined many studies on how to help people with sudden breathing trouble in the emergency room. It compared a high-flow oxygen tube with other breathing aids. The goal...
An individual patient meta-analysis assessed the associations between change in albuminuria and acute changes in the glomerular filtration rate in randomized controlled trials of chronic kidney disease progression
This study looked at data from many large trials on kidney disease. It checked if a drop in protein in the urine meant the kidneys were getting worse. It found a strong link...
Trends in Iron Indices among Non-Dialysis Chronic Kidney Disease Patients with Anemia.
This study looked at 50 people with kidney disease and low blood counts. It checked their iron levels over six months. The study found a link between the iron levels and the...
Positive modulation of glucagon-like peptide 1 (GLP-1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes.
This study looked at a small protein called a haemorphin. It tested how this protein affects cells in the lab. It found that the protein helped the cells control sugar. This was in...
Finerenone in IgA nephropathy: A Systematic Review of Real-world Studies.
This is a review of real-world studies on finerenone, a drug used to slow kidney decline. It looks at how the drug works in people with IgA nephropathy. There are no new results...
Berberine attenuates diabetic kidney injury via FOXO1/SP1-associated regulation of renal SGLT-2 expression.
This study looked at how berberine, a plant compound, affects kidney cells. It was done in mice and human kidney cells, not in people yet. The results suggest it may help protect...
Iatrogenic hypercalcemia in a patient with type 2 diabetes and chronic kidney disease
This is a case report about one man with high calcium levels. It happened while he took several kidney and diabetes drugs. It is a single story, not a large study.
Metabolite-based Analysis of High-Risk Factors on Occurrence of AKI in Patients with Acute Myocardial Infarction
Researchers looked at 124 people who had a heart attack. They found that certain blood markers could predict who would get kidney injury. This study shows a link between these...
The CKM鈥揋DM multi-organ precision model: reframing gestational diabetes as an early cardiovascular鈥搆idney鈥搈etabolic event in Southeast Asia
This review discusses how gestational diabetes in pregnancy is an early sign of heart and kidney risk. It focuses on patients in Southeast Asia. There are no new results from a...
Predictors of Antibody Response to Hepatitis B Vaccination in Hemodialysis Patients.
Researchers studied 50 people on dialysis to see how well they responded to the hepatitis B vaccine. They found that some patients did not build up enough protection. This shows a...
Comparative review of glycated albumin detection from conventional colorimetric assays to Raman spectroscopy, surface-enhanced Raman scattering, and surface plasmon resonance.
This review compares different ways to measure a blood marker for blood sugar. It is useful for people with kidney disease who need accurate tests. There are no new results from a...
Targeting biglycan-TLR2/TLR4 interaction with synthetic peptides mitigates inflammation and ameliorates renal function in ischemia-reperfusion injury.
Researchers tested a new treatment for kidney injury in animals and cells. It helped reduce inflammation and improve kidney function. This was not tested in people yet.
EFFECT OF ANTIDIABETIC THERAPY AND DRUG INTERACTIONS IN PATIENT WITH HYPERTENSION AND KIDNEY DISEASE
This study looked at 301 people with type 2 diabetes, high blood pressure, and kidney disease. It compared oral and injectable diabetes drugs to check for side effects and drug...
Gigantol Ameliorates High-Fat and High-Fructose Diet-Induced Chronic Kidney Disease by Promoting TFEB-Mediated Mitophagy to Suppress Ferroptosis
A plant compound called gigantol helped protect the kidneys of mice that ate a high-fat and high-fructose diet. The study showed it improved kidney function in the animals. This...
SGLT2 inhibitors as a strategy for volume management in peritoneal dialysis: a case series
This study looked at seven people on peritoneal dialysis who took a drug called an SGLT2 inhibitor. The researchers tracked how much fluid the patients removed from their bodies....
Risk Factors for Chronic Kidney Disease among Patients in Selected Dialysis Centers of Kerala: A Descriptive Study with Nursing Implications
This study looked at 190 people on dialysis in India. It checked for health risks like lifestyle habits and social factors. The results show a link between these factors and kidney...
Maternal Obesity Induces DNA Methylation Changes in the Kidneys and Blood of Rodent Offspring at Adulthood
This study used mice to see how a mother's weight affects her baby's kidneys. It found that high-fat diets in mothers changed the DNA in the offspring. This suggests a link between...
Cardiorenal effects of SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal mineralocorticoid receptor antagonists in type 2 diabetes: a systematic review and meta-analysis
This review combined data from many large trials. It looked at three types of diabetes drugs. The results show these drugs help protect the heart and kidneys. This is a strong...
