← brief for 2026-08-31 · Slowing decline

Nintedanib-Associated Glomerular Endothelial Injury With Secondary Collapsing Focal Segmental Glomerulosclerosis: Potential Role of Sodium-Glucose Cotransporter 2 Inhibition.

Article C Peer reviewed Observational

Key takeaways

Nintedanib is a drug for scarred lungs that rarely harms the kidneys, but a few patients have developed serious kidney problems on it. This report describes damage to the filters inside the kidney, including a severe scarring pattern called collapsing FSGS, and discusses whether an SGLT2 inhibitor helped or played a role. It is a report on individual patients, so it shows what happened in a handful of cases, not what the drug does in general. Doctors still have no agreed way to manage this problem.

Who did this work

Furuto Y · Hashimoto H · Yoshino D · Ikeda S · Namikawa A · Sato D · Takahashi H · Morikawa T · Shibuya Y

Source

Article · PubMed, the drug frontier · 2026 Sep
https://pubmed.ncbi.nlm.nih.gov/42674550/