Kidney research, 2026-09-24
New reviews confirm that certain diabetes drugs protect your kidneys and heart.
Today's news focuses on the strong evidence for using diabetes medications to protect kidney and heart health. The Mediterranean diet also remains a key recommendation for overall health. While some studies on patient readiness and quality of life were published, they show connections rather than proven causes.
Podocyte Vps34 deficiency drives early-onset glomerulopathy and mesangial IgA-dominant immune-complex deposition: a novel mouse model linking vesicular trafficking to glomerular immune dysregulation.
This study used mice to look at how a specific gene affects kidney function. When the gene was missing, the mice developed kidney damage and immune issues. This was done in...
Follow-up of congenital abnormalities of the kidney and urinary tract from the antenatal period to the first year of life: a retrospective study from Turkey.
This study followed 55 babies born with kidney abnormalities. It tracked their kidney function during their first year of life. It shows a link between birth defects and later...
Cardiovascular–kidney–metabolic syndrome as a mitochondrial systems disorder
This review suggests that heart, kidney, and metabolic problems share a common root. It points to issues with cell energy production. This view may help guide future treatments for...
An integrated single-cell atlas of hypertension
This article maps how high blood pressure affects cells. It is a review of existing data, not a new trial. It helps doctors understand the biology behind high blood pressure and...
FGF23 –Klotho Axis Dysregulation in Type 4 Cardiorenal Syndrome: Molecular Mechanisms, Paediatric Perspectives, and Emerging Therapeutic Targets
This review explains how a hormone system called FGF23 affects the heart in children with long-term kidney disease. It looks at how this system breaks down and what new drugs might...
Gut microbiome diversity, genus-level variation, and associations with clinical features in critically ill patients
This study looked at the gut bacteria of people in the ICU. It checked if changes in bacteria were linked to kidney disease. It found some links, but this is an observational...
Compartment-Specific Distribution of CD68-Positive Macrophages and its Association with Chronic Kidney Injury Across Diverse Renal Disorders
This study looked at 80 kidney biopsies from people with different diseases. It checked where immune cells were located in the kidney tissue. It found that these cells are linked...
Early adjunctive vasopressin was not associated with a lower 7-day risk of renal replacement therapy in norepinephrine-treated patients with cirrhosis: a target-trial-informed study with external replication
This study looked at patients with liver disease who were in the ICU. It checked if adding a blood pressure drug early helped protect their kidneys. It found no benefit. This is an...
Multi-omics integration identifies Acsm2/ACSM2A deficiency as a metabolic driver of ZBP1-mediated PANoptosis in acute kidney injury
This study looked at how kidney cells die during sudden injury. It found that a lack of a specific enzyme can trigger a type of cell death. The research was done in mice and cells,...
The guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse
Researchers found a gene called RINL that helps kidneys remove uric acid. When this gene does not work right, uric acid builds up in the blood. This study used human cells and mice...
A Microfluidic Electrochemical Immunosensor for Point‐of‐Care Testing of Cystatin C in Human Serum
Scientists built a small device to test for cystatin C in blood. Cystatin C is a marker for kidney function. This was a lab test of the device itself. It is not a study of how the...
Multicenter screening of childhood Fabry disease in Shandong Province, China
Researchers screened 920 children in China for Fabry disease, a rare condition that can hurt kidneys. They found 14 children had the disease. This shows that early screening can...
Gut Dysbiosis, Uremic Toxins, and NLRP3 Signaling in Chronic Kidney Disease: From Mechanistic Evidence to Clinical Biomarker Evaluation
This review connects gut health to kidney disease. It looks at how changes in gut bacteria can lead to inflammation. The paper summarizes existing research on this link. It does...
Beyond Creatinine: D-Amino Acids as Emerging Indicators of Kidney Function and Disease
This review looks at D-amino acids as a possible new way to check kidney health. Current tests like creatinine can be thrown off by muscle mass or age. This paper summarizes what...
