Kidney research, 2026-09-22
New tools help doctors spot kidney risks earlier, but no new cures arrived today.
Today's news focuses on better ways to monitor kidney health rather than new treatments. Most studies are observational, meaning they show links between factors and kidney issues but do not prove cause and effect. A new biobank in Iran is also starting to collect samples to help find early warning signs.
More than meets the eye: a case of tubulointerstitial nephritis and uveitis syndrome.
A 57-year-old woman had a rare condition that inflamed her eyes and kidneys. Doctors treated her with steroids. Her kidney function improved greatly. This is a single patient...
CKDu and Heat Stress Nephropathy Across Eras: Regional Heterogeneity, Occupational Evidence, and Prevention in a Warming World.
This review looks at a kidney disease caused by extreme heat and hard labor. It is called heat stress nephropathy. The review summarizes what is already known. It does not report...
Enhanced urea uptake promotes bleeding in advanced CKD
This article discusses how a waste product called urea affects bleeding in people with late-stage kidney disease. It is a news page, not a full study. There are no new results yet.
Diagnosis of Acute Kidney Injury During Pregnancy.
This review explains how doctors diagnose sudden kidney damage during pregnancy. It covers how this condition affects mothers and babies. There are no new results from this paper,...
Protective effects of green tea (Camellia sinensis (L.) Kuntze) against kidney diseases: a narrative review.
This review looks at how a compound in green tea might help protect the kidneys. It summarizes past studies on how this compound fights inflammation and stress in cells. There are...
Kidney-Brain Axis: In Renal Failure, Cardiotonic Steroids Stimulate Collagen-I in the Hypothalamus and Claudins 1 and 7 in the Choroid Plexus.
Rats with kidney failure have high levels of marinobufagenin (MBG), a hormone-like substance. The researchers found it raised collagen-1, a protein linked to scarring, in a part of...
Application of a Kidney Hierarchical Composite Endpoints in Trials of CKD Progression: Report of a Scientific Workshop Sponsored by the National Kidney Foundation
This is a workshop report from the National Kidney Foundation, not a study, so there are no results. Experts discussed a new way to score drug trials for chronic kidney disease...
A Perspective on the Role of Nephrologists in the Cardio-Kidney-Metabolic Syndrome
This is an opinion piece with no new results. It says kidney doctors should shift their focus. Instead of mainly treating kidney failure with dialysis and transplants, they should...
Congenital Anomalies of the kidney and urinary tract: pediatric origins and adult outcomes
This review covers kidney and urinary tract defects that babies are born with, called CAKUT. They make up 20% to 30% of all defects found before birth, and about 3.83 of every...
A Multimodal Study of Late Gadolinium Enhancement in Uremic Cardiomyopathy: Association of ECM Changes with Gadolinium Deposition
Researchers used 12 rats to study how kidney disease changes the heart. They gave the rats a special dye to see where it settled in the heart tissue. This was done in animals, not...
Pericardial effusion and in-hospital mortality in adults hospitalized with severe or greater tricuspid regurgitation: A multicenter registry study
This study looked at people with a specific heart valve problem called tricuspid regurgitation. It found that fluid around the heart was linked to a higher chance of dying in the...
Association of PM2.5 changes with advanced kidney disease progression and mortality in patients with early CKD: a nationwide retrospective cohort study in Taiwan
This large study followed 472,141 people with early kidney disease in Taiwan. It found that cleaner air was linked to slower disease progression and lower death rates. Because it...
IgG4-Related Disease of the Liver and Kidney: Diagnostic Integration for Emergency Medicine
This paper reviews how to spot a rare immune condition that affects the liver and kidneys. It helps doctors avoid misdiagnosing it as cancer or infection. It is a review of...
Diuretic-Associated Electrolyte Imbalances in Cardiovascular and Renal Disorders: A Clinical Pharmacists' Perspective
This review explains how water pills can upset the body's salt and mineral balance. It notes that these changes are common and can cause heart rhythm problems. There are no new...
