Kidney research, 2026-08-31
Some common drugs may help protect kidneys in specific situations, but more research is needed
Today's findings focus on how existing medications—especially SGLT2 inhibitors—might influence kidney outcomes in special cases, though most evidence is observational and not definitive. A large Chinese study adds to the understanding of lifestyle and mental health factors in kidney disease risk, while another review points to systemic challenges in care delivery. Several reports describe rare or complex kidney issues where clear answers are still lacking.
Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases
This study tested urine for breakdown products of collagen type I to find a sign of scarring in diseases like kidney disease, but it was done only in test tubes and animals — not...
Anti-LCN2 antibody treatment is associated with attenuated hearing loss and blood–labyrinth barrier disruption in a mouse model of chronic kidney disease
In mice with kidney disease, an experimental antibody reduced hearing loss and protected a barrier in the inner ear. The study was done in animals only — no people were tested yet.
M4 drug discovery: Human drug predictions from integrated preclinical insights exemplified with a GLP-1R agonist.
This paper describes a method for predicting how a drug will behave in people using lab and animal data. The worked example is a GLP-1 medicine used for type 2 diabetes. It is...
Measurement-aware identification of 48-hour acute kidney injury persistence
This work tests a better way to tell whether sudden kidney injury has lasted past 48 hours. Sudden kidney injury (acute kidney injury, or AKI) is a fast drop in how well the...
PATHOMORPHOLOGICAL CHANGES IN THE KIDNEYS FOLLOWING ACUTE MYOCARDIAL INFARCTION: MECHANISMS OF ACUTE AND CHRONIC RENAL DAMAGE
This examines kidney tissue under a microscope after a heart attack to describe what damage appears. A heart attack can cut blood flow to the kidneys, and this work traces how that...
HISTOPATHOLOGICAL FEATURES OF RENAL TISSUE DAMAGE IN CARDIORENAL DYSFUNCTION AFTER MYOCARDIAL INFARCTION
This looks at kidney tissue damage under a microscope when the heart and kidneys both fail after a heart attack. It covers the same ground as another posting in today's batch from...
STRUCTURAL AND FUNCTIONAL RENAL ALTERATIONS IN THE POST-INFARCTION PERIOD: A PATHOMORPHOLOGICAL ANALYSIS
This describes changes in kidney structure and function in the period after a heart attack, based on tissue analysis. It repeats the same material as another posting in today's...
Integrating machine learning and GWAS for variant prioritization in the INCIPE cohort highlights ABC transporter genes in chronic kidney disease
Researchers studied the genes of people in a long-running Italian health study and used computer models to pick out which gene changes line up with chronic kidney disease. A family...
Machine Learning–Based Prediction of Hemoglobin Variability in Patients with Chronic Kidney Disease Receiving Erythropoiesis-Stimulating Agents: A Real-World Retrospective Study
Doctors built a computer model to predict swings in hemoglobin, the part of blood that carries oxygen, in people with kidney disease who take drugs that push the body to make more...
Sevelamer Carbonate
This is the official drug label for sevelamer carbonate, a pill that soaks up phosphorus from food in the gut so less gets into the blood. It is approved for adults and for...
Sex in CKD trials: representation and treatment effects of cardiorenoprotective therapies.
A review of 27 kidney trials found women made up less than half the participants, even though they have similar rates of disease. The study also showed that SGLT2 inhibitors and...
Efficacy and safety of henagliflozin in IgA nephropathy: A real-world observational study from China.
In 48 Chinese adults with IgA nephropathy, henagliflozin — a new SGLT2 inhibitor — lowered protein in the urine by about 35% after 12 weeks, and side effects were mild. This...
Cardiovascular outcome of glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitor on end-stage kidney disease patients with heart failure: an emulated target trial in patients with diabetes.
Using health records from over 12,000 dialysis patients with diabetes and heart failure, researchers compared those who started GLP-1 drugs to those who started DPP-4 inhibitors....
Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease.
In rats with kidney disease, a combo of the fish oil DHA and the blood pressure drug captopril reduced artery damage caused by a gut toxin. The study used 24 rats over eight weeks...
Life's Essential 8 Score and Cardiovascular-Kidney Outcomes in ASCVD: A UK Biobank Prospective Cohort Study.
People with heart disease who scored higher on a heart health checklist had lower chances of heart problems and kidney decline over time. This study tracked 10,000 people but...
Ruxolitinib prevents irreversible autoimmune endocrinopathies in APECED.
In two people with a rare genetic disorder that causes multiple autoimmune problems, a drug called ruxolitinib lowered inflammation and helped prevent hormone gland damage. This is...
Early Secondary Hyperparathyroidism and the Evolving Spectrum of Mineral and Bone Disorder in Chronic Kidney Disease: A Single-Centre Experience From Central India.
In 150 people with kidney disease in India, mineral and bone problems changed as their kidney function worsened. This type of study shows a link between stage of disease and...
Protein carbonyl: A sensitive marker reflecting oxidative stress in prevalent hemodialysis patients.
This study found higher levels of a protein marker called protein carbonyl in people on dialysis, and it linked those higher levels to worse nutrition. Because it only looked at...
Renal diseases and blood pressure dysregulation in acute care: Pathophysiology, clinical patterns.
This article explains how blood pressure problems happen in people with kidney disease and why they matter for diagnosis and outlook. It is a summary of existing knowledge, not a...
FcRn Upregulation Exacerbates Podocyte Injury via Insulin Resistance-Induced Autophagy Disorder in Diabetic Kidney Disease.
In mice with diabetic kidney disease, removing a protein called FcRn from kidney cells reduced scarring and improved insulin handling. This was not tested in people, so it is too...
Adynamic Bone Disease in Chronic Kidney Disease: From PTH Suppression-Driven Remodeling Phenotype to Osteoanabolic Therapy.
This review covers adynamic bone disease, where bone stops rebuilding itself in advanced kidney disease. The authors argue the main cause is treatment that pushes parathyroid...
Multimodal Detection of Subclinical Cardiovascular Disease in Chronic Kidney Disease.
Heart disease is the leading cause of death in people with chronic kidney disease, and this review explains why: inflammation, hardened and calcium-filled blood vessels, and waste...
Antiproteinuric Effect of SGLT2 Inhibitors in Patients With Hepatocellular Carcinoma Receiving Atezolizumab Plus Bevacizumab.
SGLT2 inhibitors are diabetes pills already known to cut protein in the urine, a sign of kidney damage. Doctors at several hospitals looked back at records of liver cancer patients...
Nintedanib-Associated Glomerular Endothelial Injury With Secondary Collapsing Focal Segmental Glomerulosclerosis: Potential Role of Sodium-Glucose Cotransporter 2 Inhibition.
Nintedanib is a drug for scarred lungs that rarely harms the kidneys, but a few patients have developed serious kidney problems on it. This report describes damage to the filters...
Global, regional and national burden of hypertension-associated chronic kidney disease attributable to high and low temperature from 1990 to 2021 and projections to 2050: a finding from the Global Burden of Disease Study 2021.
This study found that both hot and cold weather raises the risk of kidney disease linked to high blood pressure, especially in older adults — but because it looked at population...
Sex Differences in Incident Stage 3 Chronic Kidney Disease: A Narrative Review.
This review found that women and men develop stage 3 kidney disease at different rates, but studies disagree due to differences in age, race, and other factors — so it shows a...
7 Back-to-School Kidney-Friendly Recipes for Busy Families
The National Kidney Foundation published seven quick recipes for families whose child has kidney disease, aimed at busy school mornings, packed lunches, and fast dinners. The point...
Influence of periodontal conditions on quality of life in patients with chronic kidney disease: A systematic review and meta-analysis.