Relationship between Anemia and Albuminuria and Chronic Kidney Disease in Korean Adults with and without Metabolic Syndrome: Analysis of the 2020 Korea National Health and Nutrition Examination Survey
This study checked 4,943 adults in Korea. It looked at low blood count and kidney function. It found a link between low blood count and worse kidney health. This is an...
Leveraging Bioinformatic Strategies to Advance Care of Children With Urinary Tract Infections
This is a review of how computer tools can help find kidney risks in children. It discusses new ways to diagnose infections. There are no new results from a specific trial in this...
High-Sensitivity Cardiac Troponin T is Associated with Acute Kidney Injury in Emergency Department Patients
This study looked at 23,292 emergency room visits. It found a link between a heart protein and sudden kidney injury. This is an observational study, so it shows a link, not proof...
Association between peripheral blood eosinophil count and kidney replacement therapy initiation risk in patients with nephrosclerosis
This study is about a link between blood cells and kidney failure. The record does not include an abstract. We have not read the full study, so there are no details to report yet.
Experimental Nephrotoxicity Models for Screening Nephroprotective Agents: Comparative Evaluation, Biomarkers, Translational Relevance, and Emerging Alternatives
This is a review of how scientists test drugs in the lab. It compares different animal models for kidney damage. It discusses how these tests might apply to people. There are no...
U-Shaped Association between Whole Blood Selenium and Cancer Mortality in U.S. Adults with Chronic Kidney Disease: A NHANES-Based Cohort Study
This study looked at 1,941 adults with kidney disease in the U.S. It checked blood levels of a mineral called selenium. It found a link between selenium levels and cancer death....
Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review)
This review looks at how kidney stones form in a specific area of the kidney. It explains the cell changes that build up the plaque where stones attach. There are no new trial...
Immunomodulatory Effects of the Calcitriol Analog Paricalcitol
This review examines how a vitamin D drug affects the immune system in kidney disease. It summarizes existing lab and patient data. There are no new trial results in this paper.
Outcomes after technically successful transjugular intrahepatic portosystemic shunt for conventional indications and high-risk clinical subgroups: a multicenter cohort study
This study looked at liver patients who had a shunt procedure. It checked if the procedure helped people with kidney issues survive longer. It shows a link, not proof of cause.
PERSONALIZED ENDOSCOPIC HEMOSTASIS WITH OTSC CLIPS FOR HIGH-RISK GASTRODUODENAL ULCER BLEEDING: A PROSPECTIVE STUDY
This study looked at stomach bleeding in patients with other health problems. It tested a specific clip method to stop the bleeding. It shows a link, not proof of cause.
Melatonin and Diabetic Nephropathy: From Mechanistic Pathways to Translational Opportunities in Clinical Management.
This is a review of research on melatonin, a hormone that helps with sleep. It looks at how melatonin might help protect kidneys in people with diabetes. The article explains the...
Semaglutide in type 2 diabetes and chronic kidney disease in Australia: practical clinical considerations from a multidisciplinary panel.
This review gives practical advice for doctors in Australia on using semaglutide. It notes that this drug slowed kidney decline by 24% in a major trial. The panel discusses how to...
Finerenone versus spironolactone in heart failure with mildly reduced or preserved ejection fraction: a real-world study.
This study compared two heart failure drugs, finerenone and spironolactone, in real-world patients. It looked at who lived longer or had fewer hospital visits over 12 months....
Impact of the Four Pillars on Electrolyte Derangements during State-of-the-Art Therapy for Diabetic Kidney Disease.
This review looks at how four main kidney drugs affect the body's salt and water balance. It explains the risks of high or low levels of certain minerals. The goal is to help...
Polygenic Risk Scores of Coronary Heart Disease in Chronic Kidney Disease Population: The CRIC Study.
This study checked if a person's genetic risk for heart disease can predict heart problems in people with kidney disease. It found that adding this genetic score to standard risk...
Estimated Glomerular Filtration Rate and Associated Factors Prior to Anti-Tuberculosis Initiation Among Tuberculosis Patients at Bale Zone Hospitals Southeast Ethiopia: A Cross-Sectional Study Design.
This study checked kidney function in people with tuberculosis in Ethiopia. It looked at kidney filtering rates before treatment started. The results show a link between the...
Dietary Salt Intake and Hypertension in Chronic Kidney Disease.
This review explains how salt affects blood pressure in people with kidney disease. It describes how the body holds onto salt as kidneys weaken. This leads to high blood pressure....
Association of Remnant Cholesterol Levels With Kidney Replacement Therapy Initiation in Korean Patients With Chronic Kidney Disease: A Prospective Cohort Study.
