← brief for 2026-08-31 · Regeneration & devices

Crotonylome profiling identifies MLKL crotonylation in lupus nephritis associated with RAB1A-mTOR signalling and autophagy changes in tubular epithelial cells.

Key takeaways

Lupus can attack the kidneys, a condition called lupus nephritis. Researchers compared blood cells and kidney biopsy tissue from people with lupus nephritis, people with lupus but no kidney involvement, and healthy people. They found a chemical tag on a protein called MLKL that tracked with kidney scarring and with a broken cell cleanup system in the kidney's filtering tubes. This is laboratory work on samples and cells, not a treatment tested in patients, so it points at a possible target and nothing more.

Who did this work

Lu RL · Meng SH · Peng QZ · Chen Y · Yang X · Liu HY · Zheng FP · Liu D · Hong X

Source

Article · PubMed, fibrosis reversal · 2026 Aug 31
https://pubmed.ncbi.nlm.nih.gov/42674810/