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M4 drug discovery: Human drug predictions from integrated preclinical insights exemplified with a GLP-1R agonist.

Article No results yet Peer reviewed

Key takeaways

This paper describes a method for predicting how a drug will behave in people using lab and animal data. The worked example is a GLP-1 medicine used for type 2 diabetes. It is about how drug developers make predictions, not about kidney disease, and it reports no patient results. Off-topic for this digest.

Who did this work

Silfvergren O · Rigal S · Schimek K · Simonsson C · Kanebratt KP · Forschler F · Yesildag B · Marx U · Vilén L · Gennemark P · Cedersund G

Source

Article · PubMed, the drug frontier · 2026 Aug 30
https://pubmed.ncbi.nlm.nih.gov/42669385/