← brief for 2026-08-31 · Slowing decline

FcRn Upregulation Exacerbates Podocyte Injury via Insulin Resistance-Induced Autophagy Disorder in Diabetic Kidney Disease.

Key takeaways

In mice with diabetic kidney disease, removing a protein called FcRn from kidney cells reduced scarring and improved insulin handling. This was not tested in people, so it is too early to know if this would help humans.

Who did this work

Ai S (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.) · Ding Y (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.) · Zhang C (Department of Nephrology, Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei Province, China.) · Li Z (Department of Nephrology, Beijing Hospital, Beijing, China.) · Yang Y (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.) · Sun X (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.) · Ma M (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.) · Wang Y (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.) · Luo P (Department of Nephrology, Clinic College of Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai Province, China.)

Source

Paper · Europe PMC, CKD · 2026-09-01
https://doi.org/10.2337/db26-0008