Kidney research, 2026-10-20
New data shows some people respond better to diabetes drugs.
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A large review found that high-intensity interval training is the best exercise for lowering blood fats.
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A UK study linked high blood pressure and metabolic markers to the start of kidney disease.
Today's news focuses on how to manage diabetes and blood pressure to protect kidney health. One study looks at how different people react to diabetes medications. Other reviews highlight the benefits of specific exercise types and the risks of high blood pressure.
Evaluation of Clinical Outcomes of Selective Versus Nonselective Beta-Blockers Among Patients With Heart Failure With Reduced Ejection Fraction Receiving Sacubitril/Valsartan.
This study compared two types of heart failure drugs in patients also taking a specific blood pressure medicine. It is a retrospective review, so it shows a link between drug...
Warfarin for Left Ventricular Thrombus in Nonischemic Cardiomyopathy With Acute Kidney Injury: A Case Report and Literature Review of Anticoagulation Strategies in Renal Impairment.
This report describes one patient who had a heart clot and kidney injury. It reviews how doctors choose blood thinners for people with weak kidneys. It is a single case, not a...
Betaine alleviates renal osteodystrophy by stabilizing ABCG1 mRNA to inhibit HMOX1-mediated ferroptosis in BMSCs.
This study tested if betaine, a nutrient, helps protect bones in people with kidney disease. The main tests were done on bone cells in the lab. This work was done in cells, not in...
Sodium-glucose cotransporter 2 inhibitors in patients with systemic lupus erythematosus and lupus nephritis: A systematic review and meta-analysis.
This review combined data from many trials to check if SGLT2 drugs help people with lupus nephritis. These drugs lower blood sugar and protect kidneys. The analysis looked at how...
Effectiveness of Weekly Semaglutide Treatment (0.5 or 1 mg) in Chilean Patients with Type 2 Diabetes Mellitus.
A study of 104 people with type 2 diabetes tested a weekly injection of semaglutide. The drug is used to lower blood sugar and protect organs. The treatment lasted 24 weeks,...
Finerenone: A Non-Steroidal Mineralocorticoid Receptor Antagonist and Its Emerging Role in Cardiovascular-Kidney-Metabolic Syndrome.
This article explains how finerenone works to protect the heart and kidneys. It blocks a hormone receptor that causes inflammation and scarring. The text reviews large studies but...
Oral Semaglutide and the Kidney: Promise, Limitations, and the Road Ahead.
This is a letter to the editor about a weight-loss drug called semaglutide. It discusses the promise and limits of using this drug for kidney disease. There are no new clinical...
The Chronic Renal Insufficiency Cohort (CRIC) study measured hepcidin, cardiovascular, kidney and metabolic outcomes in chronic kidney disease
This study used data from the CRIC cohort to look at a protein called hepcidin in people with chronic kidney disease. It is an observational study, so it shows a link, not proof of...
Clinicopathologic and Outcome Characteristics of Glomerulopathy With Striated Deposits: A Case Series
This is a small report on a very rare kidney disease. It describes a few patients to help doctors understand the condition. It is a case series, so it shows what happened in these...
Peritoneal dialysis induces hepatic metabolic stress as an instigator for systemic inflammation
This article discusses how the sugar used in peritoneal dialysis might affect the liver. It is a journal page, not a full study with results. It explores a possible link between...
A study using the REIN registry suggests a statin therapy benefits for secondary prevention in patients receiving dialysis
This article looks at whether statins help people on dialysis who have already had a heart event. It is a journal page, not a full study with results. It discusses a possible...
Safety outcomes of semaglutide by chronic kidney disease severity in the FLOW trial
This article looks at the safety of semaglutide in people with kidney disease. It is a journal page, not a full study with results. It discusses a possible safety profile, but...
Oxidative Stress Potentiates a STAT1–APOL1 Feedforward Loop and Governs Disease Severity in APOL1-Mediated Kidney Disease
This item is a journal page from Kidney International. It has no abstract, so we have not read the study. There are no results to report yet.
in this issue
This is a news page about a study on kidney cysts. It mentions a new scan method to spot early changes. There are no new results in this specific item.
The macrophage paradox in renal AL amyloidosis: lessons from histology and imaging
This is a news page about a study on a rare kidney disease. It says that certain immune cells in the kidney can predict damage. There are no new results in this specific item.
