← brief for 2026-09-11 · Slowing decline

Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury

Paper D Peer reviewed Preclinical

Key takeaways

Apelin-13 is a small natural peptide. Giving it before cutting off and then restoring blood flow to the kidney reduced the scarring that followed in older animals. Scarring is what turns a one-time kidney injury into permanent loss of function, and older kidneys scar more. This was done in animals, not people, and the drug was given before the injury, which is rarely possible in real life.

Who did this work

Won-Seok Oh (Chungnam National University) · Sang Gon Lee (Chungnam National University) · H.-T. Kim (Korea Basic Science Institute) · Ji-Hyun Moon (Konyang University) · Ah-La Choi (Konyang University) · Seung Yun Han (Cheongju University) · Do Kyung Kim (Konyang University) · Nam Seob Lee (Konyang University) · Young Gil Jeong (Konyang University) · Geum-Lan Hong (Chungnam National University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-10
https://doi.org/10.3390/biomedicines14092033