Association of patient characteristics with changes in estimated glomerular filtration rate before and after arteriovenous fistula/graft creation: a retrospective study
This study looked at how kidney function changes after creating a dialysis access. It checked if certain patient traits affect this decline. It is an observational study, so it...
Macroalbuminuria as a marker of cardiac damage in patients with type 2 diabetes: insights from multimodality cardiac imaging and biomarkers
Doctors checked if high protein in the urine links to heart damage. They studied 49 adults with diabetes and stage 3 kidney disease. The study found a connection between kidney...
Beyond the Pocket: Clinical, Routine Biomarker, and Microbiological Associations with Systemic Versus Localized Cardiovascular Implantable Electronic Device Infection
This study looked at 75 adults with infections in their heart devices. It tried to find signs that predict if the infection will spread to the whole body. It is an observational...
Monckeberg’s Medial Sclerosis in Athletes: Report of Two Cases and Possible Pathophysiological Mechanisms
This report describes two athletes who had a rare type of artery calcification. It is usually seen in people with diabetes or kidney disease. Since this is a case report, there are...
Association of Estimated Pulse Wave Velocity with Chronic Kidney Disease Risk: A Machine Learning Analysis Based on NHANES and CHARLS
Researchers checked if stiff blood vessels are linked to kidney disease. They used data from about 100.9 million people in the US and 21,853 in China. The study found a connection...
Early insulin combined with metformin therapy and long-term risks of cardiovascular disease, kidney disease, and cancer in newly diagnosed type 2 diabetes: a real-world cohort study in China
This study followed 19,908 people with new type 2 diabetes. It compared those who started insulin and metformin against those who took only metformin. The goal was to see if the...
Development and validation of a risk predictive model for incident chronic kidney disease in prediabetic patients based on time-dependent Cox regression
Doctors built a tool to predict who with prediabetes will develop kidney disease. They used records from patients seen between 2014 and 2024. The tool helps identify people at...
Serum long noncoding RNA human plasmacytoma variant translocation 1 (PVT1) expression levels in Egyptians type 2 diabetic patients and its correlation with severity of diabetic nephropathy.
This study checked blood levels of a specific gene marker in people with diabetes. It found a link between this marker and the severity of kidney damage. It shows a link, not proof...
PREX1 regulates renal fibrosis through the RPTOR-mTORC1 signaling pathway.
This study found a protein called PREX1 that drives kidney scarring. It works by turning on a specific growth signal. The research used human kidney tissue and mice. It was not...
Neutrophil-Mediated Delivery of MRI-Traceable Nanocarriers Ameliorates Acute Kidney Injury and Associated Cognitive Deficits and Anxiety-Like Behaviors.
Researchers created a new drug delivery system using white blood cells. In mice, this system treated sudden kidney damage. It also helped with brain fog and anxiety. This was a lab...
Ratio of extracellular water and body cell mass is associated with coronary artery calcification in peritoneal dialysis patients
This study looked at people starting dialysis. It found a link between having too much fluid in the body and hardening of the heart arteries. This shows a connection, but it does...
A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery
This is a new test of a drug called ilofotase alfa. It aims to stop kidney damage in people having heart surgery. The study is starting, so there are no results yet.
Early renal replacement therapy and short-term mortality in higher-risk KDIGO stage 2 sepsis-associated acute kidney injury with sustained oliguria: a target trial emulation
This study looked at hospital records for people with severe infection and low urine output. It checked if starting dialysis early was linked to survival. It shows a link, but it...
Relationship between inadequate control of hypertension and the development or progression of kidney disease
This piece discusses how high blood pressure affects the kidneys. It is a general discussion, not a specific study with new data. There are no trial results to report.
Cardiovascular kidney metabolic syndrome from pathophysiological interaction to integrated clinical management
This review explains how heart, kidney, and metabolic health are linked. It describes a new way to stage these conditions. It is a summary of existing knowledge, not a new trial...
Oral Semaglutide in Routine Clinical Practice: 24-Month Real-World Effectiveness, Persistence and Safety in Adults With Type 2 Diabetes.