Researchers followed Korean patients with kidney disease to see if cholesterol levels matter. They looked at a specific type of cholesterol called remnant cholesterol. The study...
Chronic kidney disease in type 2 diabetes: Identifying key risk factors from Johor national diabetes registry study.
This study used data from a diabetes registry in Malaysia. It looked for factors that link type 2 diabetes to kidney disease. The results identify key risk factors for kidney...
Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure in Children and Adolescents: A Single-Arm and Pairwise Systematic Review and Meta-Analysis with GRADE Assessment of the Evidence.
A large review looked at a common diabetes drug for children with heart failure. It combined data from 9 studies involving 599 children. The drug was safe, with low rates of death...
SGLT2 inhibitors: mechanisms, physiology and pharmacology, and clinical applications.
This review explains how a common diabetes drug works in the body. It describes how the drug changes kidney function and blood flow. It does not report new trial results. It is a...
Bridging the gap in early cardio-renal risk prevention in type 2 diabetes: evidence, guidelines, and real-world insights from the PRECARE NO LiMITS initiative.
This review discusses how to protect the heart and kidneys early in diabetes. It looks at real-world data from a large educational project. It does not report new trial results. It...
Global, Regional, and National Burden of Heart Failure, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023.
This study looked at data from 204 countries to count how many people have heart failure. It covers the years 1990 to 2023. The results show that heart failure is a very common...
Trained Immunity as a Mechanistic Bridge Between Uremic Toxins, Atherosclerosis, and Vascular Calcification in Chronic Kidney Disease.
This review explains how toxins build up in the blood during kidney disease. It links these toxins to hardening of the arteries. It does not report new trial results. It helps...
Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial.
A large trial tested a new diabetes drug called orforglipron. It compared this drug to insulin in people with type 2 diabetes. The study found the new drug was safe for the heart....
Physcion attenuates renal fibrosis by disrupting PKM2-FAK1 interaction and suppressing the FAK1/ERK signaling axis.
This study tested a plant compound called physcion in mice and cells. It found the compound reduced scarring in the kidneys. This was done in animals, not people yet. It shows a...
Association of peripheral TLR9 gene expression with renal function and inflammatory cytokine profile in chronic kidney disease: A case-control study.
This study compared 60 people with kidney disease to 60 healthy controls. It found that a specific gene was more active in the sick group. It shows a link between this gene and...
Preoperative Renal Impairment and Oncological Outcomes After Radical Cystectomy: A Multicenter Cohort Study.
This study looked at 396 people with bladder cancer who had kidney issues. It found that lower kidney function was linked to worse cancer outcomes. It shows a link, but it does not...
Prognostic value of functional capacity assessed by the Glittre Activities of Daily Living test in hemodialysis patients: a prospective observational study.
This study tested how well dialysis patients could do daily tasks. It used a specific test to measure their physical ability. The results showed that people who could do more tasks...
Control the Pressure, Protect Your Future: Heart and Kidney Health Explained
This video explains how high blood pressure affects the heart and kidneys. It gives tips on how to protect your health. There are no new study results in this video.
A CASE STUDY ON THE AYURVEDIC MANAGEMENT OF BILATERAL RENAL CALCULI (VRIKKASHMARI)
This is a case study on using Ayurvedic medicine to treat kidney stones. It describes one person's experience with this treatment. There are no new results from this item yet.
DIABETIC NEPHROPATHY AS AN ANUKTA VYADHI: AN INTEGRATIVE REVIEW WITH AYURVEDIC CONCEPTS AND CONTEMPORARY PERSPECTIVES
This is a review that looks at diabetic kidney disease through Ayurvedic concepts. It connects traditional ideas with modern medicine. There are no new results from this item yet.
Lactobacillus and Tryptophan Supplementation Improve Renal Function and are Associated with Metabolomic Alterations in a Mouse Model of Chronic Kidney Disease
Mice with kidney disease were given a probiotic and a nutrient. The treatment improved kidney function in the animals. This was done in mice, not people yet. It suggests these...
High-Protein Intake Impact on Human and Animal Kidney Function Across the Lifespan: Clinical Evidence and Emerging Concepts
This is a narrative review that summarizes what is known about high-protein diets and kidney function. It looks at both human and animal data. There are no new results from this...
Physical Performance and Risk of Heart Failure, Kidney Failure, and Mortality in CKD
People with kidney disease who had lower physical performance scores were more likely to develop heart failure or die. This study shows a link, not proof of cause. It tracked a...
