← brief for 2026-09-22 · Slowing decline

PREX1 regulates renal fibrosis through the RPTOR-mTORC1 signaling pathway.

Key takeaways

This study found a protein called PREX1 that drives kidney scarring. It works by turning on a specific growth signal. The research used human kidney tissue and mice. It was not done in people yet.

Who did this work

Geng X (Department of Urology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China.) · Chen G (Department of Urology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China.) · Qian Y (Department of Urology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China.) · Shan W (Department of Urology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China.) · Li X (Department of Nephrology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China.) · Zhou J (Department of Emergency Surgery, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China. Electronic address: [email protected].) · Wang X (Department of Urology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui 236012, China. Electronic address: [email protected].)

Source

Article · Europe PMC, CKD · 2026-09-21
https://doi.org/10.1016/j.cellsig.2026.112905