This study followed 232 adults with type 2 diabetes who took a daily pill called semaglutide. It looked at their health over 24 months. The study shows a link between the drug and...
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
This study is testing a pill called roxadustat in children with kidney disease. It aims to treat low red blood cell counts, or anemia. The study will last up to 52 weeks. There are...
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
This is a new study that is just starting. It will test a drug called clazakizumab in adults with high inflammation markers. The goal is to see if it lowers the risk of heart...
Correction: Risk stratification and prognostic outcomes in intracerebral hemorrhage among patients with chronic kidney disease: a population-oriented meta-analysis
This is a correction to a previous study about brain bleeds in people with kidney disease. It fixes errors in the original paper. There are no new results in this item.
The ‘Known Unknowns’ of CKD of Undetermined Etiology In 2026
This article discusses a type of kidney disease where the cause is unknown. It is often seen in farm workers in poor countries. The piece reviews what is still not known about the...
Is there an interaction between hypertension and proteinuria in pediatric chronic kidney disease progression? Evidence from the SP-CKD-Kids cohort
This study followed 254 children with kidney disease for about 3 years. It looked at how high blood pressure and protein in the urine affect kidney decline. This shows a link, not...
Antiproteinuric Response to Finerenone in Diabetic Kidney Disease: Responder and Non-Responder Subgroup Analysis of the FINDKDLATAM Study
This analysis looked at how people with diabetic kidney disease reacted to a drug called finerenone. It checked if the drug reduced protein in the urine. This shows a link, not...
Neuregulin 4 in correlation with flow mediated dilatation and transcranial Doppler in assessment of endothelial dysfunction in type 2 diabetic kidney disease patients
Researchers studied 120 people to check blood vessel health in diabetic kidney disease. They measured a protein called Neuregulin 4 and how blood vessels open. This is an...
U-shaped association of serum potassium with all-cause mortality in patients with atrial fibrillation and chronic kidney disease: a retrospective cohort study
This study looks at potassium levels in people with heart rhythm issues and kidney disease. It is a retrospective cohort study. There is no abstract, so there are no results yet.
Impact of Metabolic Syndrome on SVIP and p97/VCP Expression in Renal Tissue
This study looked at kidney tissue from people with metabolic syndrome. It checked how two proteins, SVIP and p97/VCP, behave. This was in tissue samples, not a test in people yet.
Association between early systolic blood pressure and clinical outcomes in non-critically ill patients with sepsis-associated acute kidney injury: a retrospective cohort study
This study looked at blood pressure in people with sepsis and sudden kidney injury. It checked how early blood pressure linked to one-year outcomes. This is an observational study,...
Robinetin Alleviates Streptozotocin-induced Diabetic Nephropathy in Rats by Mitigating Oxidative Stress and Inhibiting Inflammatory Cascades
This study tested a plant compound called robinetin in rats with diabetes. The rats had kidney damage from high blood sugar. The compound helped reduce stress and swelling in the...
From glucolipotoxicity to cardiorenal injury: mitophagy imbalance in the cardiovascular–kidney–metabolic syndrome continuum
This review explains how high blood sugar and fat can hurt the heart and kidneys at the same time. It describes the body's internal processes, but it does not report new trial...
Erythropoiesis-stimulating agent hyporesponsiveness in chronic kidney disease: mechanistic insights and emerging precision approaches
This review explains why some people with kidney disease do not respond well to anemia drugs. It describes the body's internal reasons, but it does not report new trial results.
High Serum Uric Acid Promotes Metastasis by Disrupting Endothelial Functions Through the NF-κB-NOX4 Pathway
This study was done in cells, not in people yet. It found that high uric acid can help cancer spread. It does this by changing how blood vessel cells work.
Iranian Chronic Kidney Disease Biobank as a comprehensive resource for next-generation research: study design and protocol.
This paper describes a new plan to collect blood and urine samples from people in Iran with kidney disease. The goal is to build a large library of samples for future research....
Differential uptake of SGLT2 inhibitors in England following heart failure guideline expansion: a controlled interrupted time series analysis.
