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Maternal Obesity Induces DNA Methylation Changes in the Kidneys and Blood of Rodent Offspring at Adulthood

Article D Peer reviewed Preclinical

Key takeaways

This study used mice to see how a mother's weight affects her baby's kidneys. It found that high-fat diets in mothers changed the DNA in the offspring. This suggests a link between early life and later kidney disease. This was done in animals, not people yet.

Who did this work

Benjamin P. Larkin (Royal North Shore Hospital) · Long The Nguyen (Royal North Shore Hospital) · Naveen Kumar Parthiban (Royal North Shore Hospital) · Hui Chen (University of Technology Sydney) · Alen Faiz (University of Technology Sydney) · Kushalee Poornima Jayawickreme (Royal North Shore Hospital) · Sarah J. Glastras (Royal North Shore Hospital) · Carol A. Pollock (Royal North Shore Hospital) · Sonia Saad (Royal North Shore Hospital)

Source

Article · OpenAlex, CKD works · 2026-09-29
https://doi.org/10.3390/nu18193212