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Gigantol Ameliorates High-Fat and High-Fructose Diet-Induced Chronic Kidney Disease by Promoting TFEB-Mediated Mitophagy to Suppress Ferroptosis

Key takeaways

A plant compound called gigantol helped protect the kidneys of mice that ate a high-fat and high-fructose diet. The study showed it improved kidney function in the animals. This was done in mice, not people, so it is not proof that it works for humans.

Who did this work

Yingying Song (Hubei University of Chinese Medicine) · Yurou Huang (China Three Gorges University) · Yaxin Huang (China Three Gorges University) · Yingxi Luo · Han Zhao (China Three Gorges University) · Renwu Qin (China Three Gorges University) · Simeng Xiao (China Three Gorges University) · Cong Zhang (China Three Gorges University)

Source

Article · OpenAlex, CKD works · 2026-09-29
https://doi.org/10.1021/acs.jafc.6c05807