This study looked at how often doctors in England prescribed a type of diabetes drug called SGLT2 inhibitors. It found that prescribing habits changed after new heart failure...
Prognostic value of the Edmonton Obesity Staging System among people hospitalized with obesity.
This study checked if a specific scoring system for obesity could predict how sick hospitalized patients would get. It looked at readmissions and deaths within 90 days. This is an...
Administration of Enoximone for the Optimisation of Renal Function in Cardiac Surgery: Final Results of a Multicentre Study.
This study looked at whether a drug called enoximone could protect kidneys during heart surgery. It was an observational study of patients who had the surgery. It shows a link...
Association of mixed metal exposure with kidney injury and benchmark dose estimation in Chinese adults aged 40 years and older.
This study found a link between exposure to certain metals in the body and kidney injury. It was an observational study of 842 adults. It shows a connection, but not proof that the...
Unravelling gut-kidney axis alterations in BPA-related CKD: Integrating network toxicology and machine learning with experimental validation.
This study looked at how a chemical called BPA might affect the gut and kidneys. It used computer models and lab experiments to find possible mechanisms. This was done in cells and...
Development and Feasibility of a Virtual Nutrition Education Intervention for Adults with Non-Dialysis Chronic Kidney Disease
This study created an online diet program for people with stage 3 to 4 kidney disease. It tested if the program was easy to use and practical. It reports on the design and...
Fisetin as a nutritional senotherapeutic: mechanisms, translational promise, and lessons from chronic kidney disease
This review discusses fisetin, a compound found in some foods. It looks at how it might affect aging and kidney disease. It summarizes lab work and theory, but reports no new human...
Dietary magnesium intake modified association between visceral adiposity index and chronic kidney disease: a cross-sectional study
This study looked at 2,616 U.S. adults to see if belly fat and kidney disease are linked. It also checked if eating more magnesium changes that link. Because this was an...
Physical activity and oxidative stress biomarkers in humans: a systematic review and quantitative meta-analysis.
This large review combined many studies on exercise and body stress markers. It looked at how movement changes chemical signs of stress in the blood. The review did not focus on...
Lifestyle Intervention In CKD
This new study will test a 12-week healthy lifestyle program. It includes healthy eating, exercise, and coaching. The goal is to lower blood pressure in people with advanced kidney...
Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study.
Researchers used computer programs to predict which people with diabetes and high blood pressure are at higher risk of dying. This is an observational study, so it shows a link but...
Changes in kidney health before, during, and after the COVID-19 pandemic: a nationwide serial cross-sectional study in Korea.
This study looked at kidney health data from Korea before, during, and after the pandemic. It found changes in kidney function and protein in the urine. This is an observational...
Diagnosing malnutrition in patients on dialysis using the global leadership initiative on malnutrition (GLIM) criteria: bridging the gap between theoretical consensus and real-world applicability.
This study checked if a common malnutrition test works well for people on dialysis. It looked at patients in six Swedish centers. The results show a link between the test and...
A comprehensive proteomic and transcriptomic mapping study found porcine and human kidneys exhibit a profoundly altered biological profile during warm ex vivo perfusion
This research mapped the biological changes in pig kidneys while they were kept alive on a machine. This technique is used to preserve organs before transplant. The study aims to...
Translocator Protein and Mitochondrial Dysfunction in Chronic Kidney Disease
This study used mice to look at a protein called TSPO. It found that when this protein is missing, kidney cells age and scar faster. This was done in animals, not people yet. It...
Kidney organoids as a platform to study plasminogen-induced injury and uPA-based therapies.
Researchers used tiny lab-grown kidney models to study a protein that can damage kidneys. They tested a drug called amiloride to see if it could help. This was done in the lab, not...
Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα.
This study used cells in a lab to look at how kidney transplants get scarred. It found that a specific cell process helps remove damaged parts. This stops the scarring from getting...
Large-scale organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease
Researchers created a way to grow large groups of kidney cells in the lab. These cells can form cysts, which are fluid-filled sacs. This setup helps scientists test new drugs for...