Gambaran Kendala Diet pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis di Rumah Sakit Akademik Universitas Gadjah Mada
This study looked at the diet challenges faced by people on dialysis. It describes the barriers patients hit when trying to follow strict food rules. It shows a link between these...
Food and Health: Nutrition for Prevention and Management of Cardiovascular Disease: 2026 ACC Scientific Statement: A Report of the American College of Cardiology.
This is a guide from a major cardiology group. It talks about how food affects heart and kidney health. It suggests eating whole foods and less processed food. There are no new...
The oral und systemic health risks of sugar consumption: an umbrella review.
This review looks at how sugar affects overall health and teeth. It summarizes many other studies on sugar and disease. It does not report new trial results. It shows that sugar...
Identification of shared and divergent molecular pathways linking ambient air pollutants to mortality and major chronic diseases through proteomic profiling.
This study looked at 48,645 people to see how air pollution affects the body. It found a link between dirty air and higher risks of death and chronic diseases. The research shows a...
Renal function trajectories before and during the COVID-19 pandemic in Japanese individuals with type 1 diabetes: a post-hoc analysis of the multicenter retrospective investigation by the IPRA-CKD study group.
This study tracked 190 people with type 1 diabetes over 60 months. It looked at how kidney function changed before and during the pandemic. It shows a link between lifestyle...
A decade of progress: Declining readmissions for dehydration and acute kidney injury after bariatric surgery.
This study looked at national data from 2015 to 2023. It found that fewer people were readmitted to the hospital for dehydration and kidney injury after weight loss surgery. It...
Phytochemical Analysis of Moroccan Mercurialis annua L. and Its Nephroprotective Activity: Evidence Supporting Traditional Renal Uses.
This study tested a plant extract in rats. It found the extract protected the kidneys from damage caused by a drug. This was done in animals, not people yet. It supports the idea...
Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.
This is a review article that explains how the body controls inflammation during stress. It discusses how hormones help the immune system respond to danger. There are no new...
A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes.
This study created a score to measure how much the body is aging at the cell level. It used blood tests to track this aging process. The results showed that a higher score was...
Effects of Tai Chi Qigong on sleep quality in older male cancer survivors: A randomized controlled clinical trial.
Older men with cancer who did a gentle movement practice called Tai Chi Qigong had better sleep than men who did regular exercise or usual care. The study was small, with 113...
Changes in Cognition, Depressive Symptoms and Functional Limitation Before and After Incident Chronic Kidney Disease: A Three-Cohort Longitudinal Study
This study tracked 75,044 adults over many years. It looked at memory, mood, and physical ability. It found a link between new kidney disease and changes in these areas. This is an...
KLOTHO AS A THERAPEUTIC TARGET IN RENAL FIBROSIS: MECHANISMS, PHARMACOLOGY, PRECLINICAL EVIDENCE, AND TRANSLATIONAL PRIORITIES
This is a review of Klotho, a protein that may help reverse kidney scarring. It looks at how it works in animal studies. There are no new results from this item yet.
MAFA drives pancreatic islet maturation through coordination of cell growth, metabolic maturation, and resilience to stress.
This study used lab-grown cells to see how a protein called MAFA helps insulin cells mature. It found that this protein helps cells grow and handle stress better. This work was...
Age-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair
This study looked at how a specific protein affects bone healing in mice. It found that this protein works differently in young versus old animals. This work was done in animals,...
Endothelial-Fibroblast Organoids Generated in Hydrogel Microchamber Arrays: A Translational Model of Vascular Dysfunction in Cardio-Kidney-Metabolic Disease.
Researchers built a new lab model to study how blood vessels fail. They used tiny 3D clusters of cells to mimic the body's response to disease. This work was done in a lab, not in...
Plant-Derived Flavonoids Ameliorate Diabetic Nephropathy: Molecular Mechanisms and Therapeutic Potential.
This is a review of research on plant compounds and diabetic kidney disease. It looks at how these compounds might protect the kidneys at a molecular level. It is a summary of...
Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.
This study compared lung health in people on dialysis and people who had a kidney transplant. It measured how well they could breathe and checked for damage to blood vessels. The...
Apixaban Use Before Kidney Transplantation: Is Reversal Necessary?
This study looked at people taking a blood thinner called apixaban before a kidney transplant. It checked if they needed a special drug to stop the blood thinner before surgery....
Speckle Tracking Analysis of the Left and Right Heart in Type 1 Diabetes Patients with End-Stage Renal Disease Awaiting Simultaneous Pancreas鈥揔idney Transplantation
This study looked at heart scans of 16 people with type 1 diabetes and end-stage kidney disease who were waiting for a transplant. It checked for signs of heart muscle damage. This...