Gut-targeted interventions to complement PTH-lowering therapy
This is a news page about a study in rats. It says a gut fiber helped bones in animals with kidney disease. There are no new results in this specific item.
Fingerprinting the polycystic kidney: radiomics of the noncystic parenchyma for earlier ADPKD detection
This is a short comment on a pilot study about polycystic kidney disease. The study used special scans to look for early tissue changes. The comment discusses the findings but does...
Corrigendum to “Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts.” Kidney International 2026;109:1221–1238
This is a correction to a previous paper. The authors fixed a mistake in a supporting table. The table had some data mixed up by accident. There are no new results in this piece.
The Case | A man with kidney failure and an unusual abdominal CT scan
This is a case report about one man with kidney failure. He had a very high creatinine level, which is a waste product in the blood. The report describes his symptoms and scans. It...
The Case | Pulmonary nodules and acute kidney injury
This is a case report about a man with sudden kidney injury. He also had spots in his lungs. The report describes his medical history and tests. It is a single story, not a study...
Fetal growth restriction and lifelong risk of acute kidney injury: advancing the developmental origins of kidney disease
This is a short comment on a study about babies who were small at birth. The study found these people have a higher risk of sudden kidney injury later in life. The comment...
Estimating GFR: what it is, what it is not, and why prediction cannot settle the question
This is a short comment on how we estimate kidney function. It argues that one way of calculating the number is not perfect. The authors say the method needs more testing over...
Abnormal ER-Golgi vesicular trafficking leads to podocyte detachment
This is a short comment on a study about kidney cells. The study looked at how cells lose their grip in the kidney filter. The comment discusses the findings but does not report...
Corrigendum to “Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis.” Kidney International 2023;103,565–579
This is a correction to a previous paper. The authors added back some missing data in a supporting table. The data had been deleted by accident. There are no new results in this...
Urinary Metabolites in Tryptophan-Kynurenine Pathway and Risk of CKD Progression in Patients With Type 2 Diabetes
This study looked at urine samples from people with type 2 diabetes. It found a link between certain chemicals in the urine and faster kidney decline. This shows a connection, but...
SPYRAL GEMINI Pilot Study
This is a planned study to test a new device that uses energy to calm nerves. The goal is to see if it is safe and lowers blood pressure. There are no results yet.
Real-world observational study evaluating metabolic and kidney outcomes in patients living with chronic kidney disease and type 2 diabetes mellitus with obesity prescribed tirzepatide.
This study followed 62 adults with kidney disease and type 2 diabetes who started a weight-loss drug called tirzepatide. It is an observational study, which means it shows a link...
Incidence and Risk Factors of Contrast-Associated Acute Kidney Injury Following Contrast-Enhanced CT: A Retrospective Study
This retrospective study looked at records of people who had CT scans with dye. It aimed to find how often the dye caused sudden kidney injury and who was at risk. It shows links...
Is SGLT2 inhibitor therapy recommended for patients with diabetes and chronic kidney disease classified as G3aA1?
This item discusses a common kidney drug for people with diabetes. It is a record on a data repository, not a new study with results. There are no new findings to report here.
Distinct Molecular Relationships and Partial Pathway Convergence of Anserine and RRR-α-Tocopherol in Human Diabetic Kidney Disease
This study looked at 36 human kidney samples to find links between certain molecules and diabetic kidney disease. It shows a connection, but it is not proof that these molecules...
Screening for Early Diabetic Kidney Disease: How the Urinary Albumin-to-Creatinine Ratio (UACR) Performs in Newly Diagnosed Type 2 Diabetes
This article explains how a simple urine test can find early kidney damage in people with diabetes. It is a review of existing knowledge, not a new study with new results.
Longitudinal kidney outcomes and safety after finerenone initiation in patients with non-diabetic chronic kidney disease: a single-center retrospective cohort study
This study followed people with kidney disease who started a drug called finerenone. It looked at how their urine protein levels changed over time. This shows a link in real-world...
RISK FACTORS FOR CHRONIC GLOMERULONEPHRITIS IN CHILDREN
This study looked at risk factors for a type of kidney inflammation in children. It found that several risks often appear together. The authors note the results need more checking...