Endothelium-on-a-chip for permeability studies in diabetic and diabetic kidney disease milieu
This study used a tiny chip with cells to test kidney health. It looked at how blood sugar affects the lining of blood vessels. This was in a lab model, not people yet.
Comparison of a New Fully Synthetic Perfusion Solution to Belzer MPS for 24-H Hypothermic Oxygenated Perfusion of Porcine Kidneys: A Feasibility Study.
Researchers tested a new fluid to keep pig kidneys fresh for 24 hours. This was done in animals, not people yet. The goal is to find a better way to store donor kidneys for...
Antibody-mediated rejection of renal allograft presenting as hemorrhagic necrosis mimicking adenovirus nephropathy: a case report and literature review
This report describes one patient whose new kidney transplant failed in a rare way. The tissue damage looked like a virus infection, but it was actually a rejection reaction. It is...
Necrotizing Soft Tissue Infection in a Renal Transplant Patient
This is a report on one patient who had a severe skin infection after a kidney transplant. It describes the treatment for that single case. It is not a large study with general...
Correction to: Kidney biopsy analysis of 14 cases of renal disease after unrelated cord blood transplantation
This is a correction to a study on kidney disease after blood stem cell transplants. It fixes details in the original paper. There are no new results in this item.
Heather afrontó su trasplante con el apoyo de una mentora | NKF Peers
This video tells the story of Heather, a patient who faced her kidney transplant. She found help and comfort by working with a mentor. The clip shares her personal experience and...
Donor and recipient immune programs underlying delayed graft function in kidney transplantation revealed by temporal single-cell profiling
This research examined the immune cells in kidneys that took time to start working after a transplant. It aimed to find the specific cell circuits that cause this delay. The...
The Prevalence of Chronic Kidney Disease (CKD) and its Associated Factors: A Cross-Sectional Study among Civil Servants at the Secretariat Complex in Rivers State, Southern Nigeria
This study screened 300 civil servants in Nigeria to find how common kidney disease is in that group. It also looked at risk factors like blood pressure. As a cross-sectional...
Challenges of clustering disease trajectories in people with multiple long-term conditions using data from 7.2 million patients
Researchers looked at health records from 7.2 million people. They grouped patients based on the pattern of their long-term diseases. This helps doctors see which groups are at...
Percentile charts for eGFR
This study creates new charts to help doctors judge kidney health based on age. It is a new tool, not a test of a treatment, so there are no results yet.
MOLECULAR HOMEOSTASIS, QUANTUM-CHEMICAL EQUILIBRIA, AND THERAPEUTIC MODULATION OF NEPHROLITHIASIS: CONTEMPORARY PHARMACEUTICAL AND CLINICAL OPTIMIZATION
This paper uses advanced chemistry to study how kidney stones form. It is a theoretical review, not a new test with results.
RELATIONSHIP BETWEEN IMPLEMENTATION OF ENHANCED RECOVERY AFTER SURGERY (ERAS) PROTOCOLS AND ACUTE KIDNEY INJURY: A POPULATION-BASED COHORT STUDY IN ALBERTA
This study looks at how a specific surgery recovery plan affects kidney injury. It is a new study, so there are no results yet.
What is the optimal fluid therapy strategy for managing volume depletion in patients with stage 1 acute kidney injury (AKI)?
This is a summary of best practices for giving fluids to people with early kidney injury. It is a review of existing advice, not a new test with results.
Comparison of Serum Calcium, Phosphorus, Alkaline Phosphatase, and Intact Parathyroid Hormone Levels Between Dialysis-Dependent and Non-Dialysis-Dependent Patients With Chronic Kidney Disease: A Cross-Sectional Observational Study
This study compares blood levels of minerals in people with kidney disease. It is a new study, so there are no results yet.
Health literacy inequities in chronic kidney disease: A digital health education programme
This study tests if a digital learning program helps people with kidney disease understand their condition better. It is a new test, so there are no results yet.
Comment on Toki et al. Seasonal BMI Amplitude and Kidney Function Decline in Japanese Adults With Type 2 Diabetes (JDDM 82)
This is a comment on a previous study about weight changes and kidney health in people with type 2 diabetes. It is a discussion, not a new test with results.
