← brief for 2026-09-22 · Slowing decline

Kidney-Brain Axis: In Renal Failure, Cardiotonic Steroids Stimulate Collagen-I in the Hypothalamus and Claudins 1 and 7 in the Choroid Plexus.

Article D Peer reviewed Preclinical

Key takeaways

Rats with kidney failure have high levels of marinobufagenin (MBG), a hormone-like substance. The researchers found it raised collagen-1, a protein linked to scarring, in a part of the brain called the hypothalamus. It also changed proteins in the brain tissue that makes spinal fluid. The team also compared 12 people on dialysis with 6 healthy people, but the abstract we have does not give that result. This is mainly animal research, not people yet.

Who did this work

Romanova IV · Pyankov AA · Kolmakova EV · Isachkina AN · Morina IY · Adair CD · Agalakova NI · Bagrov AY

Source

Article · PubMed, fibrosis reversal · 2026 Sep 17
https://pubmed.ncbi.nlm.nih.gov/42770368/