Ultrasound-detected renal surface nodularity and renal damage in hypertensive adults undergoing routine health screening: a cross-sectional study
Researchers looked at ultrasound images of 871 adults with high blood pressure. They found that bumpy kidney surfaces were linked to signs of kidney damage. This shows a link, not...
Atherogenic Index Of Plasma As An Early Marker Of Diabetic Kidney Disease In Type 2 Diabetes Mellitus at RLJ Hospital, Kolar
This study checked if a blood test called the atherogenic index of plasma can spot early kidney damage in people with type 2 diabetes. It is a cross-sectional study, which means it...
Prevalence and Predictors of Blood Pressure Control in Pre-dialysis Chronic Kidney Disease Patients in Calabar, South-South Nigeria: A Hospital-Based Cross-Sectional Study.
This study looked at 59 people with kidney disease who were not yet on dialysis. It checked how many had their blood pressure under control. It is a cross-sectional study, so it...
Frailty transitions and the risk of multisystem burden of chronic disease: a prospective cohort study in China.
This study followed 17,708 adults in China to see how frailty changes affect the risk of chronic diseases. It is a prospective cohort study, which means it followed people over...
Digital self-management application for patients undergoing hemodialysis: influences on health awareness and frailty.
This pilot study had 12 people on dialysis use a health app for 3 months. It is a single-group observational study, so it shows a link, not proof of cause. It suggests the app may...
Real-world renoprotective effects of polyethylene glycol-loxenatide in type 2 diabetes: a multicenter, ambispective cohort study.
This large study followed 3,305 people with type 2 diabetes and kidney issues. It looked at a drug called polyethylene glycol-loxenatide. It is a cohort study, so it shows a link,...
Hepatic steatosis and liver stiffness in patients with gout: a controlled cross-sectional elastography study
This study looks at liver health in people with gout. It is a cross-sectional study. There is no abstract available, so we do not have the specific results yet.
Time to treatment intensification in type 2 diabetes mellitus: factors associated with timing in a resource-constrained setting
This study looked at 403 people with type 2 diabetes in Ethiopia. It checked how long it took to adjust their treatment. It is a retrospective cohort study, so it shows a link, not...
Elevated human epididymis protein 4 levels in chronic kidney disease compromise the accuracy of the risk of ovarian malignancy algorithm
A test called ROMA helps doctors check for ovarian cancer. This study found that kidney disease can make the test less accurate. It shows a link between kidney issues and test...
When Lupus Isn't to Blame: Disseminated Tuberculosis Masquerading as Disease Flare in Lupus Nephritis
This is a report on one patient. The patient had lupus and a kidney infection. The doctors found the infection was actually tuberculosis. This is a single case, so it does not show...
SGLT2 Inhibitors Beyond Glycemic Control: Emerging Therapeutic Applications, Clinical Evidence, Safety and Future Perspectives
This is a review of a drug called SGLT2 inhibitors. It talks about how the drug helps the heart and kidneys. This item is a preprint, so it has not passed peer review yet. There...
The Limits of the Dichotomy Between Responders and Nonresponders in Chronic Kidney Disease
This article argues that labeling patients as 'responders' or 'nonresponders' is too simple. It says doctors should look at the whole picture. This is an opinion piece, so it has...
Association Between the Modified Renal Angina Index and Major Adverse Kidney Events at 90 Days in Critically Ill Adults: A Retrospective Cohort Study
This study looked at 250 people in the ICU. It checked if a score called mRAI could predict kidney trouble. It shows a link between the score and kidney events, but it is not proof...
Extreme Nephrotic-Range Proteinuria in Mixed Lupus Nephritis with Low Histologic Activity. Potential Contribution of Obesity-Related Hyperfiltration in a Triple Autoimmune Overlap Syndrome
This report describes one man with three rare immune diseases. He had a lot of protein in his urine, but his kidney tissue looked mostly normal. The doctors think his weight may...
NLR–TyG index and prevalent chronic kidney disease in hypertension: a cross-population study
This study looked at blood test scores that show body stress and sugar issues. It found a link between high scores and kidney disease in people with high blood pressure. This shows...
An Italian Delphi consensus on the epidemiology, characteristics, and management of C3 glomerulopathy
A group of kidney doctors in Italy met to agree on how to treat a rare kidney disease called C3 glomerulopathy. They shared their views to create a set of guidelines. This is a...
