Kidney research, 2026-09-11
Today brought no new treatments, only studies that spot patterns worth watching
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Nothing today tested a therapy, so treat everything below as a link between things, not proof that one causes the other.
The strongest item today is a data file behind a review, and almost everything else is observational, meaning researchers watched what happened rather than testing a treatment. Much of the day sat outside stage 3 kidney disease too, covering transplant recipients, children, pregnancy, and blood cancer. Two randomized trials did come in, on meditation and on probiotics, but neither included people with kidney disease. Days like this one build background understanding rather than changing what anyone does tomorrow.
Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective.
This review lays out treatment goals for primary biliary cholangitis, a liver disease where the immune system attacks the small bile ducts. It is written for doctors in Australia....
Dapagliflozin inhibits renal mesangial cell fibrosis by regulating HO-1/TGF-尾1/Smad 2/3 axis.
This lab study tested dapagliflozin, an SGLT2 inhibitor already used in kidney disease, on kidney cells to work out how it reduces scarring. Scarring is the stiff tissue that...
Blood pressure and cardiovascular risk in adults with non-proteinuric chronic kidney disease without diabetes.
This Japanese study followed 287,238 adults with reduced kidney filtering rate (eGFR under 60) who had no diabetes and little or no protein in their urine. It compared blood...
The SGLT2i Treatment Gap in UK Primary Care: A Cross-Sectional RWE Study of Prescribing in Clinical Practice.
This UK study looked at family doctor records to count people who qualify for SGLT2 inhibitors but are not taking them. These are pills that protect the kidneys and heart in type 2...
Complement in Kidney Disease: Core Curriculum 2026
This is a teaching review about complement, a part of the immune system that fights infection but can also attack the kidney when it misfires. It explains that the US Food and Drug...
Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry
Doctors in Japan pulled cases from a national registry of kidney biopsies, the small tissue samples taken to diagnose kidney disease. They described who gets a fast moving kidney...
Association of Serum 1,25-Dihydroxyvitamin D Levels with Erythropoietin Resistance Index-Based Relative Erythropoiesis-Stimulating Agent Hyporesponsiveness in Pre-Dialysis Chronic Kidney Disease
Many people with kidney disease get anemia, meaning low red blood cells, and take drugs that push the body to make more. Some people respond poorly to those drugs. This study...
Tailored B-cell monitoring in podocytopathies: a necessary shift in practice
This is an opinion piece arguing that doctors should track B cells, a type of immune cell, more closely in podocytopathies. Podocytopathies are kidney diseases that damage the...
Nephroprotective Effects of Carvedilol and Sodium Copper Chlorophyllin in Glycerol-Induced Acute Kidney Injury in Female Rats
Researchers gave female rats carvedilol, a blood pressure drug, and sodium copper chlorophyllin, a chlorophyll-based compound, before causing sudden kidney injury with glycerol....
What are the latest guidelines for hyperkalaemia in adults?
This is a short guideline summary on treating high blood potassium, called hyperkalaemia, in adults. High potassium is a common and dangerous problem in kidney disease, because...
Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury
Apelin-13 is a small natural peptide. Giving it before cutting off and then restoring blood flow to the kidney reduced the scarring that followed in older animals. Scarring is what...
Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression鈥攁 narrative review
This is a review article, not a new study. It walks through how high blood sugar changes the cells lining the kidney's small tubes, and how those changes push diabetic kidney...
Complement diagnostics and therapeutics for the pediatric population: early successes and opportunities for further advancement
This review covers tests and drugs that target the complement system in children. The complement system is part of the immune defense, and when it misfires it can attack the...
Oxidative Stress and Renal Function in Severe Preeclampsia and Normal Pregnancy
This study compared kidney function and signs of cell damage from unstable oxygen molecules in women with severe preeclampsia against women with normal pregnancies. Preeclampsia is...
Metal Homeostasis Imbalance as Potentially Contributing Mechanism in Onset of Cardiac Disorders in Individuals with Chronic Obstructive Pulmonary Disease and Chronic Kidney Disease
This study looked at whether an imbalance of metals in the body, things like zinc, copper and iron, is linked to heart problems in people who have both chronic lung disease and...