A review of many studies found that people with kidney disease who have gum disease report worse quality of life — including more pain, trouble eating, and social embarrassment —...
Dietary Patterns and Kidney Health: An Umbrella Review of Systematic Reviews and Meta-Analyses.
An umbrella review of 27 systematic reviews found that eating more fruits, vegetables, whole grains, and fish is linked to slower kidney decline, while high salt, processed meat,...
Joint effects of physical activity and depressive symptoms on chronic kidney disease risk: Findings from the CHARLS cohort.
In over 10,000 middle-aged and older Chinese adults followed for seven years, people who were inactive and had depression symptoms were more likely to develop chronic kidney...
Dukungan Sosial dan Persepsi Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Selama Hemodialisa
This Indonesian study asked whether social support and how patients view their illness are tied to quality of life for people on dialysis. Social support means practical and...
Sleep Quality, Daytime Sleepiness, and Circadian Rhythm Characteristics in Chronic Kidney Disease: A Cross-Sectional Study Across Disease Stages.
Among 344 adults with kidney disease in Turkey, sleep quality and timing of the body’s clock differed by how advanced their kidney disease was. This study shows a link between...
Occupational Therapy Services Provided to Adults Diagnosed With Kidney Disease: A Scoping Review.
This review looked at how occupational therapists help adults with kidney disease stay independent and manage daily life, but it did not report any new study results — only a...
Mini-track, Mini-nephroscopy, Mini-ultrasonic Probe Percutaneous Nephrolithotomy versus Standard Percutaneous Nephrolithotomy for Renal and Proximal Ureteral Stones: A Prospective Cohort Study
This compares two versions of keyhole surgery to remove kidney stones, one using smaller instruments than the standard tools. Patients were followed forward in time but were not...
Podocyte injury damages podocytes in chimeric organoids.
In test-tube kidney organoids made from mouse cells, damaging some filtering cells caused nearby healthy ones to get hurt too — even without direct contact. This suggests a signal...
Crotonylome profiling identifies MLKL crotonylation in lupus nephritis associated with RAB1A-mTOR signalling and autophagy changes in tubular epithelial cells.
Lupus can attack the kidneys, a condition called lupus nephritis. Researchers compared blood cells and kidney biopsy tissue from people with lupus nephritis, people with lupus but...
Cardio-renal protection of MRAs in kidney-transplanted diabetic patients.
This is a review of a drug family called MRAs for people who have had a kidney transplant and also have diabetes. Transplanted kidneys often scar and slowly lose function over the...
Rad the latest summaries from the ISN Journal portfolio - International Society of Nephrology
A kidney journal roundup describes one child with C3 glomerulopathy, a rare disease where the immune system damages the kidney's filters. This disease often comes back in the new...
The burden on caregivers of patients undergoing hemodialysis in a tertiary care center
This study measured the strain on family members caring for people on dialysis at one large hospital. Caregiver burden means the time, money, and emotional load carried by the...
Comprehensive Protein Profiling of Kidney Cancer to Advance Precision Oncology
Researchers mapped the proteins found in kidney cancer tissue to help match patients to targeted drugs. Proteins are the working parts of cells, and their pattern can hint at which...
Eight editions of kidney stories on camera: bringing lived experience into global focus - International Society of Nephrology
The International Society of Nephrology is asking for short films about living with kidney disease, now in its eighth year since 2019. Past films followed patients and families...
Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study.
Children who got ifosfamide chemotherapy were more likely to develop chronic kidney disease within five years, based on a group of 127 kids in the Netherlands. This study shows a...
Chronic Kidney Disease Care in Saudi Arabia: Challenges, and Future Directions Under Vision 2030 (A Systematic Review Study).
Researchers gathered published studies on kidney disease in Saudi Arabia to see how big the problem is and where care falls short. Diabetes and high blood pressure came up as the...