Evaluating the Impact of Leukotriene Receptor Antagonists on Postoperative Acute Kidney Injury: A Retrospective Study
This study checked if a common allergy drug could protect kidneys after surgery. It looked at past records from one hospital. This shows a link between the drug and kidney injury,...
Cardiovascular–Kidney–Metabolic Overlaps, Clinical Outcomes, and Medications Among Patients With Heart Failure: Results From the Chinese Cardiovascular Association Database–Heart Failure Center Registry
This study looked at people with heart failure who also had kidney or diabetes issues. It found that having more of these conditions was linked to worse outcomes. This shows a...
IL-17A Mediates Cardiac Hypertrophy in Chronic Kidney Disease through the IL-23/Th17 Axis.
This study used mice to look at how kidney disease affects the heart. It found that a specific immune signal may cause heart muscle to thicken. This was done in animals, not people...
Prediction Utility of Urinary Albumin-Creatinine vs Protein-Creatinine Ratios in Chronic Kidney Disease
This study compared two urine tests to see which one better predicts kidney failure. It looked at people with chronic kidney disease. This shows a link between the test results and...
Tolerance of methotrexate co-administered with pegloticase in patients with uncontrolled gout: overview of the findings from the mirror RCT
This is a data summary from a trial on gout treatment. It looks at the safety of combining two drugs. It is not a peer-reviewed journal article. There are no new primary results to...
Insulin resistance, metabolic phenotypes, and the obesity paradox: a triglyceride glucose-body mass index framework in partial kidney diseases
This review looked at how a simple blood test score links to kidney disease. The score combines fat and sugar levels in the blood. It shows a link, but not proof of cause. The...
Clinical Evidence of Kidney Protection Exerted by SGLT2 Inhibitors.
This review looks at many large trials of a drug called SGLT2 inhibitors. It found that these drugs slow the decline of kidney function. They also lower the risk of needing...
Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases.
This study found a common marker in the urine of people with scarring in their organs. It looked at patients with liver, kidney, and heart disease. This shows a link between the...
The efficacy of Cordyceps sinensis preparations in improving kidney outcomes among patients with AKI during hemorrhagic fever with renal syndrome: evidence from a Chinese cohort.
This study looked at 99 people who had a sudden drop in kidney function. It found that about 27% of them went on to have long-term kidney disease. This shows a link between the...
Diurnal BP Patterns in Those at Increased Risk of CVD
This study is looking at how blood pressure changes during the day and night. It focuses on people at high risk for heart disease. There are no results yet because the study is...
DIALysis With EXpanded Solute Removal
This trial is starting to test a new type of dialysis. It aims to see if this method lowers the risk of death. There are no results yet because the study is just beginning.
Impact of fluconazole in vasopressin 2 receptor-related congenital arginine vasopressin resistance
This study tests a common anti-fungal drug in people with a rare kidney disorder. The condition causes the body to make too much urine. The text cuts off before it shares the...
Multiorgan protective therapy for CKM syndrome: the role of GLP-1-based therapies and SGLT2 inhibitors.
This review looks at two new drug types for diabetes. It found that these drugs protect the heart and kidneys. The review cites large studies that show these benefits. This is a...
The Intertwined Threat: How Diabetes Impacts Neurological Disorders - A Review Article.
This review looks at how diabetes affects the brain and nerves. It found that diabetes can cause stroke and other nerve damage. The review cites large studies that show these...
Localized Multidrug-Resistant Morganella morganii Urinary Tract Infection in a Dapagliflozin-Treated Man with Bladder Outlet Obstruction and Incomplete Ureteral Duplication: A Case Report.
This report describes one man who got a urine infection. He was taking a diabetes drug called dapagliflozin. The report shares his case, but it is a single story. It is not a large...
The Possible Hematological Cost of Metabolic Success: Do Incretin-Based Therapies Silently Trigger Anemia?
This review looks at diabetes drugs and anemia. It found that some people on these drugs may get low red blood cell counts. The review cites observational data that show this link....
Rare Hereditary Cardiac Amyloidosis Treated With SGLT2 Inhibitor: Beyond ATTR/AL.