Enhanced Recovery After Surgery (ERAS) Versus Standard Postoperative Care in Elective Craniotomy for Brain Tumor Excision: A Comprehensive Review of Protocol Differences, Clinical Outcomes, and Implementation Challenges.
This review compares standard recovery care after brain tumor surgery with a structured program called Enhanced Recovery After Surgery. The newer approach cuts back on strong...
Climate Change and Cardiovascular Complications of Diabetes.
This is a discussion piece about how heat waves, cold snaps, and air pollution raise heart and kidney risk for people with diabetes. It notes that people with diabetes handle heat...
Managing headache in primary care: choosing therapies that treat the whole patient.
This review gives family doctors a practical way to treat headaches while taking a patient's other long-term conditions into account. The goal is to use fewer drugs at once and...
Ayurveda in Contemporary Clinical Practice: Integrating Traditional Principles With Preventive, Metabolic, and Mind-Body Medicine.
This article argues that Ayurveda, a traditional Indian system of medicine, could fit into modern care for long-term and stress-related illness. The authors describe its approach...
Evidence Summary of Pruritus Management in Patients With Atopic Dermatitis: Implications for Nursing Practice
This is a summary of the evidence on treating itching in people with eczema, written for nurses. It pulls together existing guidance rather than testing anything new. No abstract...
Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.
This review describes how the brain washes out waste through a drainage network, including the glymphatic system and lymph vessels in the brain's lining. Scientists once thought...
Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus.
A group of brain specialists in Asia agreed on how doctors should spot and treat mild memory and thinking problems, called mild cognitive impairment. They also discussed apps and...
Mindfulness for Saudi Hemodialysis Patients
This is a registration for a study that is starting in Saudi Arabia, so there are no results yet. It plans to test whether guided mindfulness sessions during dialysis improve...
Association of adverse adulthood experiences with cardiovascular kidney metabolic syndrome
This study looked at hard experiences in adult life, such as abuse, money trouble, or losing a home. It checked whether people who went through more of them were more likely to...
A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality
Researchers found a pattern of proteins in the blood that tracks with allostatic load, which is the wear and tear the body takes from long-term stress. People with that protein...
Gut Microbiota in Kidney Transplantation: Mechanistic Insights and Implications for Precision Immunosuppression.
This is a review of what is known about gut bacteria and kidney transplants, not a new study. It describes how the mix of gut bacteria shifts after a transplant, with less variety...
Supporting data for: Metabolic Bariatric Surgery as a Bridge to Kidney Transplantation in Patients with Obesity and Advanced Kidney Disease: A Systematic Review and Meta-Analysis
This is the data file behind a review that pooled results from many earlier studies. It looked at weight loss surgery for people with obesity and advanced kidney disease who want a...
Clinical implications of cardiovascular events in older kidney transplant recipients: a nationwide cohort study
This nationwide study followed older adults who received a kidney transplant and tracked heart problems such as heart attacks and strokes. The aim was to see what those events mean...
Post-Transplant Diabetes Mellitus Risk After Kidney Transplantation
This is a file posted to a public repository about the risk of developing diabetes after a kidney transplant. Diabetes that starts after a transplant is common and is driven partly...
Performance of the iBox Prognostication System in African American Kidney Transplant Recipients
The iBox is a calculator that predicts how long a transplanted kidney will keep working. This study checked how well it performs in African American transplant recipients, a group...
Perceived Child Vulnerability and Protective Behavior by Parents of Children with Chronic Kidney Disease
Researchers asked parents of children with long term kidney disease how fragile they believe their child to be. They then looked at whether that belief changes how protective the...
Patient-reported ratings of transfer to adult care among young adults with chronic kidney disease
Young adults with chronic kidney disease were asked to rate how their move from children's care to adult care went. This handoff is a known weak point, and young people often lose...
Chronic Kidney Disease and Clinical Outcomes in Patients With Multiple Myeloma: A Multicenter Real-World Cohort Study
This study followed people with multiple myeloma, a blood cancer, across several hospitals and compared those who also had chronic kidney disease. Myeloma often damages the...
Genetic Kidney Diseases: What to Know About Inherited Kidney Conditions
This is a plain-language guide from the National Kidney Foundation explaining inherited kidney conditions. It covers what genetic kidney disease is, the main types, what a risk...