The pharmacokinetics of a single intravenous dose of difelikefalin in adolescents aged 12 to 17 years on hemodialysis
This small study gave a single dose of a scratch-control drug to teens on dialysis. It tracked how the drug moved through their bodies over three days. The goal was to check safety...
Stage-specific associations of nutrition-related surrogate insulin resistance indices across the chronic kidney disease continuum: evidence from a Chinese cohort
This study followed a group of people to see if blood sugar scores linked to kidney decline. It found that higher scores were associated with faster loss of kidney function. This...
Reliability of Spot Urine Protein-to-Creatinine and Urine Albumin-to-Creatinine Ratios in Acute Kidney Injury: A Cohort Study
This study checked if quick urine tests are accurate when kidneys are suddenly injured. It compared these tests to standard 24-hour urine collections. It is an observational study,...
Incident Type 2 Diabetes in Individuals With CKD: The REGARDS Study.
This study followed 7,511 people for 10 years. It found that people with kidney disease had a higher chance of developing type 2 diabetes. It is an observational study, so it shows...
Exploring heterogeneous treatment effects for GLP-1 receptor agonists in patients with type 2 diabetes.
This study looked at how different people respond to GLP-1 drugs for type 2 diabetes. It found that some people get much better results than others. The study uses data from past...
AI-Guided Identification of a Covalent SMAD3 Regulatory Mechanism of Celastrol in Diabetic Kidney Disease.
This study used AI to find how a drug called Celastrol works in diabetic kidney disease. It showed that the drug binds to a protein called SMAD3 in the lab. This was done in cells...
Sleep Disturbances in Chronic Kidney Disease - The CKD-REIN Cohort Study.
A large study of 2,765 people found that sleep problems in kidney disease are linked to many factors. These include medical symptoms, social issues, and lifestyle habits. This...
Impact of Nutrition Education and Low-Protein Dietary Interventions on the Incidence and Progression of Chronic Kidney Disease.
This review looked at many studies on low-protein diets and kidney disease. It found that eating less animal protein and more plants can slow the decline of kidney function. This...
Phytodiab® in subjects with metabolic syndrome and early type 2 diabetes: a 12-week observational registry study.
Sixty adults with early diabetes took a plant-based supplement for 12 weeks. The group taking it lost a bit more weight than the group that only changed their diet. This is an...
Kidney stone disease: to drink or not to drink—that is the question
This is a news page about a large trial on kidney stones. It says that a plan to drink more water did not stop stones from coming back. There are no new results in this specific...
Effect of individual and group-based dietitian-delivered education interventions on outcomes for people with chronic kidney disease stages 3a-5: A systematic review and meta-analysis.
This large review combined data from many studies on dietitian-led nutrition education. It looked at people with stage 3 to 5 kidney disease. The review found that getting help...
https://www.kidney.org/news-stories/8-things-you-probably-didn-t-know-could-affect-your-kidney-health
This article from the National Kidney Foundation lists eight common habits that can impact kidney health. It covers topics like diet, exercise, and medication use. The page is an...
Evaluation of Depression Screening Methods Administered by Registered Nurses in Chronic Hemodialysis Patients
This study is starting to test how nurses can check for depression in people on dialysis. It aims to find the best way to spot mood issues early. There are no results yet.
Hubungan Kecerdasan Spiritual dengan Tingkat Kecemasan Pasien Gagal Ginjal Kronik yang Menjalani Terapi Hemodialisa
This study looked at 427 people on dialysis in Indonesia. It found a link between spiritual intelligence and lower anxiety levels. This is an observational study, so it shows a...
Distinct viability and oxygen-sensing responses to hypoxia and reoxygenation in pancreatic islets
This study looked at how low oxygen affects islets, which are cells that make insulin. The researchers tested rat islets in the lab. This work was done in animals, not in people...
Structural modelling predicts that fibrocystin destabilisation is a pathogenic cause of ARPKD
Researchers used computer models to study a protein called fibrocystin. They looked at how gene changes make this protein unstable. This work was done in computer simulations, not...
Are we ready for the widespread application of transcutaneous measurement of the glomerular filtration rate?
This is a short comment on a new way to measure kidney function. It looks at a method that uses a skin patch instead of a blood test. The authors say the method is promising but...