This report describes one man with a rare heart condition called cardiac amyloidosis. He also had kidney disease. Doctors treated him with an SGLT2 inhibitor, a drug often used for...
Association of immune-inflammatory markers with chronic kidney disease in older adults with obesity: a large-scale cross-sectional study.
This study looked at blood tests in older adults in China. It found a link between high levels of certain immune cells and kidney disease in people with obesity. This shows a...
Heat stress-induced gut dysbiosis and multi-organ injury: mechanisms and therapeutic modulation.
This review looks at how extreme heat affects the body. It uses data from rodent models to show that heat can change gut bacteria. This was done in animals, not people yet.
Systematic Review of Exercise Interventions and HRQOL in Predialysis CKD.
This review looked at many studies to see if exercise helps people with kidney disease. It found that exercise can improve how people feel about their health. This is a strong...
Joint Expert Consensus on the Sodium Reduction Policy in Taiwan: A Collaborative Declaration by the Taiwan Hypertension Society (THS), Taiwan Society of Cardiology (TSOC), International Life Sciences Institute (ILSI), and Nutrition Society of Taiwan (NST).
This is a set of guidelines from medical experts in Taiwan. It offers advice on how to lower salt intake to protect the heart and kidneys. It is a policy statement, not a study...
Eighty Years After Vague: Advances in Understanding Ectopic Fat and Metabolic Dysfunction
This is a review of how fat stored in the wrong places, like the liver or kidneys, causes disease. It explains that when body fat overflows, it can damage organs. This is...
Clinical correlates of serum creatinine in alcohol dependence syndrome
This study looked at 129 people with alcohol dependence. It found a link between alcohol use and kidney function markers. It shows a connection, but it does not prove that alcohol...
Challenges, Progress and Hope
This video is part of a series for C3G Awareness Day. It features a person with the disease and a doctor. They share their views on the challenges and progress in treatment. There...
The Mediterranean pyramid: 30 years later, still relevant.
This review looks at the Mediterranean diet. It found that this diet helps prevent heart disease and diabetes. The review cites large studies that show these benefits. This is a...
Baicalein attenuates extracellular matrix remodeling via FN1 in diabetic kidney disease: a multi-omics, machine-learning and mesangial-cell rescue study.
This study used computer models and mouse cells to test a compound called baicalein. It looked at how the compound affects scarring in diabetic kidney disease. These results are...
Disturbed mitochondrial energy production in methylmalonic aciduria is cell-type and variant-dependent
This study looked at cells from people with a rare genetic condition called methylmalonic aciduria. It found that the cells' energy factories, called mitochondria, do not work...
Human-Mouse Atlas of Kidney Myeloid Cells in Lupus Nephritis Reveals Conserved Disease-Associated Macrophages - version 2
This is a preprint that maps immune cells in the kidneys of people and mice with lupus. It is not yet peer reviewed. There are no final results to report.
Novel applications of SIRT1 in Chronic Kidney Disease
This is a review of a protein called SIRT1 that may protect kidneys from scarring. It summarizes what is known about this protein in lab studies. It does not report new human trial...
The role of senescence in kidney ageing, injury and fibrosis
This review explains how old, damaged cells can cause kidney scarring. It discusses how we might target these cells in the future. It is a summary of existing science, not a new...
Estimation of Urinary Marinobufagenin in Stable Chronic Kidney Disease Patients: A Hospital-based Cross-sectional Study.
This study measured a chemical in the urine of people with kidney disease. It checked if this chemical could be a marker for kidney function. The study found a link between the...
Calcineurin Inhibitors and Male Fertility in Renal Transplant Recipients: A Comprehensive Review of Molecular Pathomechanisms and Reproductive Toxicity of Cyclosporine A and Tacrolimus
This review looks at how common transplant drugs affect male fertility. It summarizes what is known about these drugs and the testicles. It does not report new trial results. It is...