System-level Barriers Reducing Access to Transplantation: Results of a Global Survey.
This study surveyed doctors and surgeons around the world to find out why it is hard to get more organs for transplant. It looked at hospital rules, laws, and money issues. The...
Acceptance of Organs From Deceased Donors: Results of a Global Survey.
This survey asked specialists how comfortable they are with accepting organs from people who have died. It found that many doctors feel they need more training to make these...
Mind the Gap: Disparities in Education on Organ Donation and Transplantation-Results of a Global Survey.
This study checked how easy it is for doctors to get training on organ donation and transplant. It found big differences between countries in how much education is available. The...
Risk Adjustment in the Medicare Advantage Population Using Encounter Data.
This study looked at how health plans pay for care for older adults. It used data from Medicare Advantage plans to check if payments match the real cost of care. The goal was to...
https://www.kidney.org/news-stories/kidney-disease-changed-nfl-star-khalen-saunders-s-family-now-he-s-raising-awareness
This is a news story about an NFL player who is raising awareness for kidney disease. It is not a research study, so there are no results yet.
Epidemiology, diagnosis, and prognosis of Peripheral Arterial Disease and Cardio-Renal Syndrome: Evidence from systematic reviews and data from routine clinical practice
This is a preprint that reviews how heart, blood vessel, and kidney diseases are connected. It discusses how these conditions often happen together. There are no new results from...
NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN [NGAL] AS A DIAGNOSTIC AND PROGNOSTIC BIOMARKER
This is a review of NGAL, a protein that can show early signs of kidney injury. It looks at how well this marker works in tests. There are no new results from this item yet.
ARTIFICIAL INTELLIGENCE IN DIABETES MANAGEMENT: EMERGING APPLICATIONS, CLINICAL OPPORTUNITIES AND CHALLENGES
This is a review of how artificial intelligence is being used to manage diabetes. It looks at how AI can help with treatment and care. There are no new results from this item yet.
ESTIMATING THE PREVALENCE OF SECONDARY HYPER PARATHYROIDISM IN CHRONIC KIDNEY DISEASE
This is a study that looks at how common high parathyroid hormone is in people with chronic kidney disease. It aims to find out how many patients have this condition. There are no...
Assessment of Aluminum, Barium, and Copper Levels in the Blood of Hemodialysis Patients in Ramadi City, Anbar Governorate, Iraq
This is a study that measured heavy metals in the blood of 60 dialysis patients. It compared them to 60 healthy people. There are no new results from this item yet.
Persistent Cardiac Surgery-Associated Acute Kidney Injury Identifies a High-Risk Phenotype after Pediatric Congenital Heart Surgery
This is a preprint about kidney injury in children after heart surgery. It is not yet peer reviewed. There are no final results to report.
Development of a prediction model for aneurysmal events to guide imaging surveillance in autosomal dominant polycystic kidney disease
People with a genetic kidney disease called ADPKD have a higher chance of brain aneurysms. This study looked at 1,267 patients to find a way to predict who is at high risk. It...
Laparoscopic nephrectomy in patients with renal exclusion secondary to urolithiasis. Which factors can predispose conversion to open surgery?
This article discusses kidney removal surgery for stone disease. It is published but has no abstract. We cannot confirm the specific findings or results from the text provided.
Technique Failure in Peritoneal Dialysis: A Comparative Study of Diabetic and Non-Diabetic Patients in Northern Hunan Province, China
This is a preprint comparing dialysis failure in people with and without diabetes. It is not yet peer reviewed. There are no final results to report.
Use of Non-Vitamin K Antagonist Oral Anticoagulants and Risk of Acute Kidney Injury: A Retrospective Cohort Study
This study looks at blood thinners and sudden kidney injury. It is published but has no abstract. We cannot confirm the specific findings or results from the text provided.
DIAGN脫STICO CL脥NICO E PROTOCOLOS DE TRATAMENTO DA S脥NDROME NEFR脫TICA IDIOP脕TICA NA INF脗NCIA
This article reviews how to diagnose and treat a kidney condition in children. It is a review of existing protocols. It does not report new trial results.
Renal Osteodystrophy in a Case of Suspected Plasma Cell Neoplasm
This is a case report about bone and kidney changes in one patient. It is published but has no abstract. We cannot confirm the specific findings or results from the text provided.
https://www.theisn.org/blog/event/isn-webinar-c3g-biopsy-interpretation-monoclonal-gammopathy-and-complement-inhibition/
This is a page for a kidney doctor webinar. It covers how to read kidney biopsies and treat certain conditions. There are no new trial results in this event.