← brief for 2026-09-30 · Slowing decline

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure in Children and Adolescents: A Single-Arm and Pairwise Systematic Review and Meta-Analysis with GRADE Assessment of the Evidence.

Article A Peer reviewed Meta-analysis or large trial

Key takeaways

A large review looked at a common diabetes drug for children with heart failure. It combined data from 9 studies involving 599 children. The drug was safe, with low rates of death or need for a transplant. This is the first time data for young patients has been pooled.

Who did this work

Aldossary LA · Alanazi RM · Almutairi RM · Mugibel TA · Ghanam KD · Ben-Obaidellah RAR · Mohammed KA · Alharbi AA · Almahabi JA · Alzahrani RAS · Abu-Qasem HS · Elkasaby MH

Source

Article · PubMed, the drug frontier · 2026 Sep 29
https://pubmed.ncbi.nlm.nih.gov/42814855/