← brief for 2026-09-11 · Slowing decline

Low baseline HbA1c and reduced eGFR are associated with relatively unfavorable body recomposition after SGLT2 inhibitor therapy in type 2 diabetes.

Key takeaways

In people with type 2 diabetes on SGLT2 inhibitors, those with lower blood sugar and worse kidney filtering rate (eGFR) at the start tended to lose more fat but also more muscle than others, which could matter for strength and recovery; this study shows a pattern, not cause-and-effect.

Who did this work

Gobaru M · Hasuzawa N · Kurinami N · Wada N · Wang L · Nagayama A · Ashida K · Moriyama Y · Jinnouchi H · Nomura M

Source

Article · PubMed, the drug frontier · 2026 Aug 27
https://pubmed.ncbi.nlm.nih.gov/42723833/