← brief for 2026-09-22 · Regeneration & devices

Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα.

Key takeaways

This study used cells in a lab to look at how kidney transplants get scarred. It found that a specific cell process helps remove damaged parts. This stops the scarring from getting worse. This was done in cells, not in people yet.

Who did this work

Feng D (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Shen Q (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Zhang J (Department of Urology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.) · Liu J (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Gui Z (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Wang Z (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Han Q (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Fei S (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Chen H (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Sun L (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Tao J (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.) · Han Z (Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.)

Source

Article · Europe PMC, CKD · 2026-09-20
https://doi.org/10.1002/advs.202516953