← brief for 2026-09-30 · Slowing decline

Physcion attenuates renal fibrosis by disrupting PKM2-FAK1 interaction and suppressing the FAK1/ERK signaling axis.

Article D Peer reviewed Preclinical

Key takeaways

This study tested a plant compound called physcion in mice and cells. It found the compound reduced scarring in the kidneys. This was done in animals, not people yet. It shows a possible path for future drugs to slow kidney decline.

Who did this work

Zhang Z · Wang L · Zou S · Lei M · Tong K · Zhang M · Xu W · Cheng L · Yang C · Chen L · Cao J · Jiao H

Source

Article · PubMed, CKD progression and prevention · 2026 Sep 24
https://pubmed.ncbi.nlm.nih.gov/42815262/