← brief for 2026-10-20 · Slowing decline

AI-Guided Identification of a Covalent SMAD3 Regulatory Mechanism of Celastrol in Diabetic Kidney Disease.

Article D Peer reviewed Preclinical

Key takeaways

This study used AI to find how a drug called Celastrol works in diabetic kidney disease. It showed that the drug binds to a protein called SMAD3 in the lab. This was done in cells and animals, not people yet. It suggests the drug could help slow kidney scarring, but more testing is needed.

Who did this work

Chen P · Deng H · Wang W · Gao L · Xiang G · Lang J · Qin Y · Geng Z · Zhang T · Zhou X · Shi M · Wang Y

Source

Article · PubMed, CKD progression and prevention · 2026 Oct 20
https://pubmed.ncbi.nlm.nih.gov/42901337/