Kidney transplantation in patients over 80 years of age: clinical opportunity, ethical controversy, and the need for better selection
This article discusses the challenges of giving kidney transplants to people over 80. It notes that dialysis can reduce independence and quality of life. The authors argue that...
Concomitant Renal and Urinary Bladder Allograft Transplantation
This trial is testing a new way to transplant a kidney and a bladder at the same time. It wants to see if this is possible. There are no results yet because the study is just...
From Remote Monitoring to Actionable Care: Real-World Implementation of an Interoperable Digital Ecosystem for Peritoneal Dialysis
This study looked at using digital tools to help manage peritoneal dialysis at home. It tested a system that shares patient data with doctors. It is about how care is delivered,...
Living with Peritoneal Dialysis: A Phenomenological Exploration of Patients’ Experiences in Caraga Regional Hospital
This study interviewed eight adults doing peritoneal dialysis at home. It explored how the treatment changes their daily life, feelings, and finances. It is a look at patient...
A novel age-norm–capped baseline serum creatinine approach for acute kidney injury diagnosis in critically Ill children: a retrospective cohort study
This study looked at how to best diagnose sudden kidney injury in sick children. It compared two ways to set a baseline blood test level. This shows a link between the method and...
The eye, ear and the kidney: a diagnostic triad in a child with progressive sensory deficits
This report describes one child with hearing loss, vision problems, and kidney issues. It suggests these three problems can happen together. It is a single case report, not a large...
TARGET-EU: Dapagliflozin and major adverse cardiovascular events in type 2 diabetes
This entry shares the code list used in a case study. It is part of a larger project to use real-world data for drug rules. There are no new results in this specific file.
A Rare Presentation of Isoniazid-Induced Cerebellitis in a Patient with Chronic Kidney Disease-Unraveling the Clinical Complexity
This is a case report about one person who developed brain inflammation from a tuberculosis drug. The person also had kidney disease. It is a single patient story, not a large...
STRUCTURAL RETINAL CHANGES IN MALIGNANT RENAL HYPERTENSION WITH THROMBOTIC MICROANGIOPATHY
This is a case report about eye changes in a person with severe high blood pressure and kidney disease. It is a single patient story, not a large study. There are no new trial...
Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis - version 2
This is a preprint about using blood tests to predict kidney damage in lupus. It is not yet peer reviewed. There are no final results to report.
Chronic Kidney Disease‐Associated Pruritus Is Linked to Selective Enrichment of Taurine‐Conjugated Bile Acid Subspecies
People on dialysis who had severe itching had higher levels of certain body chemicals called bile acids. This study shows a link between these chemicals and itching, but it does...
Fumarate Hydratase-Deficient Renal Cell Carcinoma in a Solitary Kidney: Diagnostic Pitfalls and Onco-Nephrology Constraints in an Older Adult With Chronic Kidney Disease
This is a case report about one person with a rare kidney cancer. It describes the challenges of treating this cancer in an older adult with only one kidney. There are no new trial...
Finding Support
This video marks C3G Awareness Day on September 25th. It features a person with C3G and a doctor sharing their views. C3G is a rare kidney disease that can be hard to live with....
Kidney Doctors and C3G
This video marks C3G Awareness Day on September 25th. It features a person with the disease and a doctor sharing their views. There are no new study results in this video.
Person Living With C3G
This video features a person living with C3G, a rare kidney disease. It also includes a healthcare professional sharing their views. The content focuses on awareness and resilience...
Why Heart and Kidney Health Belong in the Same Conversation
This article discusses the link between heart and kidney health. It notes that these conditions are often treated separately. The author argues they should be discussed together to...
Patient-provider partnership and advance care planning readiness among non-dialysis patients with chronic kidney disease.
This study looked at people with kidney disease who are not on dialysis. It checked if they were ready to plan for their future care. The study found a link between patient...
Treatment burden, healthcare experiences, and health-related quality of life among youth with chronic kidney disease treated for hypertension.
This study looked at young people with kidney disease and high blood pressure. It checked how their treatment affected their quality of life. The study found a link between...