Prevalence of Acute kidney Injury in patients with Spontaneous bacterial peritonitis
This study looks at how often sudden kidney injury happens in people with a specific type of belly infection. There are no results yet.
Hubungan Neutrophil-To-Lymphocyte Ratio (Nlr) dengan Kejadian Mortalitas pada Pasien Chronic Kidney Disease (CKD) Rawat Inap di RSUD Waled Cirebon Tahun 2025
This study looked at 30 hospitalized patients with kidney disease. It checked a simple blood test called the Neutrophil-to-Lymphocyte Ratio. The study found a link between this...
Association of Serum Magnesium Levels with Intradialytic Hypotension among Maintenance Haemodialysis Patients
This study looked at 100 people on dialysis. It checked if low magnesium in the blood is linked to low blood pressure during treatment. This shows a link, not proof of cause.
The role of ultrasonography in the evaluation of renal pathologies
This study looked at 40 people who had kidney ultrasounds. It checked how often the scans found stones, cysts, or swelling. This shows a link, not proof of cause.
Population-Level Associations of Diabetes Prevalence and Childhood Overweight with Kidney Cancer Mortality in Türkiye
This study looked at national data from Turkey between 2000 and 2023. It found a link between health spending and kidney cancer death rates. It also looked at diabetes and...
Exploring treatment burden and self-management experiences among adults receiving haemodialysis to inform person-centred digital care: a descriptive qualitative study
This study is about the daily burden of dialysis. It aims to help design better digital care tools. There is no abstract, so there are no results yet.
Correction: A comparative study on the clinicopathological features and short-term prognosis of IgA-dominant infection-related glomerulonephritis and IgA nephropathy
This is a correction to a previous study on kidney inflammation. It fixes details in the original paper. There are no new results in this item.
Cerebrovascular Manifestations in a Family with a Pathogenic COL4A5 Variant
This is a case report about a family with a gene change linked to Alport syndrome. It describes brain blood vessel issues in three generations. It is a single family report, not a...
Efficacy and prognostic value of continuous veno-venous hemofiltration combined with CPFA in sepsis-associated acute kidney injury based on perirenal CT imaging features
This paper is about a kidney filter treatment for people with severe infection. It looks at how well the treatment works and uses scans to check kidney health. There is no...
Prognostic implications of the duration of continuous kidney replacement therapy in 3-month survivors of acute kidney injury: findings from the LINKA cohort
This study checks how long people need a kidney filter to survive. It looks at people who made it past the first three months. There is no abstract, so we do not have the results...
Rethinking high-frequency lithotripsy: a review by EAU endourology group
This is a review of a treatment that uses sound waves to break up kidney stones. It is a general look at the method, not a new test. There is no abstract, so we do not have the...
Chronic pain in the aging adult with sickle cell disease
This review looks at long-term pain in older adults with sickle cell disease. It explains how pain changes as people get older. It is a general review, so it does not report new...
Great saphenous vein arterialisation as a novel technique of vascular conduit preparation for an elective repair of a brachial artery aneurysm
This report describes a surgery on a blood vessel in the arm. The patient had a kidney transplant. It is a single case report, so it does not show what will happen for everyone.
Barriers and enablers of nurses’ infection prevention and control practice in a Philippine hemodialysis unit: A mixed methods study
This study looks at how nurses prevent infections in a dialysis unit. It is a preprint, so it has not been checked by other experts yet. There is no abstract, so we do not have the...
ANCA-associated vasculitis presenting with interstitial lung disease and delayed renal involvement: a diagnostic challenge in an elderly female
This report is about one woman with a rare blood vessel disease. Her lungs were affected before her kidneys. It is a single case, so it does not prove a pattern for all people.
Liver Cirrhosis and Septic Shock Attenuate the Increase in Plasma Endostatin Concentrations That Is Associated with Acute Kidney Injury Requiring Dialysis
This study looked at 258 people with severe infection. It checked a protein in the blood called endostatin. Higher levels were linked to kidney failure. This shows a link, not...