A Human Precision Cut Kidney Slice Platform for Studying Glomerular Biology and Therapeutic Responses
Researchers used thin slices of human kidney tissue to test how cells react to a drug. This is a lab method, not a test in people yet. It helps scientists study kidney disease in a...
Flexible Ureteroscopy in Complex Renal Stone Disease: A Retrospective Cohort Study
This study looked at 59 people with kidney stones in unusual kidney shapes. Doctors used a flexible scope to remove the stones. The study shows a link between this method and stone...
Mesenchymal stem cell-derived extracellular vesicles in diabetes: immunomodulation and therapeutic prospects
This review looks at small bubbles released by stem cells. These bubbles can carry messages that help calm the immune system. The review says these bubbles may protect the body in...
From the Gut to the Kidneys: How Biomarkers Are Shaping IgAN Management
This is a 50-minute video where experts discuss how the gut affects a specific kidney disease called IgA nephropathy. It is a discussion for doctors, not a new study with results.
Prescribing patterns and impact of glucagon-like peptide-1 receptor agonists in a kidney transplant evaluation cohort in British Columbia, Canada A single-center experience.
This study looked at 2,789 people being evaluated for a kidney transplant. It is a retrospective review, so it shows a link, not proof of cause. The doctors tracked how many people...
Microvascular inflammation in kidney transplants: finally an effective treatment?
This is a news page about a study on kidney transplants. It says a new drug target may help treat a type of rejection. There are no new results in this specific item.
What is the impact of a donor's pre-donation GFR on the recipient's kidney function at 1 year post-transplant?
This review looked at whether a donor's kidney filtering rate before surgery affects the new kidney's function one year later. It found no direct proof of a link, though indirect...
https://ir.unither.com/press-releases/2026/10-20-2026-120017904
A company opened a new building to make animal kidneys for transplant. This is a business update about their production capacity. There are no new medical trial results in this...
ASSISTÊNCIA DE ENFERMAGEM NA PREVENÇÃO E MANEJO DA INJÚRIA RENAL AGUDA: REVISÃO DE ESCOPO
This is a scope review that maps how nurses help prevent and manage sudden kidney injury in hospitalized adults. It summarizes existing knowledge rather than reporting new trial...
PERFIL EPIDEMIOLÓGICO DA DOENÇA RENAL CRÔNICA EM ESTÁGIO TERMINAL NO BRASIL
This report looks at kidney failure in Brazil. It describes who gets the disease and why. It notes that aging and common health issues like diabetes are driving the rise. There are...
Misdiagnosed Failure in Home Dialysis Adoption: A Call for Clinical Accountability
This article looks at why some people do not start home dialysis. It calls for better care from doctors. There is no abstract, so we cannot confirm the specific details of the...
Anemia and Red-Cell Size Across Estimated Glomerular Filtration Rate in a Hospital Laboratory Cohort
This study checked blood records for 37,831 adults in a hospital. It found that low blood counts are very common in people with lower kidney function. This shows a link, but it...
Authors' Reply: Eligibility for Predialysis Care and Effect on Patient Outcomes in Ontario Needs Further Study
This is a short reply from the authors of a previous study. It discusses who gets care before starting dialysis. There are no new results in this reply.
Prevalence and Population Burden of Cardiovascular–Kidney–Metabolic Syndrome Stages Among Mexican Adults: A Nationally Representative Cross-Sectional Study
This is a preprint about how common heart and kidney problems are in Mexico. It is not yet published in a journal. There is no abstract, so we cannot confirm the specific findings.
Delayed sequential lung, acral cutaneous and brain metastases after radical nephrectomy for clear cell renal cell carcinoma: a case report
This is a report on one man who had kidney cancer spread to his lungs, skin, and brain after surgery. It describes his specific case but does not provide new results for other...
Malignant Renal Mass: Pathogenesis & clinical findings
This is a guide about kidney cancer. It explains how the disease works and what signs to look for. There are no new study results in this item.
Malignant Renal Mass: Pathogenesis and clinical findings
This article is a guide to kidney cancer. It explains how the disease starts and what signs to look for. There are no new study results in this text.
Artificial Intelligence in Polypharmacy. Moving Beyond Drug Alerts Toward Patient-Specific Medication Safety
This article discusses using computer programs to help doctors manage many medicines at once. It focuses on keeping patients safe when they take several drugs for different...