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A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality

Key takeaways

Researchers found a pattern of proteins in the blood that tracks with allostatic load, which is the wear and tear the body takes from long-term stress. People with that protein pattern were more likely to have disease in several organ systems and more likely to die during follow-up. This is an observational study, so it shows a link, not proof that stress caused the illness. People who are already sick can have both higher stress and these protein changes.

Who did this work

Yufan Guan (University of Virginia) · Jie Shen (University of Virginia) · Li Li (University of Virginia) · Kai Zhang (University of North Texas) · Song Liu (Roswell Park Comprehensive Cancer Center) · Qianqian Zhu (Roswell Park Comprehensive Cancer Center) · Philip I. Chow (University of Virginia) · Hongmei Jiang (Northwestern University) · Jing Li (University of Alabama at Birmingham) · Lifang Hou (Northwestern University) · Hua Zhao (University of Virginia)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-10
https://doi.org/10.3390/proteomes14030047