← brief for 2026-08-31 · Slowing decline

Antiproteinuric Effect of SGLT2 Inhibitors in Patients With Hepatocellular Carcinoma Receiving Atezolizumab Plus Bevacizumab.

Article C Peer reviewed Observational

Key takeaways

SGLT2 inhibitors are diabetes pills already known to cut protein in the urine, a sign of kidney damage. Doctors at several hospitals looked back at records of liver cancer patients given bevacizumab, a cancer drug that often causes protein to leak into the urine, to see whether being on an SGLT2 inhibitor kept that leak down. This is a look back at existing charts, so it can show a link but cannot prove the drug caused the benefit. Patients on these pills may differ from those not on them in ways that also affect the kidneys.

Who did this work

Hori T · Yamamoto K · Aoi H · Koizumi Y · Kuromatsu M · Fukui A · Okamoto H · Hirata A · Shinmori K · Imanaka Y · Namba M · Kitamura S

Source

Article · PubMed, the drug frontier · 2026 Sep
https://pubmed.ncbi.nlm.nih.gov/42674726/